Histochemical studies of oxidoreductases in rat kidney regenerating after mercuric chloride injury

Probing Latent Biomarker Signatures and in Vivo Pathway Activity in Experimental Disease States via Statistical Total Correlation Spectroscopy (STOCSY) of Biofluids: Application to HgCl2 Toxicity

“…Modulation of the TCA pathway intermediates is a recurring theme in mammals undergoing many types of pathological or physiological stress such as toxicity, physical restraint or food deprivation , and reflects mitochondrial perturbation. Hg 2+ binds to sulfydryl groups and directly inhibits the mitochondrial enzymes succinate and malate dehydrogenase, further supporting Hg 2+ -induced mitochondrial perturbation. Decreased urinary excretion of hippurate concentrations was also shown to be a stable differentiating factor between toxin treated animals and controls.…”