Histiocytosis X. A Report of 15 Cases in the Paediatric Age Group

Induction of stathmin expression during liver regeneration

“…It was suggested that stathmin is involved in a biochemical pathway leading specifically to down-regulation of DNA synthesis in proliferating peripheral lymphocytes [42,43]. Blocking of stathmin mRNA translation using antisense oligonucleotides delayed entrance of mitotitally stimulated lymphocytes into S phase and inhibition of lymphoid proliferation with cyclosporin resulted in decrease of stathmin levels [44]. Our present results show that.…”

Histiocytosis X [Abridged]

“…In 8 of the cases the lesions were present in more than one bone, while a single bone was affected in the other 12 cases. As has been noted in other series (Hodgson et al 1951, Avery et al 1957, Melhem et al 1964, Takahashi et al 1966, flat bones were more commonly involved than long bones, the skull being the most frequently affected bone. It is generally recognized that the femur is the commonest long bone to be affected, but the disease may be manifested in any bone.…”

Histiocytosis ‘X’ of the Central Nervous System

“…On other hand, the temporal sequence of events in this case can not rule out the possibility that diabetes insipidus was due to the radiation treatment [26]. Other manifestations of HSCD (such as recurrent otitis, anemia, abnormalities of body growth, alterations of lymph nodes, skin and subcutaneous tissues, and membranes [17] were absent. The asymptomatic, transitory pulmonary infiltration which was found on the first chest X-ray, disappeared later and left no trace at autopsy, could or could not have been the expression of a pulmonary localization.…”

“…Melhem el al. [17] pointed out that lung involvement in HX in children, even if asymptomatic, occurs with the more severe forms of the disease and is a bad prognostic omen. However, solitary lung involvement (such as in our case, but usually observed in adults) carries a more favorable prognosis regarding life.…”