Histocompatible Healing of Periodontal Defects After Application of an Injectable Calcium Phosphate Bone Cement. A Preliminary Study in Dogs

Shirakata, Yoshinori; Oda, Shigeru; Kinoshita, Atsuhiro; Kikuchi, Shigenari; Tsuchioka, Hiroaki; Ishikawa, Isao

doi:10.1902/jop.2002.73.9.1043

Cited by 54 publications

(53 citation statements)

References 38 publications

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“…A rheological test would solve these problems. Investigation of rheological properties could directly depict the hydration process in situ before setting of the cement, and investigate the flow characteristics and the injectable properties of CPC slurry, which is important to the use of CPC as a root canal sealer-filler [12] or as injectable biomaterials [13][14][15][16][17] for bone replacement, especially in percutaneous vertebroplasty [18][19][20] or kyphoplasty [21][22][23]. The references obtained showed that most of them focused on the improvement of injectability of the CPC paste by reducing the viscosity of the system by various methods [29][30][31], just Baroud [33] investigated the steady rheological properties of concentrated b-TCP suspension, which was non-setting system, while CPC is composed of different reactive calcium phosphates, it is a reactive concentrated suspension.…”

Section: Discussionmentioning

confidence: 99%

“…The combination of high biocompatibility, easy-to-shape characteristic, and the capacity to self-setting under ambient conditions makes it an asset in the repair of hard tissue defects [2][3][4][5], and research and development on CPC have attracted much attention in recent years [5][6][7][8][9][10][11]. Based on its flow behavior before setting of slurry, CPC has been used as a root sealer-filler [12] and as an injectable biomaterial [13][14][15][16][17] for bone replacement, especially in percutaneous vertebroplasty [18][19][20] and kyphoplasty [21][22][23], which is a microtrauma surgery to treat osteoporotic vertebrae. The flow characteristics and injectability of CPC are quite important because it requires that the slurry be injectable with low resistance, no powder-liquid phase separation during the injection process, which mainly depends on a suitable rheological property of CPC slurry.…”

Section: Introductionmentioning

confidence: 99%

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Rheological properties of concentrated aqueous injectable calcium phosphate cement slurry

et al. 2006

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rheological properties of concentrated aqueous injectable calcium phosphate cement slurry

et al. 2006

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“…In another study, a self-setting formulation was placed on artificially created periodontal defects but no significant difference was found between the hardened formulation and control. However, the formulation acted as a scaffold for bone formation and provided histocompatible healing of periodontal tissues [553]. Still other investigators used a self-setting formulation for direct pulp capping [554,555] and compared it to calcium hydroxide.…”

Section: Biomedical and Clinical Applicationsmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations

Dorozhkin¹

2013

JFB

151

107

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In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are bioactive and biodegradable grafting bioceramics in the form of a powder and a liquid. After mixing, both phases form pastes, which set and harden forming either a non-stoichiometric calcium deficient hydroxyapatite or brushite. Since both of them are remarkably biocompartible, bioresorbable and osteoconductive, self-setting calcium orthophosphate formulations appear to be promising bioceramics for bone grafting. Furthermore, such formulations possess excellent molding capabilities, easy manipulation and nearly perfect adaptation to the complex shapes of bone defects, followed by gradual bioresorption and new bone formation. In addition, reinforced formulations have been introduced, which might be described as calcium orthophosphate concretes. The discovery of self-setting properties opened up a new era in the medical application of calcium orthophosphates and many commercial trademarks have been introduced as a result. Currently such formulations are widely used as synthetic bone grafts, with several advantages, such as pourability and injectability. Moreover, their low-temperature setting reactions and intrinsic porosity allow loading by drugs, biomolecules and even cells for tissue engineering purposes. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent bioceramics suitable for both dental and bone grafting applications, has been provided.

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“…In another study, a cement was placed on artificially created periodontal defects but no significant difference was found between the cement and control. However, the cement acted as a scaffold for bone formation and provided histocompatible healing of periodontal tissues [486]. Still other investigators used a cement for direct pulp capping [487,488] and compared it to calcium hydroxide.…”

Section: Dental Applicationsmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

Dorozhkin¹

2012

IJMC

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In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are a bioactive and biodegradable grafting material in the form of a powder and a liquid. Both phases after mixing form a viscous paste that after being implanted sets and hardens within the body as either a non-stoichiometric calcium deficient hydroxyapatite (CDHA) or brushite, sometimes blended with un-reacted particles and other phases. As both CDHA and brushite are remarkably biocompartible and bioresorbable (therefore, in vivo they can be replaced with a newly forming bone), self-setting calcium orthophosphate cements represent a good correction technique of non-weight-bearing bone fractures or defects and appear to be very promising materials for bone grafting applications. Besides, these cements possess an excellent osteoconductivity, molding capabilities, and easy manipulation. Nearly perfect adaptation to the tissue surfaces in bone defects and a gradual bioresorption followed by new bone formation are additional distinctive advantages of calcium orthophosphate cements. Besides, reinforced formulations are available; those are described as calcium orthophosphate concretes. Furthermore, formulations with high viscosity, such as pastes and putties are also known. The discovery of self-setting formulations has opened up a new era in the medical application of calcium orthophosphates; several commercial compositions have already been introduced as a result. Many more formulations are in experimental stages. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent biomaterials suitable for both dental and bone grafting applications, has been provided.

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Histocompatible Healing of Periodontal Defects After Application of an Injectable Calcium Phosphate Bone Cement. A Preliminary Study in Dogs

Cited by 54 publications

References 38 publications

Rheological properties of concentrated aqueous injectable calcium phosphate cement slurry

Rheological properties of concentrated aqueous injectable calcium phosphate cement slurry

Self-Setting Calcium Orthophosphate Formulations

Self-Setting Calcium Orthophosphate Formulations: Cements, Concretes, Pastes and Putties

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