Histochemische und cytochemische Untersuchungen bei der allergischen DNCB-Kontaktdermatitis des Meerschweinchens

Braun‐Falco, Otto; Burg, Günter

doi:10.1007/bf00520345

Cited by 15 publications

(3 citation statements)

References 28 publications

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“…Eosinophil leukocytes occur to a very small extent in allergic DNCB reactions in guinea pigs [2], A rnasson and W aksman [1], on the other hand, found eosinophils in large numbers in so-called retest reactions. If tuberculin, for example, 5-8 days after injection into tuberculin-sensitive guinea pigs, is reinjected at the same site, an accelerated reaction is obtained that is characterized histologically by massive accumulation of eosinophils and a considerable influx of small mononuclear cells in the dermis.…”

Section: Expcri-dncbso3 Sensitized Animalsmentioning

confidence: 99%

Generalized Dermatitis with Epidermal Eosinophilia Induced in Dinitrochlorobenzene-Sensitized Guinea Pigs

Skog¹,

Wahlberg²

1971

Dermatology

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DNCB- and DNCBSO₃-sensitized guinea pigs were injected i.v. with DNCBSO₃. The following phenomena were recorded: (1) the test reaction to DNCB was inhibited; (2) generalized dermatitis arose, and (3) eosinophilic infiltration occurred spotwise in the epidermis. DNCB- and DNCBSO₃-sensitized guinea pigs were united with normal guinea pigs in arteriovenous anastomosis and the sensitized guinea pig was given DNCBSO₃ i.v. The aforementioned phenomena occurred in the sensitized guinea pig. The normal guinea pig reacted with generalized dermatitis, but only in a few experiments with epidermal eosinophilia. The same results were obtained when the normal guinea pig was injected with DNCBSO₃.

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Section: Expcri-dncbso3 Sensitized Animalsmentioning

confidence: 99%

Generalized Dermatitis with Epidermal Eosinophilia Induced in Dinitrochlorobenzene-Sensitized Guinea Pigs

Skog¹,

Wahlberg²

1971

Dermatology

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“…which cells remain nurnerous throughout the obser vation pe1iod. Turk et al (28) and Braun-Falco et al (5) report in hi�tochemical studies on contact hyper�en�itivity that at the peak of the reaction most of the mononuclear cells are lyrnphocytes.…”

Section: Discussionmentioning

confidence: 99%

Measurement and differentiation of the cellular infiltrate in expermiental allergic contact dermatitis

Groth¹,

Skoog²

1979

Acta Derm Venereol

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We describe a quantitative method for the grading of contact allergic reactions in guinea pigs. These reactions are characterized by marked cellular infiltration, and the method is based on total and differential counting of cells in the upper corium. A varying and objectively gradable increase in mononuclear and basophil polymorphonuclear cells was found. In naked-eye-positive reactions this increase was highly significant 24, 48, and 72 hours after epicutaneous application of dinitrochlorobenzene (DNCB). The degree of cellular infiltration reflects aspects of a cell-mediated immune response other than the visible reaction ordinarily made use of. The method can be used to study how systemically or topically administered drugs affect cellular features in contact allergy.

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“…Light microscopically, a fairly large number of macrophage-like cells was found among the splenic ad herent cells, indicating that in vitro macrophages might protect short-time cultured lymphocytes from the toxic effects of metal allergen. In vivo, in patch test contact dermatitis, an early macrophage reaction has been observed [1,6]. The low frequency of macro phage-like cells, found by light-microscopic study of the thymic adherent cells, might have a protective role against the most toxic metal allergen in this study, i.e.…”

mentioning

confidence: 87%

Inhibition of Lymphoid Cell DNA Synthesis by Metal Allergens at Various Concentrations

Nordlind

1983

Int Arch Allergy Immunol

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Metal allergen concentrations inhibiting lymphoid cell DNA synthesis were tested on short-time cultured nonadherent and nonseparated thymic and splenic cells. With all tested metal allergens, the DNA-synthesis-inhibiting effect was more marked for nonadherent compared to nonseparated splenic cells. In thymocytes, a stronger inhibition of nonadherent cells was seen after addition of mercuric chloride. A protective or modifying role of adherent cells towards inhibiting or toxic effects of metal allergens in vitro is postulated.

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Histochemische und cytochemische Untersuchungen bei der allergischen DNCB-Kontaktdermatitis des Meerschweinchens

Cited by 15 publications

References 28 publications

Generalized Dermatitis with Epidermal Eosinophilia Induced in Dinitrochlorobenzene-Sensitized Guinea Pigs

Generalized Dermatitis with Epidermal Eosinophilia Induced in Dinitrochlorobenzene-Sensitized Guinea Pigs

Measurement and differentiation of the cellular infiltrate in expermiental allergic contact dermatitis

Inhibition of Lymphoid Cell DNA Synthesis by Metal Allergens at Various Concentrations

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