Histoacryl-Kleber zur Akutversorgung von Hornhautperforationen bei nekrotisierender herpetischer Keratitis

Halabi, M El; Seitz, Berthold; Quintin, Adrien; Suffo, Shady; Flockerzi, Fidelis; Schlötzer‐Schrehardt, Ursula; Daas, Loay

doi:10.1007/s00347-020-01284-2

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…Traditionally, endoscopic monomeric nbutyl-2-cyanoacrylate (Histoacryl) injection has long been used effectively to prevent bleeding from esophageal varices [13]. Recently, Histoacryl application has been used safely in various fields such as skin closure [14], gastrointestinal varices or ulcer [29], meniscal repair [30], endovascular leakage [31], placental neoplasm [32], and keratitis [33]. Endoscopic treatment of recurrent tracheoesophageal fistula with Histoacryl has also been reported [34].…”

Section: Discussionmentioning

confidence: 99%

Endoscopic Histoacryl injection for esophagojejunostomy leakage after total gastrectomy in patients with gastric cancer

Kim

Shin

Koh

2023

J Minim Invasive Surg

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Purpose: Esophagojejunostomy leakage after total gastrectomy for gastric cancer is one of the most serious and sometimes life-threatening adverse events. The purpose of this study was to evaluate complications after total gastrectomy in patients with gastric cancer during the period when Histoacryl (B. Braun) injection was performed. Therapeutic outcome of endoscopic Histoacryl injection for esophagojejunostomy leakage was also determined. Methods:This was a single-center retrospective study. Between January 2016 and December 2021, clinicopathologic characteristics and surgical outcomes of 205 patients who underwent total gastrectomy were investigated. Baseline characteristics and clinical outcomes of 10 patients with esophagojejunostomy leakage were also investigated. Results:Postoperative complication and mortality rates of total gastrectomy in 205 patients were 25.4% and 0.9%, respectively. Serious complications more than Clavien-Dindo IIIb accounted for 6.3%. Ten (4.9%) esophagojejunostomy leakages occurred in 205 patients. Among 10 esophagojejunostomy leakage patients, endoscopic Histoacryl injection was performed on eight patients and leakage was successfully managed with endoscopic Histoacryl injection in seven patients (87.5%). Mean postinjection hospital stay of seven successfully managed patients was 13.8 days. They were able to drink water at 1-6 days after injection. Among eight patients with endoscopic Histoacryl injection, six patients were injected once and two patients were injected three times. Conclusion:Endoscopic Histoacryl injection for esophagojejunostomy leakage after total gastrectomy can be considered as a useful treatment for some selected cases.

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Section: Discussionmentioning

confidence: 99%

Endoscopic Histoacryl injection for esophagojejunostomy leakage after total gastrectomy in patients with gastric cancer

Kim

Shin

Koh

2023

J Minim Invasive Surg

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“…Triple-PKP à chaud) 19 . Sollte nicht unmittelbar Hornhautgewebe zur Verfügung stehen und die Perforation klein genug sein (in der Regel < 1 mm), kann eine Hornhautklebung mit Histoacryl-Kleber durchgeführt werden, um später eine elektive PKP zu ermöglichen 20 . Vor Applikation des Klebers muss das umgebende Epithel abradiert und die Vorderkammer mit Luft oder hochviskösen kohäsiven Substanzen gefüllt werden.…”

Section: Therapieunclassified

Hornhautulkus – Handlungspfad

Hamon¹,

Daas²,

Seitz³

2022

Augenheilkunde up2date

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Hornhautulzera können die anatomische Integrität der Augenoberfläche oder die Transparenz der Hornhaut schnell gefährden und zu einem tiefen und dauerhaften Verlust des Visus führen. Die ätiologische Diagnose ist vielfältig und nicht immer einfach. Es ist jedoch wichtig, schnell zwischen einer infektiösen, entzündlichen oder trophischen Ursache zu unterscheiden, da sie über das adäquate therapeutische Vorgehen entscheidet.

