Histogram analysis of apparent diffusion coefficient and fluid-attenuated inversion recovery in discriminating between enhancing and nonenhancing lesions in multiple sclerosis

Wang, Kevin Yuqi; Carlton, Joshua; Guffey, Danielle; Hutton, George J.; Morón, Fanny

doi:10.1016/j.clinimag.2019.08.005

Cited by 3 publications

(1 citation statement)

References 25 publications

(76 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increases in MD/ADC have been reported up to 6 weeks before contrast enhancement, 117 , 118 and MD in enhancing lesions has been shown to be much lower than in non-enhancing lesions. 119 Increased MD in acute multiple sclerosis lesions also appeared to predict risk of developing persistent black holes. 120 Furthermore, DTI measures along white matter tracts showed a progressive increase in MD in patients with no evidence of clinical or radiological disease-activity, 121 and a decrease in RD as well as an increase in AD in progressive patients with multiple sclerosis.…”

Section: Quantitative Mri Techniquesmentioning

confidence: 98%

Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis

Granziera

Wuerfel

Barkhof

et al. 2021

Brain

104

View full text Add to dashboard Cite

Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS, which can be compared across CNS regions, patients, and centres. In patients with multiple sclerosis, quantitative MRI techniques such as relaxometry, myelin imaging, magnetization transfer, diffusion MRI, quantitative susceptibility mapping, and perfusion MRI, complement conventional MRI techniques by providing insight into disease mechanisms. These include: (i) presence and extent of diffuse damage in CNS tissue outside lesions (normal-appearing tissue); (ii) heterogeneity of damage and repair in focal lesions; and (iii) specific damage to CNS tissue components. This review summarizes recent technical advances in quantitative MRI, existing pathological validation of quantitative MRI techniques, and emerging applications of quantitative MRI to patients with multiple sclerosis in both research and clinical settings. The current level of clinical maturity of each quantitative MRI technique, especially regarding its integration into clinical routine, is discussed. We aim to provide a better understanding of how quantitative MRI may help clinical practice by improving stratification of patients with multiple sclerosis, and assessment of disease progression, and evaluation of treatment response.

show abstract