Histocompatibility antigens HLA‐A, ‐B, ‐DR in Greek patients with Kaposi's sarcoma

Papasteriades, C.; Kaloterakis, A; Filiotou, Anna; Economidou, J.; Nicolis, G.; Trichopoulos, D; Stratigos, J.

doi:10.1111/j.1399-0039.1984.tb02143.x

Cited by 44 publications

(22 citation statements)

References 4 publications

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“…An increased frequency of HLA-DR5 was reported in classical, non-HIV-related KS patients as well [21], Mann et al [22] evaluated HLA-DQ antigen frequencies in KS patients and found HLA-DQ 1 to be consistently higher than controls in both the classical non-HIV population and the HIV-positive KS population. They hypothesized that HLA-DQ 1 or a closely linked gene is the MHC KSassociated gene.…”

Section: Discussionmentioning

confidence: 99%

HIV-1 Disease Association with HLA-DQ Antigens in African Americans and Caucasians

Achord

Lewis²,

Brackin³

et al. 1996

Pathobiology

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Previously, we have shown that CD4 levels in African Americans infected with human immunodeficiency virus-1 (HIV-1) were lower than those in Caucasians. To determine whether or not HLA type is associated with susceptibility to HIV-1 infection, we demonstrated serologically that HLA-DQ6(1) and HLA-DQ7(3) were associated with HIV-1 infection in both African Americans and Caucasians. The present investigation was designed to demonstrate whether or not HLA-DQB1 alleles were associated with HIV-1 infection or protection from infection within these two ethnic groups. Oligonucleotide typing was employed and results were analyzed by χ² with Fisher’s exact test to compare HLA-DQ marker frequencies in the regional control population (98 African Americans, 143 Caucasians) to the disease population (n = 52; 30 African Americans and 22 Caucasians). We found a statistically significant increased risk of HIV infection associated with HLA-DQB 1*0605 in African Americans, and with HLA-DQB 1*0602 in Caucasians. By contrast, HLA-DQB 1*0603 was associated with protection in Caucasians.

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Section: Discussionmentioning

confidence: 99%

HIV-1 Disease Association with HLA-DQ Antigens in African Americans and Caucasians

Achord

Lewis²,

Brackin³

et al. 1996

Pathobiology

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“…Other authors link DR5 with throm bocytopenias in the French population [10] and with LAS in the New York population which is predomi nantly of eastern European and Mediterranean origin [12]. HLA-DR5 has increased frequency in classical Ka posi's sarcoma as well [9]. In the present study, the DRwl2 split of DR5 was associated with HIV infection without Kaposi's sarcoma in the Caucasian population and the African American population.…”

Section: Discussionmentioning

confidence: 48%

“…Papaslerialdes et al [9] re vealed a significant increase in HLA-DR5 in the Greek population with classical Kaposi's sarcoma. Some evi dence may, therefore, exist involving DR5 with the same HLA-linked immunogenetic factoifs) associated with the development of the tumor.…”

Section: Introductionmentioning

confidence: 99%

HLA Disease Association and Protection in HIV Infection among African Americans and Caucasians

Cruse

Brackin²,

Lewis³

et al. 1991

Pathobiology

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In a previous investigation, we demonstrated an increased progression of overt AIDS in the African American population compared to the Caucasian population as reflected by the significantly lower absolute number of CD4+ lymphocytes detected in the African American population in an earlier study. The present study elucidates some of the possible genetic factors which may contribute to disease association or protection against HIV infection. The HLA phenotypes expressed as A, B, C, DR and DQw antigens were revealed by the Amos-modified typing procedure. NIH scoring was utilized to designate positive cells taking up trypan blue. A test of proportion equivalent to the χ² approximation was used to compare the disease population (n = 62; 38 African Americans, 24 Caucasians) to race-matched normal heterosexual local controls (323 African Americans, 412 Caucasians). Significant p values were corrected for the number of HLA antigens tested. HLA markers associated with possible protection from infection for African Americans were Cw4 and DRw6, whereas Caucasians expressed none. Disease association markers present in the African American population were A31, B35, Cw6, Cw7, DR5, DR6, DR11, DRwl2, DQw6 and DQw7, whereas in the Caucasian population A28, Aw66, Bw48, Bw65, Bw70, Cw7, Cw8, DRw10, DRw12, DQw6 and DQw7 were demonstrated. The highest phenotypic frequency for a disease association marker in the study was for HLA-DR5 (62.9%) in the HIV-infected African American population without Kaposi’s sarcoma compared to a frequency of 28.9% for the regional control group (p = 0.0012). We conclude that genetic factors do have a role in HIV infection since only 50–60% of those exposed to the AIDS virus will become infected.

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“…(c) Genetic susceptibility ln 1983, ear1y in the AIDS epidemic, the HLA-DR5 haplotype was reported to be associated with the occurrence of Kaposi's sarcoma in homosexual men from New York City (Pollack et al, 1983a;Prince et aL., 1984), an association a1so reported among cases of endemic Kaposi' s sarcoma (Pollack et al, 1983b;Contu et aL., 1984;Papasteriades et al, 1984). Subsequent studies have fai1ed to confirm such an association in either AIDS-related or endemic Kaposi's sarcoma (Melbye et aL., 1987;Brunson et al, 1990;Mann et al, 1990;loannidis et al, 1995;Strichman-A1mashanu et al, 1995).…”

Section: (Iii) Other Infectious Agentsmentioning

confidence: 99%

Monographs on the Evaluation of Carcinogenic Risks to Humans

1991

Analytica Chimica Acta

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Histocompatibility antigens HLA‐A, ‐B, ‐DR in Greek patients with Kaposi's sarcoma

Cited by 44 publications

References 4 publications

HIV-1 Disease Association with HLA-DQ Antigens in African Americans and Caucasians

HIV-1 Disease Association with HLA-DQ Antigens in African Americans and Caucasians

HLA Disease Association and Protection in HIV Infection among African Americans and Caucasians

Monographs on the Evaluation of Carcinogenic Risks to Humans

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