Histocompatibility Class I and II Antigens in Extensive Kindred With Sneddon’s Syndrome and Related Hypercoagulation Disorders

Lousa, M.; Pardo, A; Arnaiz‐Villena, Antonio; Jiménez‐Escrig, Adriano; Gobernado, J. M.

doi:10.1016/j.humimm.2006.10.015

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…The confirmation of these theories has to await the crystal structures of these proteins, which are not available at this time. In summary, the substantial differences between HLA-A*3001 and HLA-A*3002 underline the value of accurate four-digit typing of the HLA-A*30 family in the context of susceptibility to or protection from disease (31). For instance, HLA-A*30 has been identified as one of the risk factors for the development of cytomegalovirus (CMV) disease after allogeneic hematopoietic stem cell transplantation (25).…”

Section: Discussionmentioning

confidence: 99%

Human Leukocyte Antigens A3001 and A3002 Show Distinct Peptide-Binding Patterns of the Mycobacterium tuberculosis Protein TB10.4: Consequences for Immune Recognition

Axelsson-Robertson

Ahmed

Weichold

et al. 2011

Clin Vaccine Immunol

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High-tuberculosis (TB)-burden countries are located in sub-Saharan Africa. We examined the frequency of human leukocyte antigen (HLA) alleles, followed by recombinant expression of the most frequent HLA-A alleles, i.e., HLA-A*3001 and HLA-A*3002, to study differences in mycobacterial peptide presentation and CD8؉ T-cell recognition. We screened a peptide library (9-mer peptides with an 8-amino-acid overlap) for binding, affinity, and off-rate of the Mycobacterium tuberculosis-associated antigen TB10.4 and identified only three TB10.4 peptides with considerable binding to HLA-A*3001. In contrast, 22 peptides bound to HLA-A*3002. This reflects a marked difference in the binding preference between the two alleles, with A*3002 tolerating a more promiscuous peptide-binding pattern and A*3001 accommodating only a very selective peptide repertoire. Subsequent analysis of the affinity and off-rate of the binding peptides revealed a strong affinity (8 nM to 7 M) and moderate off-rate (20 min to 3 h) for both alleles.

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Section: Discussionmentioning

confidence: 99%

Human Leukocyte Antigens A3001 and A3002 Show Distinct Peptide-Binding Patterns of the Mycobacterium tuberculosis Protein TB10.4: Consequences for Immune Recognition

Axelsson-Robertson

Ahmed

Weichold

et al. 2011

Clin Vaccine Immunol

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Recent Advances in Understanding of the Genetics of Antiphospholipid Syndrome

Goel

Ortel

2017

Antiphospholipid Syndrome

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Cervical Spine

Evans¹

2009

Illustrated Orthopedic Physical Assessment

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Histocompatibility Class I and II Antigens in Extensive Kindred With Sneddon’s Syndrome and Related Hypercoagulation Disorders

Cited by 4 publications

References 14 publications

Human Leukocyte Antigens A3001 and A3002 Show Distinct Peptide-Binding Patterns of the Mycobacterium tuberculosis Protein TB10.4: Consequences for Immune Recognition

Human Leukocyte Antigens A3001 and A3002 Show Distinct Peptide-Binding Patterns of the Mycobacterium tuberculosis Protein TB10.4: Consequences for Immune Recognition

Recent Advances in Understanding of the Genetics of Antiphospholipid Syndrome

Cervical Spine

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Histocompatibility Class I and II Antigens in Extensive Kindred With Sneddon’s Syndrome and Related Hypercoagulation Disorders

Cited by 4 publications

References 14 publications

Human Leukocyte Antigens A*3001 and A*3002 Show Distinct Peptide-Binding Patterns of the Mycobacterium tuberculosis Protein TB10.4: Consequences for Immune Recognition

Human Leukocyte Antigens A*3001 and A*3002 Show Distinct Peptide-Binding Patterns of the Mycobacterium tuberculosis Protein TB10.4: Consequences for Immune Recognition

Recent Advances in Understanding of the Genetics of Antiphospholipid Syndrome

Cervical Spine

Contact Info

Product

Resources

About

Human Leukocyte Antigens A3001 and A3002 Show Distinct Peptide-Binding Patterns of the Mycobacterium tuberculosis Protein TB10.4: Consequences for Immune Recognition

Human Leukocyte Antigens A3001 and A3002 Show Distinct Peptide-Binding Patterns of the Mycobacterium tuberculosis Protein TB10.4: Consequences for Immune Recognition