Histiocytoid giant cellulitis-like Sweet’s syndrome: case report and review of the literature

So, Jessica Kim; Carlos, Casey A.; Frucht, Corey S; Cohen, Philip R.

doi:10.5070/d3213024175

Cited by 12 publications

(6 citation statements)

References 30 publications

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“…Its in ltrate of the dermis consists mainly of mature neutrophils [4]. Sweet syndrome with both histiocytoid pathology and giant cellulitis-like lesion feature is extremely rare and has only been reported once [5]. Here we report a patient with a cutaneous lesion caused by local invasive irritation, which is different from the previous report and much more di cult to distinguish from cellulitis.…”

Section: Introductionmentioning

confidence: 70%

“…The in ltrate of the dermis consists mainly of mature neutrophils, and its relationship with malignancy remains to be clari ed [4,9,10]. Histiocytoid giant cellulitis-like Sweet syndrome is extremely rare, the only reported case was a 72-year-old woman who developed a single lesion on her leg while gradually reducing the dose of prednisone for foot pain, and then diagnosed with unclassi able myelodysplastic/myeloproliferative neoplasm [5]. Based on the clinical characteristics of these two patients, this unique variant seems to have an unifocal lesion and may closely related to myeloid malignancies, especially MDS.…”

Section: Discussion Conclusionmentioning

confidence: 99%

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Histiocytoid Giant Cellulitis-Like Sweet Syndrome At The Site of Sternal Aspiration: A Case Report

Zhao

Sun

2021

Preprint

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Background: Sweet syndrome with both histiocytoid pathology and giant cellulitis-like lesion feature is extremely rare and has only been reported once. Our case is different from the previous report because the cutaneous lesion was caused by local invasive irritation, which made it much more difficult to distinguish from cellulitis.Case presentation: A 52-year-old male was diagnosed with myelodysplastic syndrome with multilineage dysplasia (MDS-MLD) associated with myelofibrosis (MDS-F) as well as angioneurotic edema of the tongue and floor of the mouth. Seven days after sternal aspiration, a cellulitis-like lesion was formed at the puncture site. Since he had neutropenia, history of glucocorticoid use and didn't keep the site dry and clean after aspiration, cellulitis was diagnosed, followed by broad-spectrum antibiotics and debridement. However, the lesion continued to expand, associated with blisters formation, accompanied by chills and fever. Blood cultures and blister smears didn't detect any pathogens. Biopsy of the lesion was performed and histiocytoid Sweet syndrome was diagnosed. He received prednisone treatment, and the fever relieved within 24 hours and the cutaneous lesion resolved within one week. He has had no recurrence during two-month follow-up.Conclusions: This case can provide help for timely diagnosis and treatment and a reference for further summarizing the characteristics of this rare variant.

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Section: Introductionmentioning

confidence: 70%

Section: Discussion Conclusionmentioning

confidence: 99%

Histiocytoid Giant Cellulitis-Like Sweet Syndrome At The Site of Sternal Aspiration: A Case Report

Zhao

Sun

2021

Preprint

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“…Recently, GCS, which is a rare variant of SS has been reported in literature ( Table 1 ) 13 19 20 . In contrast to classic SS, which usually occurs in the head, neck, and upper extremities, GCS mainly involve lower half of the body in obese, middle-aged females.…”

Section: Discussionmentioning

confidence: 99%

“…But in our case, it was distinct that dermal infiltration of mononuclear cells with a histiocytic appearance was also prominent in addition to the typical feature of SS. To date, of the 6 patients with GCS in literature, only 1 case shared the characteristics of histiocytoid SS has been reported 19 . Although still lacking the comprehensive understanding for this variant, on the basis of clinicopathologic findings, our case was quite consistent with those of previous reports of GCS.…”

