Histochemical Study of Gastric Mucosubstances After Thermal Injury

McAlhany, Joseph C.; Czaja, A. J.; Cathcart, Robert S.; Spicer, Samuel S.; Foley, F. D.; Pruitt, Basil A.

doi:10.1097/00005373-197507000-00009

Cited by 4 publications

(1 citation statement)

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“…O'Neill et al [13] have shown in animal models that gastric mucus content and gastric mucus secretion rates decrease following burn injury. However, McAlhany et al [14], on the basis of histochemical studies of gastric mucosal biopsy specimens obtained from burn patients, found gastric mucus content to be normal even in patients with acute mucosal disease. Howe~)er, a depletion of sulfated mucosubstances in chief cells was a consistent finding.…”

Section: Etiologic Factorsmentioning

confidence: 99%

Stress ulcer disease in the burned patient

Pruitt

Goodwin

1981

World j. surg.

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Stress-induced ulcers of the stomach and duodenum in massively burned patients, otherwise known as Curling's ulcers, result from a defect in the mucosal barrier to secreted acid. The etiology of this defect is related, at least in part, to mucosal ischemia, which is aggravated by hypotension, sepsis, and hypoxia. Early prophylactic administration of antacids and cimetidine, either singly or in combination, has significantly reduced the occurrence of the lifethreatening complications of these lesions. When preventive measures have failed or have not been utilized and massive bleeding or perforation has occurred, these complications of Curling's ulcer appear to be best treated by gastric resection combined with vagotomy.

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Section: Etiologic Factorsmentioning

confidence: 99%