Histocompatibility Matching in Penetrating Keratoplasty

Böhringer, Daniel; Sundmacher, Rainer; Reinhard, Thomas

doi:10.1007/3-540-31226-9_8

Cited by 3 publications

(4 citation statements)

References 30 publications

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“…This may also have contributed to the induction of immune reactions. 29 Our observation hints toward the anterior stroma as a major source of immunogenicity because the mushroom graft is composed of more epithelium and subepithelial stroma than the top-hat graft.…”

Section: Discussionmentioning

confidence: 84%

Comparison of Long-Term Outcomes of Femtosecond Laser-Assisted Keratoplasty with Conventional Keratoplasty

Daniel

Böhringer

Maier³

et al. 2016

Cornea

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Section: Discussionmentioning

confidence: 84%

Comparison of Long-Term Outcomes of Femtosecond Laser-Assisted Keratoplasty with Conventional Keratoplasty

Daniel

Böhringer

Maier³

et al. 2016

Cornea

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“…Neben zahlreichen anderen Risikofaktoren (siehe Einleitung) stellt auch die Fadenentfernung einen Risikofaktor für Abstoßungsreaktionen nach pKP dar [7,19]. [27].…”

Section: Abstoßungsrisiko Der Fadenentfernung Nach Pkpunclassified

“…B. phake Patienten (um eine Kataraktentstehung nicht zu provozieren) oder eine Steroidresponse (erhöhter Augendruck unter Steroidtherapie). ▪ Diskussion Die immunologische Abstoßung gefährdet das Transplantatüberleben nach pKP maßgeblich.Abstoßungsrisiko der Fadenentfernung nach pKPNeben zahlreichen anderen Risikofaktoren (siehe Einleitung) stellt auch die Fadenentfernung einen Risikofaktor für Abstoßungsreaktionen nach pKP dar[7,19]. Allerdings gibt es bisher keine veröffentlichte Evidenz für eine wirksame Prophylaxe zur Vermeidung einer Abstoßungsreaktion nach Fadenentfernung.…”

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Survey of Rejection Prophylaxis Following Suture Removal in Penetrating Keratoplasty in Germany

Heinzelmann

Böhringer

Maier

et al. 2021

Klin Monbl Augenheilkd

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Background Penetrating keratoplasty (PK) gets more and more reserved to cases of increasing complexity. In such cases, ocular comorbidities may limit graft survival following PK. A major cause for graft failure is endothelial graft rejection. Suture removal is a known risk factor for graft rejection. Nevertheless, there is no evidence-based regimen for rejection prophylaxis following suture removal. Therefore, a survey of rejection prophylaxis was conducted at 7 German keratoplasty centres. Objective The aim of the study was documentation of the variability of medicinal aftercare following suture removal in Germany. Methods Seven German keratoplasty centres with the highest numbers for PK were selected. The centres were sent a survey consisting of half-open questions. The centres performed a mean of 140 PK in 2018. The return rate was 100%. The findings were tabulated. Results All centres perform a double-running cross-stitch suture for standard PK, as well as a treatment for rejection prophylaxis with topical steroids after suture removal. There are differences in intensity (1 – 5 times daily) and tapering (2 – 20 weeks) of the topical steroids following suture removal. Two centres additionally use systemic steroids for a few days. Discussion Rejection prophylaxis following PK is currently poorly standardised and not evidence-based. All included centres perform medical aftercare following suture removal. It is assumed that different treatment strategies show different cost-benefit ratios. In the face of the diversity, a systematic analysis is required to develop an optimised regimen for all patients.

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“…However, appropriate timing of suture removal after keratoplasty is controversial. 2, 3 We have patients who have experienced wound gaping years after keratoplasty caused by suture removal. In this study, we retrospectively collected such cases and examined the clinical backgrounds associated with wound dehiscence.…”

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confidence: 99%

Clinical Backgrounds of Postoperative Keratoplasty Patients With Spontaneous Wound Dehiscence or Gaps After Suture Removal

Fujii

Matsumoto²,

Fukui³

et al. 2014

Cornea

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Histocompatibility Matching in Penetrating Keratoplasty

Cited by 3 publications

References 30 publications

Comparison of Long-Term Outcomes of Femtosecond Laser-Assisted Keratoplasty with Conventional Keratoplasty

Comparison of Long-Term Outcomes of Femtosecond Laser-Assisted Keratoplasty with Conventional Keratoplasty

Survey of Rejection Prophylaxis Following Suture Removal in Penetrating Keratoplasty in Germany

Clinical Backgrounds of Postoperative Keratoplasty Patients With Spontaneous Wound Dehiscence or Gaps After Suture Removal

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