Histochemistry of Glycoconjugates in Merkel Cell Carcinomas

Sames, K.; Schumacher, Udo; Moll, Roland; Moll, Ingrid; Halata, Zdeněk; Asmus, B.; Damme, Els J. M. Van; Peumans, Willy J.

doi:10.1007/978-3-662-10358-6_28

Cited by 1 publication

(3 citation statements)

References 25 publications

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“…These observations suggest malleability of MC microvilli polarity across vertebrates. If microvilli are involved in MC function as previously proposed (Garant et al, 1980; Takahashi-Iwanaga, 2003; Takahashi-Iwanaga and Abe, 2001; Toyoshima et al, 1998; Yamashita et al, 1993), reconciling microvillar dynamics and polarity with MC function will be an interesting area for future exploration.…”

Section: Discussionmentioning

confidence: 87%

“…The core morphological features of MCs include a small and spherical cell body, a high nuclear-to-cytoplasmic ratio, and the presence of neurosecretory granules (Hartschuh et al, 1986; Whitear, 1989). But perhaps the most striking morphological feature of MCs are the numerous actin-rich microvilli that emanate off the cell surface, giving MCs a “mace-like” morphology (Hartschuh et al, 1986; Lane and Whitear, 1977; Sekerková et al, 2004; Takahashi-Iwanaga, 2003; Takahashi-Iwanaga and Abe, 2001; Toyoshima et al, 1998; Whitear and Lane, 1981).…”

Section: Introductionmentioning

confidence: 99%

“…The precise and reproducible cell shape of MCs has been proposed to impact their sensory function (Garant et al, 1980; Takahashi-Iwanaga, 2003; Takahashi-Iwanaga and Abe, 2001; Toyoshima et al, 1998; Yamashita et al, 1993); however, it is unknown how MCs acquire this stereotyped morphology. Cre-based lineage tracing experiments indicate that MCs derive from basal keratinocyte precursors in both mammalian and zebrafish skin (Brown et al, 2023; Morrison et al, 2009; Van Keymeulen et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Dendriticatoh1a+cells serve as transient intermediates during zebrafish Merkel cell development and regeneration

Craig,

Black,

Goo

et al. 2023

Preprint

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Sensory cells often adopt specific morphologies that aid in the detection of external stimuli. Merkel cells encode gentle touch stimuli in vertebrate skin and adopt a reproducible shape characterized by spiky, actin-rich microvilli that emanate from the cell surface. The mechanism by which Merkel cells acquire this stereotyped morphology from basal keratinocyte progenitors is unknown. Here, we establish that dendritic Merkel cells (dMCs) express atonal homolog 1a (atoh1a), extend dynamic filopodial processes, and arise in transient waves during zebrafish skin development and regeneration. We find that dMCs share molecular similarities with both basal keratinocytes and Merkel cells, yet display mesenchymal-like behaviors, including local cell motility and proliferation within the epidermis. Furthermore, dMCs can directly adopt the mature, microvilliated Merkel cell morphology through substantial remodeling of the actin cytoskeleton. Loss of Ectodysplasin A signaling alters the morphology of dMCs and Merkel cells within specific skin regions. Our results show that dMCs represent an intermediate state in the Merkel cell maturation program and identify Ectodysplasin A signaling as a key regulator of Merkel cell morphology.

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