Histidine induces lipolysis through sympathetic nerve in white adipose tissue

Yoshimatsu, Hironobu; Tsuda, Kaoru; Niijima, Akira; Tatsukawa, Mari; Chiba, Seiichi; Sakata, Toshiie

doi:10.1046/j.1365-2362.2002.00972.x

Cited by 25 publications

(18 citation statements)

References 26 publications

(38 reference statements)

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“…Elucidating the possible mechanisms through which the skin of different populations (individuals) reacts differently to histamine (injected by a prick or liberated by the action of codeine on mast cells) is a complex problem. Histamine is involved in conditions ranging from neurotransmission, regulation of circulatory function and inflammatory reactions: it also exerts a potent influence on the immune response [5, 7, 8, 9, 10]. Substance P is a mediator located in cutaneous nerve fibers [27].…”

Section: Discussionmentioning

confidence: 99%

“…Through the four histamine receptors (HR 1–4) [7]histamine induces the production of several other mediators, including cytokines, interleukins, leukotrienes, prostaglandins, and substance P. Many of these in turn induce the production of further mediators including histamine itself [8, 9]. The final effect of all these substances depends on the sensitivity of end organs [5]including the ‘non-adrenergic, non-cholinergic’ nerve endings which on histamine stimulation can respond, via an antidromic axon response, with further local production of mediators [10].…”

Section: Introductionmentioning

confidence: 99%

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Skin Reactivity to Histamine and Codeine in Unselected 9-Year-Old Children from Italy, Poland and Libya

Ronchetti

Villa

Bohmerova

et al. 2004

Int Arch Allergy Immunol

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Background: Previous studies have shown that histamine skin reactivity (the dimensions of a skin wheal elicited by a prick with histamine 10 mg/ml) in unselected school children has increased in Italy during the past two decades and is higher in Italy than in Poland. Hence this variable can probably be influenced by a changing or different lifestyle. The aim of this study was to compare skin reactivity to histamine and codeine (a marker of histamine releasability from mast cells) in schoolchildren from countries with different lifestyles. Methods: Six previously unstudied unselected populations of 9-year-old schoolchildren (two each from Poland, Italy, and Libya; n = 863 subjects; 49.0% males) were pricked with two concentrations of histamine (10 and 1 mg/ml) and codeine (90 and 9 mg/ml). Results: The higher concentrations of both pharmacologic agents tested yielded significantly different wheal areas in the three countries: Poland < Italy < Libya (histamine, 11.8, 16.1 and 20.7 mm²; codeine, 9.2, 13.2 and 16.2 mm²; p < 0.001 for all comparisons). The lower concentrations elicited almost matching results. Histamine wheal areas correlated closely with areas elicited by codeine in the same individual: angular coefficients of the histamine to codeine regression lines were 0.535, Italy; 0.551, Libya; 0.612, Poland; and 0.581 for the whole population. More histamine was needed to produce a wheal in Poland than in Libya: a 20-mm² wheal required an injected histamine concentration of about 8.8 mg/ml in Libya, 29.5 mg/ml in Italy and 102.1 mg/ml in Poland. Conclusion: More studies are necessary to explain the observed international differences in skin histamine reactivity and their effect on the prevalence of positive allergen skin tests.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Skin Reactivity to Histamine and Codeine in Unselected 9-Year-Old Children from Italy, Poland and Libya

Ronchetti

Villa

Bohmerova

et al. 2004

Int Arch Allergy Immunol

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“…There have been several studies measuring the changes in the firing rate of sympathetic nerves innervating WAT, all by Niijima and associates (83)(84)(85)(86)(87)(88)(89)(90), showing that a number of stimuli increase sympathetic drive to WAT, including odors, tastes, histamine, leptin, and other factors. This relative paucity of electrophysiological measures of sympathetic nerves to WAT contrasts with that for BAT (for reviews, see Refs.…”

Section: Differential Sympathetic Outflow To Peripheral Tissues Inclumentioning

confidence: 99%

Thematic review series: Adipocyte Biology. Sympathetic and sensory innervation of white adipose tissue

