Histochemical detection of zinc by means of sulfarsazene

In Situ Imaging of Metals in Cells and Tissues

“…81 Toroptsev and Eschenko explored the utility of several quinoline sulfonamide derivatives, structurally related to the 8-hydroxy-quinoline indicators, as fluorescence probes for Zn(II). [82][83][84][85] The bright-green fluorescence was found to colocalize with the dithizone staining in pancreatic beta cells and hippocampal mossy fibers. In the 1980s, Frederickson et al explored the utility of another quinoline derivative, 6-methoxy-8-p-toluene sulfonamide quinoline (TSQ, 8) as a histological indicator for Zn(II).…”

“…Similarly, a 2-methyl derivative of 8-hydroxy-quinoline was also described as a histochemical Zn(II) indicator . Toroptsev and Eschenko explored the utility of several quinoline sulfonamide derivatives, structurally related to the 8-hydroxy-quinoline indicators, as fluorescence probes for Zn(II). − The bright-green fluorescence was found to colocalize with the dithizone staining in pancreatic beta cells and hippocampal mossy fibers. In the 1980s, Frederickson et al explored the utility of another quinoline derivative, 6-methoxy-8- p -toluene sulfonamide quinoline (TSQ, 8 ) as a histological indicator for Zn(II). , A comparison of TSQ with the established neo-Timm method demonstrated that the indicator is well suited as stain for demonstrating histochemically reactive Zn(II) in various tissues.…”

Synthesis, Structures and Photophysical Properties of Tetra- and Hexanuclear Zinc Complexes Supported by Tridentate Schiff Base Ligands

“…This combines two important factors: the high sensitivity of fluorescence spectroscopy and the excellent selectivity for Zn 2+ . A set of molecules, which provide these abilities, were already designed and explored: for example, 8-aminoquinoline-based sensor molecules such as 6-methoxy-(8-p-toluenesulfonamide)quinoline (TSQ), Zinquin (ZQ) and 2-(hydroxmethyl)-4-methyl-6-((quinolinyl-8-imino)methyl)phenol (HMQP) [24][25][26][27][28][29][30]. However, what is often left out from consideration is the influence of different anions that may disturb the mechanism of complexation with zinc and the sensitivity of the method.…”