Histidine kinase‐mediated cross‐regulation of the vancomycin‐resistance operon in Clostridioides difficile
Boris R. Belitsky
Abstract:The dipeptide D‐Ala‐D‐Ala is an essential component of peptidoglycan and the target of vancomycin. Most Clostridioides difficile strains possess the vanG operon responsible for the synthesis of D‐Ala‐D‐Ser, which can replace D‐Ala‐D‐Ala in peptidoglycan. The C. difficile vanG operon is regulated by a two‐component system, VanRS, but is not induced sufficiently by vancomycin to confer resistance to this antibiotic. Surprisingly, in the absence of the VanS histidine kinase (HK), the vanG operon is still induced … Show more
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