Bartness

Song

2007

Journal of Lipid Research

182

142

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During our study of the reversal of seasonal obesity in Siberian hamsters, we found an interaction between receptors for the pineal hormone melatonin and the sympathetic nervous system (SNS) outflow from brain to white adipose tissue (WAT). This ultimately led us and others to conclude that the SNS innervation of WAT is the primary initiator of lipid mobilization in these as well as other animals, including humans. There is strong neurochemical (norepinephrine turnover), neuroanatomical (viral tract tracing), and functional (sympathetic denervation-induced blockade of lipolysis) evidence for the role of the SNS in lipid mobilization. Recent findings suggest the presence of WAT sensory innervation based on strong neuroanatomical (viral tract tracing, immunohistochemical markers of sensory nerves) and suggestive functional (capsaicin sensory denervation-induced WAT growth) evidence, the latter implying a role in conveying adiposity information to the brain. By contrast, parasympathetic nervous system innervation of WAT is characterized by largely negative neuroanatomical evidence (viral tract tracing, immunohistochemical and biochemical markers of parasympathetic nerves). Functional evidence (intraneural stimulation and in situ microdialysis) for the role of the SNS innervation in lipid mobilization in human WAT is convincing, with some controversy regarding the level of sympathetic nerve activity in human obesity.-Bartness, T. J., and C. K. Song. Sympathetic and sensory innervation of white adipose tissue. J. Lipid Res. 2007. 48: 1655-1672. Supplementary key words obesityObesity is a disease of literally and figuratively enormous proportions (1, 2) and is an independent risk factor for type II diabetes, cardiovascular disease, stroke, and some cancers (3-5). Estimates of the mortality rate of overweight/obese individuals range from ?325,000 deaths per year (6) to as low as ?26,000 (7), making overweight/ obesity either the number two or number seven cause of death in adults in the United States, respectively. Considerable research effort has focused on determining the factors involved in the development of obesity in nonhuman animals; consequently, our understanding of these is substantial, but still far from complete. Somewhat surprisingly, less effort has focused on determining the factors involved in the reversal of obesity in nonhuman animals. We have contributed to these latter efforts by studying the reversal of a naturally occurring seasonal obesity in Siberian hamsters (Phodopus sungorus). In the process of conducting this work, we discovered the importance of the sympathetic nervous system (SNS) in lipid mobilization from white adipose tissue (WAT) as well as more recently realizing the possible importance of the sensory innervation of WAT. Several overviews of the role of the SNS in lipid mobilization were published recently (8-11). To give a better understanding of how we came to the realization that lipid mobilization occurs primarily through the sympathetic innervation of WAT, we will descri...

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“…In addition, antipsychotics may alter sympathetic activity, 10 and histidine, the precursor of histamine, has been reported to stimulate lipolysis in white adipose tissue via activation of the sympathetic nervous system (SNS). 11 Therefore, all these things considered, adipose tissue function appears to constitute a potential direct target of antipsychotics, at least according to their relative histamine H1 receptor antagonism. Furthermore, norepinephrine and epinephrine are key elements by which the SNS regulates thermogenesis, lipolysis and lipid oxidation, as well as adipocyte proliferation and development, via a-and b-adrenoreceptor (AR) activation.…”

Section: Introductionmentioning

confidence: 99%

Alterations of lipid metabolism and gene expression in rat adipocytes during chronic olanzapine treatment

et al. 2007

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Although antipsychotics are established drugs in schizophrenia treatment, they are admittedly known to induce side effects favoring the onset of obesity and worsening its complications. Despite potential involvement of histamine receptor antagonism, or of other neurotransmitter systems, the mechanism by which antipsychotic drugs increase body weight is not elucidated. The aim of the present study was to investigate whether chronic antipsychotic treatments can directly alter the regulation of two main functions of white adipose tissue: lipolysis and glucose utilization. The influence of a classical antipsychotic (haloperidol) was compared to that of two atypical antipsychotics, one known to favor weight gain (olanzapine), the other not (ziprasidone). Cell size, lipolytic capacity and glucose transport activity were determined in white adipocytes of rats subjected to 5-week oral treatment with these antipsychotics. Gene expression of adipocyte proteins involved in glucose transport or fat storage and mobilization, such as glucose transporters (GLUT1 and GLUT4), leptin, matrix metallo-proteinase-9 (MMP9), hormone-sensitive lipase (HSL) and fatty acid synthase (FAS) was also evaluated. Adipocytes from chronic olanzapine-treated rats exhibited decreased lipolytic activity, lowered HSL expression and increased FAS expression. These changes were concomitant to enlarged fat deposition and adipocyte size. Alterations were observed in adipocytes from olanzapinetreated rats whereas the other antipsychotics did not induce any notable disorder. Our results therefore show evidence of an effect of chronic antipsychotic treatment on rat adipocyte metabolism. Thus, impairment of fat cell lipolysis should be considered as a side effect of certain antipsychotics, leading, along with the already documented hyperphagia, to the excessive weight gain observed in patients under prolonged treatment.

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Histidine induces lipolysis through sympathetic nerve in white adipose tissue

Cited by 25 publications

References 26 publications

Skin Reactivity to Histamine and Codeine in Unselected 9-Year-Old Children from Italy, Poland and Libya

Skin Reactivity to Histamine and Codeine in Unselected 9-Year-Old Children from Italy, Poland and Libya

Thematic review series: Adipocyte Biology. Sympathetic and sensory innervation of white adipose tissue

Alterations of lipid metabolism and gene expression in rat adipocytes during chronic olanzapine treatment

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