Histochemical features of C-cell thyroid carcinoma

Beskid, M; Dabska, M; Klos, Halina; Majdecki, T

doi:10.1016/s0065-1281(77)80131-1

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…The cells of the nodule were marked by the presence of histo chemical reactions, which are usually considered as characteristic of C cells, namely the metachromatic reaction [13,14], a-glycerophosphate menadione re ductase [3,13] and MAO activities [1,3,7,10,13]. Ultrastructurally, the cells of the nodule were similar to the C cells of a normal thyroid gland [5,6], to that of C cell hyperplasia [2,4], and to that of cells of some form of C cell carcinoma [3,9,12,13]. On the other hand it has been demonstrated that C cells of thyroid gland have the ability to metabolize biogenic amines [3,7,10,13] or their precursors [7,10,13].…”

Section: Discussionmentioning

confidence: 99%

“…Ultrastructurally, the cells of the nodule were similar to the C cells of a normal thyroid gland [5,6], to that of C cell hyperplasia [2,4], and to that of cells of some form of C cell carcinoma [3,9,12,13]. On the other hand it has been demonstrated that C cells of thyroid gland have the ability to metabolize biogenic amines [3,7,10,13] or their precursors [7,10,13]. These facts can be associated with the diarrhea mentioned in this case, and which receded after the excision of the nodule.…”

Section: Discussionmentioning

confidence: 99%

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C Cell Adenoma of the Human Thyroid Gland

Beskid¹

1979

Oncology

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A case of C cell thyroid adenoma in a 47-year-old female patient is described. The nodule showed progression over 34 years. The adenoma cells showed histochemical and ultrastructural properties characteristic for C cells. Histologic examination revealed no atypical features of nodule cells nor infiltration of capsule by neoplastic cells. In the period of 8 years following the excision there was neither recurrence nor metastases.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

C Cell Adenoma of the Human Thyroid Gland

Beskid¹

1979

Oncology

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“…Dąbska has authored numerous seminal publications in other areas, including work on cervical, uterine, thyroid, and lung cancer as well as melanoma [43][44][45][46][47][48][49][50][51][52][53][54][55]. She is one of the architects of the Polish classification and nomenclature system for uterine cancer.…”

Section: Research Focusmentioning

confidence: 99%

On Being a Pathologist: Maria Dąbska - the woman behind the eponym, a pioneer in pathology

Schwartz

Janniger

2011

Human Pathology

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“…Medullary thyroid carcinoma (MTC) is a rare neuroendocrine carcinoma, which originates from the C (parafollicular) cells of the thyroid [1][2][3] and constitutes less than 2%-3% of all thyroid malignancies. 1 Carcinoembryonic antigen (CEA) is another important marker for the follow up of MTC patients.…”

Section: Introductionmentioning

confidence: 99%

Cytologic diagnosis of medullary thyroid carcinoma in the Asia‐Pacific region

Liu

Bychkov

Agarwal

et al. 2020

Diagnostic Cytopathology

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Background The accurate preoperative identification of medullary thyroid carcinoma (MTC) is challenging due to the rarity of tumor and variable cytologic appearance. The Asian experience with diagnosing MTC by fine‐needle aspiration (FNA) was scarcely reported. Methods Cases of MTC with available FNA slides were enrolled from 13 hospitals representing 8 Asia‐Pacific countries. Clinicopathological information, including sample preparation technique, staining method, original cytologic diagnosis and review diagnosis were collected. Results Of a total of 145 MTC cases retrospectively recruited, 99 (68.3%) were initially interpreted as MTC/suspicious for MTC (S‐MTC). The distribution of original FNA diagnostic categories was not associated with the staining method or sample preparation technique. The staining methods used were Papanicolaou, hematoxylin‐eosin and Romanowsky stains. Liquid‐based cytology (LBC) was used only in three countries. After reviewing all cases, the diagnostic rate of MTC/S‐MTC increased to 91.7% (133/145). Cases with initially unrecognized MTC had either marked pleomorphism or cytology mimicking papillary carcinoma or follicular neoplasm. Although LBC provided certain benefits, there was no significant difference in diagnostic accuracy between conventional smear and LBC. Immunocytochemistry was available in 38 cases (26.2%), all of which were correctly recognized as MTC. Conclusion Our report summarizes how MTC is handled in contemporary Asian thyroid FNA practice. Although the detection rate of MTC by cytology alone is less satisfactory, integration with ancillary tests could achieve an excellent performance. The recognition of constitutive cytomorphologic features is needed for each cytopreparatory method, which may result in a lower threshold to initiate further workup for MTC.

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Histochemical features of C-cell thyroid carcinoma

Cited by 5 publications

References 24 publications

C Cell Adenoma of the Human Thyroid Gland

C Cell Adenoma of the Human Thyroid Gland

On Being a Pathologist: Maria Dąbska - the woman behind the eponym, a pioneer in pathology

Cytologic diagnosis of medullary thyroid carcinoma in the Asia‐Pacific region

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