1979
DOI: 10.1267/ahc.12.361
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Histo- And Biochemical Studies on Dehydrogenases in Tumorigenesis in Rat Zymbal Glands Induced With Dmba and Das

Abstract: Wistar SLC male rats were injected with 25 mg/Kg of 7,12-Dimethylbenz(a)anthracene intravenously twice at 51 and 66 days of age, and also fed on a commercial diet containing 4-Dimethylaminostilbene, 0.004%, from the age of 57 days to the respective days of their decapitations.Fresh cryostat serial sections of Zymbal glands were examined by histochemical methods for SDH, LDH and G6PDH 6, 11 and 17 weeks after the first injection.Either atypical hyperplasia of the acinar cells or microtumor was detected in the Z… Show more

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Cited by 3 publications
(2 citation statements)
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“…Biochemical determinations of dehydrogenases in the local tumorigenesis indicated that LDH increased prominently in the malignant tissues. It is useful to relate the concentration of LDH in tissues to MDH when both enzymes are assayed concurrently on the same solution of tissue constituents, with respect to malignant transformation in rats (10,13,14). The quotients were higher on the more malignant tissues of the present experiment, owing to the higher LDH activities.…”
Section: Resultsmentioning
confidence: 99%
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“…Biochemical determinations of dehydrogenases in the local tumorigenesis indicated that LDH increased prominently in the malignant tissues. It is useful to relate the concentration of LDH in tissues to MDH when both enzymes are assayed concurrently on the same solution of tissue constituents, with respect to malignant transformation in rats (10,13,14). The quotients were higher on the more malignant tissues of the present experiment, owing to the higher LDH activities.…”
Section: Resultsmentioning
confidence: 99%
“…Histochemically, atypisms of ALP and LDH activities were observed on the apparent malignant tissues induced by DMBA-dusting. Biochemical observations on the activities of LDH and MDH and on the pattern of LDH isoenzymes were done for the induced nodules with DMBA-dusting over females aged [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26] weeks, which were harvested 5-18 weeks after the local application. The quotients of LDH/MDH in the same sample elevated on the malignant tissues prominently owing to higher LDH activity, and the elevation was moderate on the earlier-harvested, granulomatous tissues.…”
mentioning
confidence: 99%