“…The increased expression and deposition of collagens (type I, type III and type IV) were detected in various organ fibroses in human diseases [ 40 – 42 ], a pattern that is similar to the organ fibrosis observed in experimental models [ 5 , 15 , 72 , 73 ]. Advanced stages of fibrosis compromise the functionality of the involved tissues and lead to the development of complications related to end-stage organ failure [ 1 , 12 , 29 , 38 , 53 , 61 , 68 , 69 ]. For instance, renal fibrosis can alter the water, electrolyte and mineral ion balance, inducing vascular calcification and skeletal mineralization defects [ 27 , 28 , 30 – 33 , 49 ].…”