Section: Discussionmentioning

confidence: 99%

Giant Cellulitis-like Sweet Syndrome Following Varicose Vein Surgery: A Rare Variant of Sweet Syndrome Mimicking Cellulitis

et al. 2023

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Giant cellulitis-like Sweet syndrome (GCS) is the most recently defined variant of Sweet syndrome (SS) which could clinically mimic wide-spreading cellulitis. Although there has been only paucity of reports in the literature, it mostly appears at lower half of the body and histologically shows dense infiltration of neutrophils with occasional histiocytoid mononuclear cells. Although its exact etiology has not been clarified, abnormal conditions (e.g., infection, malignancy and drugs) could be related triggering factors and trauma itself can be one of the causative elements as a ‘pathergy phenomenon’. GCS could be confusing manifestation especially when appeared in postoperative condition. A 69-year-old female presented with an erythematous edematous papules and plaques on the right thigh after varicose vein surgery. Skin biopsy revealed diffuse neutrophilic infiltrates that was consistent with SS. To our knowledge, there has been no report of GCS as a postoperative complication after varicose vein surgery. Physicians should be aware of this uncommon reactive neutrophilic dermatoses mimicking infectious cutaneous disease.

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“…SS with both the pathological characteristics of H-SS and the lesion features of GC-SS is HGC-SS. The only reported case of HGC-SS involved an elderly woman with a MN, who also had a progressively enlarging solitary lesion, which, unlike in the present case, occurred without local irritation, and the lesion was sharply demarcated without bulla formation, making it easier to distinguish from cellulitis[ 21 ]. The clinical features of this particular type of SS require further investigation.…”

Section: Discussionmentioning

confidence: 99%

Histiocytoid giant cellulitis-like Sweet syndrome at the site of sternal aspiration: A case report and review of literature

Zhao¹,

Ni²,

Sun³

2022

WJCC

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BACKGROUND Giant cellulitis-like Sweet syndrome (SS) is a rare subtype of SS, and reports of the combined histiocytoid type of pathology are scarce. Here, we report a case of SS with distinctive clinical presentations and which was difficult to distinguish from cellulitis. By sharing this case and a discussion of the related literature in detail, we aim to provide clinicians with new insights into the characteristics of histiocytoid giant cellulitis-like (HGC)-SS and the pathogenesis of SS. CASE SUMMARY A 52-year-old male was admitted after experiencing progressive fatigue for 1 mo and tongue swelling with pain for 1 d. He was diagnosed with myelodysplastic syndrome (MDS) and angioneurotic edema of the tongue and floor of the mouth. However, 7 d after examination by sternal aspiration, a violaceous, tender, and swollen nodule developed at the site, with poorly demarcated erythema of the surrounding skin. Considering his profile of risk factors, the diagnosis of cellulitis was made and he was administered broad-spectrum antibiotics. When the lesion continued to worsen and he developed chills and fever, pathogenic and dermatopathological examination led to the diagnosis of HGC-SS. Treatment with prednisone led to the fever being relieved within 24 h and the skin lesion being resolved within 1 wk. The patient refused intensive treatment and was instead given thalidomide, erythropoietin, stanozolol, and supportive care. The prednisone was gradually tapered, with no signs of recurrence, but he died 2 mo later of severe pneumonia. CONCLUSION HGC-SS demonstrates unique manifestation. SS and leukemia cutis share cytological origin. Myelofibrosis and SS are adverse prognostic factors for MDS.

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Histiocytoid giant cellulitis-like Sweet’s syndrome: case report and review of the literature

Cited by 12 publications

References 30 publications

Histiocytoid Giant Cellulitis-Like Sweet Syndrome At The Site of Sternal Aspiration: A Case Report

Histiocytoid Giant Cellulitis-Like Sweet Syndrome At The Site of Sternal Aspiration: A Case Report

Giant Cellulitis-like Sweet Syndrome Following Varicose Vein Surgery: A Rare Variant of Sweet Syndrome Mimicking Cellulitis

Histiocytoid giant cellulitis-like Sweet syndrome at the site of sternal aspiration: A case report and review of literature

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