Histochemical Studies on Human Mucous Secreting Glands in the Soft Palate, Uvula and Esophagus

R, Lambert; Pansu, D; Bérard, Annie M.; Vitani, C.; Dechelette, M.A.

doi:10.1159/000197306

Cited by 9 publications

(3 citation statements)

References 11 publications

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“…In contrast, glands found in regions more than 3 cm proximal to the GEJ were located almost exclusively in the submucosa and contained greater proportions of acidic mucin. Similar observations have previously been made in the human esophagus, although the glands of the cricopharyngeal region, which were not examined in this study, were found to share the same characteristics as those described for distal glands (35,36).…”

Section: Discussionsupporting

confidence: 88%

Morphology and Glycoconjugate Content of Opossum Esophageal Epithelium and Glands: Regional Heterogeneity and Effects of Acid-Induced Mucosal Injury and Recovery

et al. 2005

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This study examined the regional heterogeneity and site-specific changes in histology and glycoconjugate content following the induction of esophagitis and after recovery in an established animal model. Esophageal samples were excised from five sites in anesthetized opossums 24 hr after 3 consecutive days of 45-min perfusion with saline or 100 mM HCl or 1 week after acid in recovery animals. Controls exhibited significant regional differences in epithelial thickness, gland volume, glycoconjugate composition, and mast cell numbers. Acid perfusion induced erosive esophagitis and significant epithelial denudation throughout the distal 7 cm, combined with significant site-specific increases in gland lumen volume, decreases in mast cell numbers, and changes in glycoconjugate content. No differences from controls were noted in recovery animals, except for a significant increase in epithelial thickness and change in glycoconjugate content in the distal 2 cm. The results of this study highlight the impact of acid exposure on these structural defenses, but further investigation is required to explore the importance of these acid-induced changes in the pathogenesis of reflux esophagitis.

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Section: Discussionsupporting

confidence: 88%

Morphology and Glycoconjugate Content of Opossum Esophageal Epithelium and Glands: Regional Heterogeneity and Effects of Acid-Induced Mucosal Injury and Recovery

et al. 2005

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“…Mean values with SEM calculated from eight subjects. the presence of more than a single glycoprotein in these mixed secretions: (1) multiple bands, giving a positive reaction for carbohydrates are obtained after electrophoretic separation of mixed saliva [11] or chromatography [4]; (2) differences in composition are observed after separate collection of human parotid saliva [18] or submaxillary saliva [11]: (3) a different histochemical pattern characterizes mucous cells in the parotid, sublingual and submaxil lary salivary glands and in accessory glands of the soft palate and uvula [15,16].…”

Section: Discussionmentioning

confidence: 99%

Influence of a Gastric Tube on Salivary and Pharyngeal Mucous Secretions in Man

R¹,

André²,

Descos³

et al. 1973

Digestion

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The contamination of gastric juice by salivary and pharyngeal mucous secretions is influenced by two factors: the control of swallowing and the quantitative variation in salivary secretions induced by the indwelling gastric tube. In order to study the latter factor, comparisons of salivary output were drawn under three conditions: (1) resting, (2) chewing parafilm, (3) presence of a gastric tube introduced orally. In one group of healthy volunteers, the mixed saliva was collected and measured in a 1-hour sample following the three experimental conditions. The fucose, galactose, hexosamines, sialic acids, uronic acids and sulfate concentrations were estimated in salivary dry solids. A nearly 4-fold increase in volume and dry solids was noticed in the ‘parafilm’ and ‘tube’ samples. In the ‘tube’ sample, carbohydrate constituents were twice as high as in the ‘parafilm’ sample and 5–6 times higher as in the ‘resting’ sample. In a second group of volunteers, the same design was carried out, but the collection was fractionated in six; 10-min samples and determinations were limited to fucose and sulfates. Their output was constant under resting conditions and when chewing parafilm. In the presence of a gastric tube, highest values were obtained in the first two samples which were followed by a sharp decrease. In a third group of volunteers a separate collection of salivary and pharyngeal secretions was attempted. The concentration of carbohydrates per ml secretion was 3–5 times higher in the pharyngeal samples, the highest difference being shown by sulfate and uronic acids. It is concluded that on the course of a gastric secretory test, the indwelling gastric tube induces a considerable increase in the acidic mucosubstances of the pharyngeal and salivary secretion. Thus, usual methods (spitting, aspiration, dental pledgets) used to avoid the swallowing of salivary secretions will not eliminate the major source of contamination of gastric juice.

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“…At the third week, strong, broad distribution of lectin binding was observed; in particular, PNA and sucWGA reached their peaks of reactivity. These additional mucous secretions might be required as a lubricant for both chewing and swallowing solid food and may provide a protective coating for the soft palate [39][40][41], and are thus consistent with forced weaning.…”

Section: Weaning Stagementioning

confidence: 89%

Histochemical Characteristics of Glycoproteins During Rat Palatine Gland Development

Hakami

Kitaura

Honma

et al. 2015

Interface Oral Health Science 2014

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Lectin histochemistry has been used to investigate glycosylation modification and glycoprotein expression that occurs during development and under different physiological and pathological conditions. Several lectin histochemical studies have been performed on the palatine gland of different species, which have described the heterogeneity of complex glycoconjugates present in these structures. However, no study has been conducted with regard to the relationship between glycoproteins and palatine gland development in mammals. Therefore, we conducted a study to test the hypothesis that a considerable modification in the expression of carbohydrates occurs in the palatine gland during developmental differentiation and maturation. Histochemical changes of glycoconjugates were observed during prenatal and postnatal development of the rat palatine gland. Qualitative and quantitative differences for the binding of lectins to palatal epithelium sections were determined. All lectins showed general progressive staining during development that was basally extended from the apical cytoplasm of mucous cells. The distribution of glycoproteins during palatine gland development and the heterogeneous distribution of glycoproteins observed between posterior and anterior sides expand our knowledge of the role of salivary glands in oral function. In 183 this review, we describe and discuss glycohistochemical observations of the developing rat palatine gland.

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Histochemical Studies on Human Mucous Secreting Glands in the Soft Palate, Uvula and Esophagus

Cited by 9 publications

References 11 publications

Morphology and Glycoconjugate Content of Opossum Esophageal Epithelium and Glands: Regional Heterogeneity and Effects of Acid-Induced Mucosal Injury and Recovery

Morphology and Glycoconjugate Content of Opossum Esophageal Epithelium and Glands: Regional Heterogeneity and Effects of Acid-Induced Mucosal Injury and Recovery

Influence of a Gastric Tube on Salivary and Pharyngeal Mucous Secretions in Man

Histochemical Characteristics of Glycoproteins During Rat Palatine Gland Development

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