Histiocytosis X: IV—Immunologic response assessed by lymphocyte transformation tests

Six children with histiocytosis X, all in clinical remission, were investigated for antibody-dependent cytotoxicity mediated by monocytes and neutrophils. Monocytes demonstrated a reduced cytotoxicity and a normal Fc receptor activity. Judged by light microscopy the monocytes were normal. Preincubation with the patient's serum did not influence the cytotoxicity of normal monocytes. Neutrophils from patients with histiocytosis X showed a normal cytotoxic activity. We postulate a functional defect of the mononuclear phagocyte system in histiocytosis X.

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Histiocytosis X: IV—Immunologic response assessed by lymphocyte transformation tests

Cited by 3 publications

References 6 publications

Hypergammaglobulinemia in histiocytosis X

Hypergammaglobulinemia in histiocytosis X

Histiocytosis X: A seven-year experience at a children's hospital

Histiocytosis X–an immune deficiency disease? Studies on antibody-dependent monocyte-mediated cytotoxicity

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