Histochemical and chemical studies on pre- and postnatal development of the different systems of ?short? and ?long? adrenergic neurons in peripheral organs of the rat

Owman, Ch.; Sjöberg, Nils‐Otto; Swedin, Göran

doi:10.1007/bf00330631

Cited by 119 publications

(29 citation statements)

References 27 publications

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“…However, although no quantitative estimation of density was carried out in the present study, no impressions of a substantial difference were gained from the electron microscopy. In addition, adult levels of noradrenaline in the rat vas deferens are reached three to five weeks after birth (Owman et al, 1971). …”

Section: Nerve-stimulation -Train Ofpulsesmentioning

confidence: 99%

Post‐natal development of functional neurotransmission in rat vas deferens

Macdonald

McGrath

1984

British J Pharmacology

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4 During trains of pulses the pre-and postjunctional effects of adrenergic transmission which are found in adult rats were absent in vasa from immature rats. 5Electron microscopic studies showed no qualitative differences in adrenergic innervation in vasa from immature and adult rats. 6 It is concluded that a state of 'pre-innervation supersensitivity' associated with a lack of functional adrenergic transmission exists in the vas deferens of immature rats. The supersensitivity disappears and functional transmission develops during the period in which testosterone secretion increases in the rat. The reason for the lack of functional transmission at a time when the innervation appears to be morphologically mature is not clear but may be due to the noradrenaline release mechanism not being fully operative.

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Section: Nerve-stimulation -Train Ofpulsesmentioning

confidence: 99%

Post‐natal development of functional neurotransmission in rat vas deferens

Macdonald

McGrath

1984

British J Pharmacology

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“…The three major salivary glands of the rat are often used in research including autonomic regulation, the process of neuronal development in those glands, and histochemical studies of neurotransmitters and neuropeptides [1,8,13,37,45]. It is generally understood that the salivary secretion of the parotid gland (PG) which is composed almost entirely of serous acini and the submandibular gland (SMG) which is composed of a mixture of serous and mucous acini [31] are controlled by both the sympathetic and parasympathetic nervous systems, and secretion of the sublingual gland (SLG) which is composed of mainly mucous acini appears to be controlled by the parasympathetic nervous system alone [15,51,54].…”

Section: Introductionmentioning

confidence: 99%

Differences in Morphology and Neuropeptide Immunoreactivity of Superior Cervical Ganglion Neurons that Innervate the Major Salivary Glands in Rats.

Miyauchi

Asamoto

Nojyo

et al. 2001

Acta Histochem. Cytochem

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A neuronal tracer, WGA-HRP, was injected into the rat parotid gland (PG), submandibular gland (SMG), and sublingual gland (SLG) to label the superior cervical ganglion (SCG) neurons, and the number, size of soma, dendritic arborization and immunoreactivities (IR) of vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY) were investigated. The number and size of neurons projecting into SMG were greater than those of neurons projecting into the PG or SLG. The PG and SLG projecting neurons did not show significant differences in their number and size of soma, even the weight of the SLG was much smaller than the other two glands. The total length of dendrites of the SMG projecting neurons was greater than those of the PG or SLG projecting neurons. PG and SLG projecting neurons showed no significant difference in the total length of their dendrites. PG and SLG projecting neurons with NPY-IR were larger in number than SMG projecting neurons. SLG projecting neurons with VIP-IR were greater in number than neurons projecting into the other two glands. Our results indicate the differences in morphology and neuropeptide immunoreactivities among the SCG neurons which may be due to the differences in the neuronal functions and the participation of neurotrophic factors.

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“…Among them, Owman, Sjoberg & Swedin (1971) examined the post-natal development of the innervation of the rat vas deferens. They have shown that the density of the adrenergic innervation of the proximal portion of the vas reached essentially an adult level at 16 d of age, while the distal end was innervated later than the proximal portion, and that the adult level of noradrenaline was reached 3-5 weeks after birth.…”

Section: Introductionmentioning

confidence: 99%

Post‐natal Change and Regional Variation of the Response of the Vas Deferens of New‐born Rats to Autonomic Drugs

1984

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SUMMARYThe vas deferens isolated from rats of different ages (I 1-60 d old) was bisected to provide an epididymal and a prostatic half. The contractile responses of both halves to potassium ions, adrenergic agents (noradrenaline, isoprenaline and tyramine), cholinergic agents (acetylcholine, methacholine and tetramethylammonium), histamine and serotonin were measured. The response to 150 mm potassium, which was regarded as an approximate measure of full contractility of the preparation, increased in parallel with the organ weight. Most of the agonists could induce the full contractility in both halves until 3 4 weeks of age, but thereafter they could produce only smaller responses than the full contractility in either or both halves, resulting in a differentiation of the halves in the response to agonists. A regional variation of the post-natal development of c-adrenergic, muscarinic and nicotinic responses is discussed.

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Histochemical and chemical studies on pre- and postnatal development of the different systems of ?short? and ?long? adrenergic neurons in peripheral organs of the rat

Cited by 119 publications

References 27 publications

Post‐natal development of functional neurotransmission in rat vas deferens

Post‐natal development of functional neurotransmission in rat vas deferens

Differences in Morphology and Neuropeptide Immunoreactivity of Superior Cervical Ganglion Neurons that Innervate the Major Salivary Glands in Rats.

Post‐natal Change and Regional Variation of the Response of the Vas Deferens of New‐born Rats to Autonomic Drugs

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