Histocompatibility antigens, autoantibodies, and immunoglobulins in alcoholic liver disease.

Bailey, R.J.; Krasner, N; Eddleston, A. L. W. F.; Tee, D. E. H.; Doniach, Deborah; Kennedy, L.; Batchelor, J. R.

doi:10.1136/bmj.2.6038.727

Cited by 122 publications

(36 citation statements)

References 10 publications

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“…Attempts have been made to define genetic markers of a predisposition towards alcoholism and/or cirrhosis. In patients with chronic alcoholic liver disease, HLA-B8 was reported to be more prevalent in patients with cirrhosis than in controls or patients with fatty liver or minimal fibrosis (233). A similar association was found in British Caucasian alcoholic patients between HLA-B8 and alcoholic hepatitis with or without cirrhosis.…”

Section: Inhibition Of Hepatic Regenerationmentioning

confidence: 72%

Alcohol and the Liver: 1984 Update

Lieber

1984

Hepatology

145

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Section: Inhibition Of Hepatic Regenerationmentioning

confidence: 72%

Alcohol and the Liver: 1984 Update

Lieber

1984

Hepatology

145

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“…Analysis of the association between HLA antigens and various liver diseases reveals some disagreement between different authors (Mackay and Morris, 1972;Bailey et al, 1976;Galbraith et al, 1976;Scott et al, 1977;Simon et al, 1977;Bell and Nordhagen, 1978). Bailey et al (1976) reported an abnormally high frequencyofHLA-B8 (p = 0-025) in alcoholics with cirrhosis but without correcting P; had they done this correction for the specificities studied, the difference would have not been statistically significant.…”

Section: Discussionmentioning

confidence: 97%

Distribution of HLA histocompatibility antigens, ABO blood groups and Rh antigens in alcoholic liver disease.

Melendez¹,

Vargas-Tank²,

Fuentes³

et al. 1979

Gut

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SUMMARY The distribution of 16 antigens of the HLA-A and 15 antigens of the HLA-B series of HLA system, the blood groups ABO, and Rh antigens were studied in 40 alcoholics with cirrhosis, 18 alcoholics without cirrhosis, and in normal control subjects. The group of alcoholics with cirrhosis showed a significantly high frequency of HLA-B13 (corrected P < 0-01) when compared with normal subjects, while the frequency of HLA-B13 was similar to normal in alcoholics without cirrhosis. On the basis of these findings, its seems that the carriers of HLA-B1 3 are more susceptible to liver damage caused by alcohol. Both groups of alcoholics and the normal controls had a similar distribution of ABO blood groups and Rh antigens.Many alcoholics do not develop hepatic disease no matter how long and how much alcohol they have ingested (Insunza et al., 1969). This seems to indicate a different individual resistance and/or susceptibility to hepatic damage related to diet, genetic background, or other possible factors. An important role has been assigned to the human leucocyte antigens (HLA) system in the susceptibility of the host to certain diseases, so that this system could well be a genetic marker in this respect (NIH, 1975;Sasazuki et al., 1977).On the other hand, an association between the blood groups of the ABO system and different diseases has also been reported (Doll et al., 1960;Kingsbury, 1971).In the present study, we examined the relationship between antigens of the HLA system and blood groups of the ABO system and Rh antigens and the heavy drinker's susceptibility to chronic liver damage. MethodsHLA, blood groups, and Rh antigens were assayed in 58 subjects who were drinking or had been drinking more than the equivalent of 100 g ethanol daily for over 10 years. These 58 subjects were divided

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“…It has been shown that patients with alcoholic fatty liver only show a slight in crease in the prevalence of autoantibodies and hyperimmunoglobulinemia [1,14], sug gesting that it may be the degree of liver dam age and not alcoholism per se that is related to the increased humoral immune response in patients with alcoholic liver cirrhosis.…”

Section: Discussionmentioning

confidence: 99%

Autoantibodies and Immunoglobulins in Patients with Alcoholic Cirrhosis

Gluud¹,

Tage-Jensen²,

Rubinstein³

et al. 1984

Digestion

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In order to evaluate the possible relation between hepatic function and hemodynamics and the increased humoral immune response of cirrhotic patients, titres of antinuclear antibodies (ANA) and smooth muscle antibodies (SMA) and concentrations of immunoglobulin (Ig) G, A and M were determined in 74 consecutive patients with alcoholic liver cirrhosis. Patients showed significantly (p < 0.05) increased prevalences of ANA and SMA and concentrations of Ig G, A and M when compared to controls. No significant correlations were found between titres of ANA or SMA and hepatic scan score, galactose elimination capacity, indo-cyanine green clearance, hepatic blood flow and wedged-to-free hepatic vein pressure. Hepatic scan score correlated directly (p = 0.38, p < 0.05) to IgA concentrations; wedged-to-free hepatic vein pressure correlated directly to IgG concentrations (p = 0.35, p < 0.05) and to IgM concentrations (p = 0.42, p < 0.01). No other significant correlations were found between Ig concentrations and variables of hepatic function or hemodynamics.

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Histocompatibility antigens, autoantibodies, and immunoglobulins in alcoholic liver disease.

Cited by 122 publications

References 10 publications

Alcohol and the Liver: 1984 Update

Alcohol and the Liver: 1984 Update

Distribution of HLA histocompatibility antigens, ABO blood groups and Rh antigens in alcoholic liver disease.

Autoantibodies and Immunoglobulins in Patients with Alcoholic Cirrhosis

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