Histo‐morphometric analysis applied to spleens of Marek's disease virus inoculated chickens

Maas, H. J. L.; Orthel, F.W.

doi:10.1080/03079457608418185

Cited by 3 publications

(5 citation statements)

References 8 publications

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“…La bourse de Fabricáis, le thymus et la rate présentent une importante régression lymphoïde comme l'avaient montré Jakowski et al (1969Jakowski et al ( , 1970Cauchy, 1971;Maas et Orthel, 1976;Chijo et al, 1981). Cette atteinte est précoce et simultanée et il n'y a pas de restauration complète de l'aspect histologique normal de ces organes 20 semaines après l'infection.…”

Section: Fig 5 Régression Lymphoïde Des Follicules De La Bourse De unclassified

“…Cependant il n'a pas toujours été possible de déterminer l'évolution de certaines lésions. En effet l'utilisation de 4 variables qualitatives à la place de variables quantitatives continues comme en histomorphométrie diminue considérablement la puissance des tests statistiques portant sur les observations (Maas et Orthel, 1976).…”

Section: Fig 5 Régression Lymphoïde Des Follicules De La Bourse De unclassified

“…Eli entraîne principalement des modifications histologiques des nerfs (Wight, 1962(Wight, , 1969Payne et Biggs, 1967;Payne et al, 1976;Fujimoto et aï., 1971) et des organes lymphoïdes (Jakowski et al, 1969;Payne et Rennie, 1973;Payne et al, 1976). Seules quelques études traitent de l'évolution des lésions histologiques de la maladie expérimentale (Payne et Biggs, 1967;Cauchy, 1971;Maas et Orthel, 1976;Ichijo et aï., 1981). Leur durée d'observation est souvent courte ne dépassant pas 12 semaines.…”

Section: Introductionunclassified

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Etude statistique de l'evolution des lesions histologiques au cours de l'infection experimentale du poulet par le virus de la maladie de marek

Bourhy

Wyers

Guittet³

et al. 1988

Avian Pathology

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Section: Fig 5 Régression Lymphoïde Des Follicules De La Bourse De unclassified

Section: Introductionunclassified

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Etude statistique de l'evolution des lesions histologiques au cours de l'infection experimentale du poulet par le virus de la maladie de marek

Bourhy

Wyers

Guittet³

et al. 1988

Avian Pathology

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“…White Leghorn strain A (WL-A) was used (Maas and Orthel, 1976). Virus strains and control preparation (1) JM (Sevoian et al, 1962) was kindly supplied by Dr. B.R.…”

Section: Chickensmentioning

confidence: 99%

Quantitative pathogenicity of Marek's disease virus and vaccine virus strains in chickens: Macroscopical aspects

Maas¹,

Orthel²,

Rispens³

et al. 1978

Avian Pathology

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SUMMARYTwo virulent strains (JM and K) and one vaccine strain (CVI 988) of Marek's disease virus (MDV), together with two vaccine strains of the herpesvirus of turkeys (HVT) (FC 126 and PB-THV 1), all in the cellassociated state, were administered intramuscularly at 3.7 log TCID 50 per dose to day-old SPF White Leghorn chickens. A control group of chicks received uninfected cells.The pathological parameters studied were onset and duration of clinical symptoms, mortality, bird weight and macroscopical lesions of peripheral nerves and visceral organs. Data were obtained from females autopsied at the age of 3, 8 and 20 weeks, and from chickens which died. Virological and serological data were procured mainly from males taken at various ages.The results indicate a clear distinction between virulent and vaccine strains. MD vaccines had no significant influence on bird weight and caused no mortality or macroscopical lesions, whereas the virulent MDV strains produced all these effects. Macroscopical lesions caused by the virulent MDV strains were seen predominantly in nerves (in about 50% of birds succumbing to MD) and gonads (in 0% to 80% of such birds depending on sex and on strain of MDV). Differences between the two virulent strains could be demonstrated. Strain JM induced earlier incidence and shorter duration of clinical disease. With strain JM death occurred earlier in females than in males. Strain K caused significantly more macroscopical lesions in gonads, heart and liver.

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“…Chickens in experiments Nos.l and 3 were SPF White Leghorns (WL) strain A as described previously (Maas and Orthel, 1976). In experiment No.2 commercial WL chickens were employed which had maternal antibodies.…”

Section: Chickensmentioning

confidence: 99%

Absence of Marek's disease virus antigen in the feather follicle epithelium of vaccinated chicks demonstrated by immunofluorescence

Maas

Vloten²,

Vreede‐Groenewegen³

et al. 1978

Avian Pathology

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SUMMARYIn chickens vaccinated with MDV strain CVI 988, HVT strain FC 126 or PB-THV 1, no MDV-specific antigens could be demonstrated in the feather follicle epithelium by immunofluorescence (IF). In chickens given virulent MDV strains, the epithelium of the feather follicle was positive in IF. In an experiment where chickens were vaccinated with strain CVI 988, positive IF was observed in the lung, bursa and pancreas, but not in the feather follicle epithelium, kidney, cloaca, or caecal tonsils. Absence of IF antigen in the skin may be indicative of avirulence of the strain of MDV.

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Histo‐morphometric analysis applied to spleens of Marek's disease virus inoculated chickens

Cited by 3 publications

References 8 publications

Etude statistique de l'evolution des lesions histologiques au cours de l'infection experimentale du poulet par le virus de la maladie de marek

Etude statistique de l'evolution des lesions histologiques au cours de l'infection experimentale du poulet par le virus de la maladie de marek

Quantitative pathogenicity of Marek's disease virus and vaccine virus strains in chickens: Macroscopical aspects

Absence of Marek's disease virus antigen in the feather follicle epithelium of vaccinated chicks demonstrated by immunofluorescence

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