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“…tumor-excisions and erosion of transscleral tubes. There are several techniques for restoring scleral and corneal integrity, including the use of fibrin glue or cyanoacrylate in small defects [1][2][3], hydrogel-based adhesive patch [4] and amniotic membrane transplantation [5] in slightly larger defects and lamellar keratoplasty [6] and penetrating keratoplasty (PK) [7,8] for large defects. Keratoplasties with the primary goal of restoring the integrity of the globe rather than primarily restoring visual function are referred to as tectonic.…”

Section: Introductionmentioning

confidence: 99%

Indications, techniques, and graft survival of mini and corneo-scleral tectonic keratoplasties: A retrospective single-center case series

et al. 2023

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Purpose Tectonic keratoplasties (TK) are used to treat corneal and scleral perforations and to prevent the loss of the eye. In this study, we retrospectively analyzed indications, surgical procedures, and outcomes of eccentric mini and corneo-scleral tectonic keratoplasties with respect to anatomical survival and clear graft survival rates to identify risk factors for graft failure. Methods This retrospective study includes 33 eccentric mini (graft diameter <6 mm) and/or corneo-scleral TK of 32 consecutive patients of a total of 41 TK carried out between 2005 and 2020 in the Eye Center, University of Freiburg, Germany, making up 0.7% of all keratoplasties performed during this period (n = 5557). Patient and graft specific data were extracted from medical files. Anatomical survival—defined as achieving integrity of the globe without further surgical interventions—and clear graft survival—defined as persisting graft clarity—were estimated using the Kaplan-Meier method. We also fitted Cox proportional hazard models to account for factors influencing anatomical and clear graft survival. Results Median duration of anatomical success was 72.5 months (95% confidence interval (CI) 18.1—infinite (inf.)) and median duration of clear graft survival was 29.6 months (95% CI 12.5-Inf.). The 1-year survival rate for anatomical survival was 67.6% (95% CI 52.2% - 87.6%) and for clear graft survival 66.4% (95% CI 50.5%– 87.1%). No enucleation was necessary during this time-period. Non-inflammatory primary causes (n = 14) presented a trend towards better anatomical survival rates (median remained above 0.75 during follow-up) compared to inflammatory primary causes (n = 19, median 18.1 months (95% CI 2.8 - inf.)) and longer clear graft survival (median 29.6 months (95% CI 12.5 - inf.) versus 13.1 months (95% CI 3.2 - inf.)). Corneo-scleral grafts (n = 18) compared to corneal grafts (n = 15) showed a trend towards better anatomical survival (more than 50% of eyes did not fail during follow-up period (95% CI 21.9-Inf. months) versus 18.1 months (95% CI 2.4-Inf.)) and clear graft survival (median 29.6 months (95% CI 12.6-Inf.) versus 6.2 months (95% CI 2.8-Inf.)). Old age (n = 11, 75.2 – 90.1 years) compared to young age (n = 11, 6.2 – 60.2 years) was the only hazard ratio (hazard ratio 0.04 (95% CI 0.002–0.8)) that reached the level of significance (p = 0.03). Conclusion Eccentric TK is helpful in the successful treatment of a variety of severe eye diseases. Patients at young age, with pre-existing inflammatory conditions or corneal TK are at higher risk for anatomical failure as well as clear graft failure and therefore need to be monitored closely.

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Histoacryl-Kleber zur Akutversorgung von Hornhautperforationen bei nekrotisierender herpetischer Keratitis

Cited by 5 publications

References 23 publications

Endoscopic Histoacryl injection for esophagojejunostomy leakage after total gastrectomy in patients with gastric cancer

Endoscopic Histoacryl injection for esophagojejunostomy leakage after total gastrectomy in patients with gastric cancer

Hornhautulkus – Handlungspfad

Indications, techniques, and graft survival of mini and corneo-scleral tectonic keratoplasties: A retrospective single-center case series

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