Histiocytic typhlocolitis in two colony Beagle dogs

Carvallo, Francisco R.; Kerlin, Roy L.; Fredette, Claudine; Pisharath, Harshan; DebRoy, Chitrita; Kariyawasam, Subhashinie; Pardo, Ingrid

doi:10.1016/j.etp.2014.10.004

Cited by 10 publications

(8 citation statements)

References 9 publications

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“…It has also been reported in the Mastiff , Alaskan malamute, Doberman pinscher, English bulldog (Manchester et al 2013) and Beagle (Carvallo et al 2015). Young dogs are predominantly aff ected with clinical signs which are similar to those observed in other forms of chronic colitis (Sherding 2003).…”

Section: Discussionmentioning

confidence: 71%

Granulomatous colitis in two French bulldogs unresponsive to fluoroquinolone antimicrobials: a case report

Lucena¹,

Novales²,

Ginel³

2017

Vet. Med. - Czech

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Two cases of granulomatous colitis in two French bulldogs were found to be unresponsive to fluoroquinolones. The granulomatous colitis diagnosis was made on the basis of PAS-positive histiocytes in the lamina propria of the colonic mucosa in biopsy samples taken at colonoscopy. Remission of granulomatous colitis has been reported using fluoroquinolones leading to the idea that invasive Escherichia coli strains in the colonic mucosa are involved. Oral enrofloxacin (Baytril 150 mg, Bayer, Spain) at 10 mg/kg per day for eight weeks was prescribed to both dogs in this study. A first course of therapy resolved the problem in dog No. 1, which, however, was followed by relapse three months later without enrofloxacin response. No clinical remission was seen in dog No. 2 and 4.4 mg/kg marbofloxacin (Marbocyl P 20 mg, Vetoquinol, Spain) per day for 10 weeks was administered but without any response. From both dogs, biopsy samples from the colonic mucosa were taken during colonoscopy. Samples were homogenised for microbial culture in different agar media to identify invasive microbes. Escherichia coli were largely isolated and antibiotic sensitivity testing (MIC of E. coli to selected antimicrobials, CLSI 2013) was carried out. In both cases, E. coli was resistant to fluoroquinolones. In dog No. 1 E. coli was susceptible to amoxicillin-clavulanate, cefazolin, amikacin and gentamicin whereas in dog No. 2 it was susceptible to doxycycline and amoxicillin-clavulanate. Clinical remission was achieved in dog No. 1 with amoxicillin-clavulanate (Synulox 250 mg, Pfizer, Spain) therapy for eight weeks. No response was found in dog No. 2 with any of the antimicrobials alone or combined with metronidazole.

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Section: Discussionmentioning

confidence: 71%

Granulomatous colitis in two French bulldogs unresponsive to fluoroquinolone antimicrobials: a case report

Lucena¹,

Novales²,

Ginel³

2017

Vet. Med. - Czech

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“…4 Clinical presentation, and macroscopic and microscopic findings in the present study were consistent with those described in dogs. 2,3,5 In canine cases, macrophage heterogeneity suggests a difference in function compared with healthy individuals. 6 Although the pathogenesis is not well understood, recent studies have identified E coli in canine patients.…”

Section: Discussionmentioning

confidence: 99%

“…6 Although the pathogenesis is not well understood, recent studies have identified E coli in canine patients. 5,7,8 There are phylogenetic similarities between the E coli strain obtained from Boxer dog GC, and adherent and invasive E coli (AIEC) in human Crohn's disease. 8 AIEC is able to replicate within epithelial cells and macrophages without inducing host cell death.…”

Section: Discussionmentioning

confidence: 99%

Escherichia coli-induced granulomatous colitis in a cat

Matsumoto

Nakashima

Morita

et al. 2019

Journal of Feline Medicine and Surgery Open Reports

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Case summaryA 10-year-old castrated male domestic shorthair cat presented with a 6 month history of diarrhoea that responded poorly to medical treatment. Ultrasonography revealed moderate thickening of the colonic wall (4.8 mm) and right colic and jejunal lymphadenomegalies. Endoscopic examination revealed partial circumferential narrowing of the transverse colon and friable colonic mucosa with multiple haemorrhagic regions. Histopathological and immunohistochemical examinations revealed a large number of Escherichia coli phagocytosed by periodic acid–Schiff-positive macrophages. Bacterial culture also yielded enrofloxacin-sensitive E coli. The cat was initially treated with prednisolone, which resulted in little improvement. Following histopathological examination and bacterial culture, treatment with enrofloxacin was commenced. Antibacterial therapy resulted in remission of the diarrhoea and an increase in body weight within 14 days.Relevance and novel informationGranulomatous colitis (GC) or histiocytic ulcerative colitis has been rarely described in cats. There has only been one previously published case study involving a cat, and the aetiology remains largely unknown. The current article describes the regression of E coli-related GC following antibacterial treatment in a cat. Clinical signs, histopathological appearance and response to enrofloxacin were similar to those in canine GC. The current findings suggest that E coli also plays an important role in the development of feline GC.

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“…Since the first reports in boxer dogs, several single case reports and small case series of GC have also been described in other breeds, mainly French bulldogs (Stokes and others 2001, Tanaka and others 2003, Manchester and others 2013), but also in a mastiff, Alaskan malamute, dobermann, English bulldogs and two beagle dogs (Stokes and others 2001, Hostutler and others 2004, Carvallo and others 2015). Overall, the disease has predominantly been described in the USA, with single cases in Japan, Australia, Brazil and Europe (Van der Gaag and others 1978; Churcher and Watson 1997, German and others 2000, Tanaka and others 2003, Krafft and others 2010, Pavarini and others 2011, Manchester and others 2013).…”

Section: Introductionmentioning

confidence: 99%

Favourable long‐term outcome of granulomatous colitis involving two Escherichia coli strains with multiple antimicrobial resistances in a French bulldog in Germany

Mueller

Dahlem

Henrich

et al. 2016

Vet Record Case Reports

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A two-year-old female French bulldog was presented for chronic large bowel diarrhoea. The dog had been suspected to have granulomatous colitis, but no improvement was noted with enrofloxacin treatment. Diagnosis was confirmed by histology and fluorescent in situ hybridisation. Isolated Escherichia coli strains showed multiple resistances to antimicrobials, including enrofloxacin. Treatment with potentiated amoxicillin and cefovecin resulted in complete resolution of clinical signs within two weeks and treatment was continued for a total of eight weeks. The dog had no signs of large bowel diarrhoea and gained 2 kg of bodyweight within 10 months. This is the first case report of a French bulldog with granulomatous colitis with a favourable long-term outcome despite colonisation with multiresistant adherent-invasive E coli. This case highlights the importance of antimicrobial sensitivity testing from colonic mucosal biopsy samples in canine granulomatous colitis. It should raise awareness of this disease in continental Europe.

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Histiocytic typhlocolitis in two colony Beagle dogs

Cited by 10 publications

References 9 publications

Granulomatous colitis in two French bulldogs unresponsive to fluoroquinolone antimicrobials: a case report

Granulomatous colitis in two French bulldogs unresponsive to fluoroquinolone antimicrobials: a case report

Escherichia coli-induced granulomatous colitis in a cat

Favourable long‐term outcome of granulomatous colitis involving two Escherichia coli strains with multiple antimicrobial resistances in a French bulldog in Germany

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