Histologic and functional evaluation of lungs reconditioned by ex vivo lung perfusion

Medeiros, Israel Lopes de; Pêgo-Fernandes, Paulo Manuel; Mariani, Alessandro Wasum; Fernandes, Flávio Guimarães; Unterpertinger, Fernando do Vale; Canzian, Mauro; Jatene, Fábio Biscegli

doi:10.1016/j.healun.2011.10.005

Cited by 33 publications

(37 citation statements)

References 16 publications

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“…Indeed, other investigators have continued to report PeO 2 as an equivalent gold standard or primary measure of EVLP lung function. 9 Our data indicate that EVLP is best performed using PeO 2 in association with pulmonary mechanical measures. 5 It is hoped that, in the future, this evaluation will be even further refined with the addition of specific biomarker assays.…”

mentioning

confidence: 65%

Physiologic assessment of the ex vivo donor lung for transplantation

Yeung

Cypel

Machuca

et al. 2012

The Journal of Heart and Lung Transplantation

113

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mentioning

confidence: 65%

Physiologic assessment of the ex vivo donor lung for transplantation

Yeung

Cypel

Machuca

et al. 2012

The Journal of Heart and Lung Transplantation

113

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“…81 Otani et al 82 recently evaluated the effects of EVLP on graft performance in a swine model of DCD. The authors compared grafts after 2 hours of cold ischemia or 2 hours of EVLP.…”

Section: Current Applications Of the Evlp System In Animal And Human mentioning

confidence: 99%

State of Art: Clinical ex vivo lung perfusion: Rationale, current status, and future directions

Sánchez¹,

Bittle²,

Burdorf³

et al. 2012

The Journal of Heart and Lung Transplantation

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“…Medeiros et al (18), when investigating the histologic changes during EVLP, reported no deterioration in lung tissue structure after 1 hr of EVLP and a decrease in the number of apoptotic cells.…”

Section: Assessing the Potential Of Evlp Lungs For Transplantmentioning

confidence: 97%

“…Initially, Steen et al (9) as well as others (15,16) popularized cellular perfusion for EVLP. An acellular perfusate reduces the incidence of red cell lysis and may avoid mechanical lung injury over extended periods of lung perfusion (17,18).…”

Section: Perfusate and Preservative Compositionmentioning

confidence: 99%

Ex Vivo Lung Perfusion

Roman

Nair²,

Tsui³

et al. 2013

Transplantation

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There is a critical mismatch between the number of donor lungs available and the demand for lungs for transplantation. This has created unacceptably high waiting-list mortality for lung transplant recipients. Currently (2012) in the United Kingdom, there are 216 patients on the lung transplant waiting list and 17 on heart and lung transplant list. The waiting times for suitable lungs average 412 days, with an increasing mortality and morbidity among the patients on the lung transplant list. Ex vivo lung perfusion (EVLP) has emerged as a technique for the assessment, resuscitation, and potential repair of suboptimal donor lungs. This is a rapidly developing field with significant clinical implications. In this review article, we critically appraise the background developments that have led to our current clinical practice. In particular, we focus on the human and animal experience, the different perfusion-ventilation strategies, and the impact of different perfusates and leukocyte filters. Finally, we examine EVLP as a potential research tool. This will provide insight into EVLP and its future development in the field of clinical lung transplantation.

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Histologic and functional evaluation of lungs reconditioned by ex vivo lung perfusion

Cited by 33 publications

References 16 publications

Physiologic assessment of the ex vivo donor lung for transplantation

Physiologic assessment of the ex vivo donor lung for transplantation

State of Art: Clinical ex vivo lung perfusion: Rationale, current status, and future directions

Ex Vivo Lung Perfusion

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