“…6 The levels of nitrite/nitrate in serum or BAL fluid (BALF) are elevated in patients with ARDS and correlate with disease severity. 7,8 Many experimental studies 9 -12 of ALI have shown the presence of inducible NOS (iNOS) and nitrotyrosine, markers of peroxynitrite tissue damage, in alveolar spaces. Thus, NO generated by iNOS may play a critical role in the pathogenesis of ALI.…”