Histochemical and Ultraviolet Microscopic Studies of Chronic Dermatoses and the Corium Membrane

Hollander, Alfred; Sommers, Sheldon C.; Grimwade, Anne E

doi:10.1038/jid.1954.44

Cited by 27 publications

(3 citation statements)

References 19 publications

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“…Several authors have studied the changes of the PAS-reactive basement membrane in psoriasis.l% 15, 74 As a rule, in psoriasis the PAS-reactive basement membrane is represented as a well-formed, slightly wavy line and displays no apparent deviation from normal skin. Wherever an extensive inflammatory infiltrate is formed, and this infiltrate reaches the dermis, the homogeneity of the PAS-reactive basement membrane disappears.…”

Section: Basement Membranementioning

confidence: 99%

The Histochemistry of Psoriasis

Braun‐Falco

1958

Annals of the New York Academy of Sciences

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In order to gain insight into metabolic functions, it is the task of histochemistry to show the presence of chemical substances in cells and tissues with the use of sensitive methods in histological sections.88 If one considers the histochemical findings in psoriasis in this light, there is no doubt that many of them can be related to biochemical findings that in recent times have led Rothman,'". lz7 Griineberg and S~a k a l l ,~7 and Flesch and EsodaJ5 to newer concepts concerning the keratinization process and the nature of psoriasis.The histological picture of psoriasis is dominated by a marked acanthosis and parakeratosis with the formation of Munro's abscesses in the epidermis while, in the dermis, a n inflammatory process is present, especially in the papillary portions. When discussing the histochemistry of psoriasis, one could use these features as guideposts in an attempt to clarify the nature of the disease. This approach has been followed by Steigleder in his extensiye study of the histochemistry of a~a n t h o s i s~~~ and by B r a~n -F a l c o ,~~ Spier and Caneghem,I4O and Steigle~ler'~9 in their detailed works on parakeratosis. However, for the purpose of the present review, it seems to be more appropriate to divide the material on the basis of the histochemical localization of various chemical compounds within the epidermis and dermis with a brief discussion of their functional significance; our knowledge in this last area is still very scant.The following topics will be reviewed: (1) the histochemistry of the epidermis in psoriasis, including the histochemical localization of inorganic substances; of carbohydrates; of lipids; of proteins, amino acids, sulfhydryl groups, and nucleic acids; and of enzymes; and (2) the histochemistry of the corium in psoriasis, including that of the basement membrane; of the capillaries; and of the ground substance.

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Section: Basement Membranementioning

confidence: 99%

The Histochemistry of Psoriasis

Braun‐Falco

1958

Annals of the New York Academy of Sciences

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“…Reinberg el al. [15] as [7] that there was no detectable increase in the DNA content of the epidermis of psoriatics.…”

Section: Discussionmentioning

confidence: 99%

Studies on the Species, Amount and Base Composition of Nucleic Acids in Psoriatic Scales and Normal Horny Layer

Peter¹,

Brand²,

Peter³

1975

Dermatology

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The amount of RNA as well as DNA is considerably increased in psoriatic scales as compared with normal horny layer; RNA was characterized as a low-molecular tRNA; as concerns the base composition of DNA, no particularities in comparison with other DNA species were found, and the base composition of tRNA revealed that cytosine and guanosine are in excess; pseudouridine could not be detected in psoriatic tRNA.

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“…-Figures 8 and 9 The somewhat increased staining of thioglycolate-treated sections (Fig. 9) rep¬ resents the total sulfur content of the tis¬ sues, i. e., it shows the original SH groups as visualized in Figure 8 and Dermatology Section, Veterans' Administration Hospital (9).…”

mentioning

confidence: 99%

Histochemical Observations on Parakeratosis

Steiner¹

1958

Arch Dermatol

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Histochemical and Ultraviolet Microscopic Studies of Chronic Dermatoses and the Corium Membrane

Cited by 27 publications

References 19 publications

The Histochemistry of Psoriasis

The Histochemistry of Psoriasis

Studies on the Species, Amount and Base Composition of Nucleic Acids in Psoriatic Scales and Normal Horny Layer

Histochemical Observations on Parakeratosis

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