Histocompatibility (HL‐A) Antigens and Primary Open‐Angle Glaucoma

Abstract

To assess the association between open‐angle glaucoma and HL‐A antigens, the frequencies of 25 HL‐A antigens were determined in 49 patients with OAG and 22 patients with increased intraocular pressure, due to causes other than OAG, using the microcytotoxicity method. The results were compared to 250 individuals from the general population who were tested in the same laboratory at the same period of time. Using rigid statistical analysis, the incidence of the Bw35 antigen was found to be significantly (≪0.012) higher among OAG patients. In a group of 27 first relatives of OAG patients who were tested at the same time, the frequency of Bw35 antigen was increased compared to the general population. The biological importance of the association between Bw35 and OAG, which may still be a chance deviation, is not yet fully understood. It may indicate that the Bw35 antigen or the HLA loci are among the genetic factors which produce susceptibility to open‐angle glaucoma.

Steroid-induced ocular hypertension/glaucoma: Focus on pharmacogenomics and implications for precision medicine

“…However, Francois proposed that children of glaucoma patients should all be moderate responders if this were correct, but only 29 out of 87 tested exhibited a response (Francois, 1977). Subsequent studies found an association between POAG and the histocompatibility loci HLA-A and HLA-B (Aviner et al, 1976; Bigger et al, 1972; Bigger et al, 1975), and between high response to steroids (> 31 mm Hg) and HLA-B12 (Becker et al, 1977; Becker et al, 1976). However, several other studies could not confirm the POAG findings (Damgaard-Jensen and Kissmeyer-Nielsen, 1978; Mayr and Grabner, 1978; Ritch et al, 1978).…”

Histocompatibility (Hla) Antigens in Capsular Glaucoma and Simplex Glaucoma

“…In simplex glaucoma, Aviner et al (1976) found higher frequency of HLA Bw35. We also found a higher frequency (18% against 9% in the control group) but this difference was not significant, perhaps due to a smaller material.…”

“…Patients with open angle glaucoma are reported to have significantly more HLA-B7 and B12, and it has been suggested that occurrence of these antigens is an indicator of the development of visual field loss (Shin et al 1977). Aviner et al (1976) found that Bw35 was more frequent among patients with open angle glaucoma in a material from New York, 47% against 23% in a control series.…”

Hla Histocompatibility Antigens in Open‐angle Glaucoma

“…They furthermore reported that those types were of prognostic value. Aviner et al (1976) found an increase in HLA-BW35, not in B7, and a decrease of B12 (P < 0.05, corrected P a. m. Grumet et al (1971) (P corr.) non-significant).…”