Histoire du psoriasis

Halioua, Bruno

doi:10.1016/j.annder.2018.11.001

Cited by 1 publication

(1 citation statement)

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“…Although the first descriptions of psoriasis, a chronic inflammatory disease [1] probably date back to ancient Mesopotamia, the pathogenesis of the disease has not yet been fully elucidated [2]. In more than 80% of cases, psoriasis manifests itself as plaquetype psoriasis appearing a erythematous plaques covered with silvery scales [3].…”

Section: Introductionmentioning

confidence: 99%

Psoriasis and Gut Microbiome—Current State of Art

Polak

Bergler‐Czop

Szczepanek

et al. 2021

IJMS

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Psoriasis is a chronic, immune-mediated inflammatory disease that affects around 125 million people worldwide. Several studies concerning the gut microbiota composition and its role in disease pathogenesis recently demonstrated significant alterations among psoriatic patients. Certain parameters such as Firmicutes/Bacteroidetes ratio or Psoriasis Microbiome Index were developed in order to distinguish between psoriatic and healthy individuals. The “leaky gut syndrome” and bacterial translocation is considered by some authors as a triggering factor for the onset of the disease, as it promotes chronic systemic inflammation. The alterations were also found to resemble those in inflammatory bowel diseases, obesity and certain cardiovascular diseases. Microbiota dysbiosis, depletion in SCFAs production, increased amount of produced TMAO, dysregulation of the pathways affecting the balance between lymphocytes populations seem to be the most significant findings concerning gut physiology in psoriatic patients. The gut microbiota may serve as a potential response-to-treatment biomarker in certain cases of biological treatment. Oral probiotics administration as well as fecal microbial transplantation were most reported in bringing health benefits to psoriatic patients. However, the issue of psoriatic bacterial gut composition, its role and healing potential needs further investigation. Here we reviewed the literature on the current state of the relationship between psoriasis and gut microbiome.

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Section: Introductionmentioning

confidence: 99%