Histochemical Expression of Inducible Nitric Oxide Synthase and Inflammatory Cytokines in Alveolar Macrophages in Patients with ARDS.

Intracellular Ca2+ dependence of nitric oxide mediated enhancement of interleukin‐8 secretion in human endothelial cells

“…Several groups demonstrated the potential of nitric oxide to regulate proinflammatory cytokine expression [20–23]. In particular, IL‐8 expression may well be supported by NO ⋅ overproduction in vivo [6]. This cytokine has also been reported to be inducible by Ca 2+ ionophores like A23187 and ionomycin [13, 14].…”

“…Moreover, the application of anti‐IL‐8 provided significant protection in several animal models of these diseases [4, 5]. Together with IL‐8 an increased production of nitric oxide has also been recognized in the same pathological states [6–8]. The potential of nitric oxide to induce IL‐8 gene transcription has recently been demonstrated [9–12].…”

Effect of Inhaled N G -Nitro-L-Arginine Methyl Ester on Candida-Induced Acute Lung Injury

“…6 The levels of nitrite/nitrate in serum or BAL fluid (BALF) are elevated in patients with ARDS and correlate with disease severity. 7,8 Many experimental studies 9 -12 of ALI have shown the presence of inducible NOS (iNOS) and nitrotyrosine, markers of peroxynitrite tissue damage, in alveolar spaces. Thus, NO generated by iNOS may play a critical role in the pathogenesis of ALI.…”