Histaminergic systems of the limbic complex on learning and motivation

Alvarez, Edgardo O.; Ruarte, Marcela B; Banzán, Arturo M.

doi:10.1016/s0166-4328(01)00213-3

Cited by 33 publications

(25 citation statements)

References 30 publications

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“…() showed that post‐training i.c.v. injection of histamine reduced memory retention in a passive avoidance task and histamine applied into the ventral hippocampus impaired learning processes (Alvarez et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Facilitation of short‐term memory by histaminergic neurons in the nucleus accumbens is independent of cholinergic and glutamatergic transmission

Kraus

Prast

Philippu

2013

British J Pharmacology

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BACKGROUND AND PURPOSEHere, we have investigated whether learning and/or short-term memory was associated with release of ACh and glutamate in the rat nucleus accumbens (NAc). Additionally, neurotransmitter release in the NAc was assessed during facilitation of cognitive processes by antagonists of inhibitory histamine autoreceptors. EXPERIMENTAL APPROACHThe olfactory, social memory test was used in combination with push-pull superfusion of the NAc. A male, juvenile rat was exposed twice to an adult male rat at intervals of 60 or 90 min, and release of ACh and glutamate was determined in the NAc of the conscious adult rat. Histamine receptor antagonists were applied i.c.v. KEY RESULTSFirst exposure of a juvenile rat to an adult rat increased ACh and glutamate release in the NAc of the adult rat. Repetition of exposure after 60 min did not change release of ACh and glutamate, while contact time to recognition (CTR) was shortened. Repetition of exposure after an interval of 90 min prolonged CTR and enhanced accumbal ACh and glutamate release rates. Injection (i.c.v.) of thioperamide (histamine H3 receptor antagonist) together with famotidine (H2 receptor antagonist), 80 min prior to second exposure, diminished CTR and abolished ACh and glutamate release when second exposure was carried out 90 min after the first one. CONCLUSIONS AND IMPLICATIONSHistaminergic neurons per se facilitated short-term memory, without activation of cholinergic and/or glutamatergic neurons in the NAc of rats. Cholinergic and glutamatergic neurons within the NAc contributed to learning but not to recall of memory.

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Section: Discussionmentioning

confidence: 97%

Facilitation of short‐term memory by histaminergic neurons in the nucleus accumbens is independent of cholinergic and glutamatergic transmission

Kraus

Prast

Philippu

2013

British J Pharmacology

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“…However, one report shows an anxiolytic effect rather than an anxiogenic effect for histamine. It has been reported that microinjection of histamine into the nucleus accumbens of rats decreased fear‐like behaviour in the elevated plus‐maze (Alvarez et al 2003). In contrast, Alvarez & Banzan (1986) reported an anxigenic effect for histamine in intrahippocampal injection, suggesting that histamine effects might depend on the site of drug administration.…”

Section: Discussionmentioning

confidence: 99%

Intracerebroventricular Effects of Histaminergic Agents on Morphine‐Induced Anxiolysis in the Elevated Plus‐Maze in Rats

Zarrindast

Rostami²,

Zarei³

et al. 2005

Basic Clin Pharma Tox

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Some reports indicate that morphine can induce anxiolytic effects both in animal and in man. It has also been reported that histaminergic system can interfere with some pharmacological effects of morphine. The effects of histaminergic agents on morphine-induced anxiolysis in rats, using elevated plus-maze were investigated in the present study. Intraperitoneal injection of morphine (3, 6 and 9 mg/kg) induced antianxiety effects. Intracerebroventricular administration of histamine at the doses of (5, 10 and 20 mg/rat) also increased anxiety-related behaviours. Intracerebroventricular injection of pyrilamine, a H 1 receptor antagonist (25, 50 and 100 mg/rat), increased anxiety whereas injection of ranitidine, a H 2 receptor antagonist (5, 10 and 20 mg/rat) at the same site, decreased anxiety. Therefore, it seems that histamine induces anxiogenic response through activation of H 2 receptors, while the response of H 1 blocker may be due to release of histamine. We also evaluated the interactions between morphine and histaminergic agents. Our data show that histamine (10 mg/rat), pyrilamine (50 mg/rat) and ranitidine (5 mg/rat) did not alter the response induced by different doses of morphine (3, 6 and 9 mg/kg). Similarly, a single dose of morphine did not alter the response induced by different doses of histamine (5, 10 and 20 mg/rat), pyrilamine (25, 50 and 100 mg/rat) or ranitidine (5, 10 and 20 mg/rat). In conclusion, the histaminergic system plays an important role in the modulation of anxiety, although in our experiments, no interaction was found between the effects of histaminergic agents and morphine on anxiety-related indices in the elevated plus-maze. This may imply that morphine-induced anxiolysis probably is independent of the histaminergic system.

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“…Recent evidence has clearly established that histamine and its receptors are involved in learning and memory. Numerous experiments using different learning models and species suggest that histamine may be important for several stages of memory formation and memory retrieval during different tasks, and they emphasize the role of histamine in the physiological mechanisms of memory [1,2,23,24,39]. However, these studies have used many different behavioral tasks and produced contradictory results; for instance, both facilitatory and inhibitory effects of neuronal histamine on learning and memory have been described in animal behavior studies [1,6,15,36,46].…”

Section: Introductionmentioning

confidence: 99%

Microinjection of histamine into the cerebellar vermis impairs emotional memory consolidation in mice

Gianlorenço

Canto-de-Souza

Mattioli

2011

Brain Research Bulletin

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The biogenic amine histamine is an important neurotransmitter in the central nervous system that has been implicated in learning and memory processes. Experimental evidence indicates that the role of the cerebellum may be more complex than the simple regulation of motor responses, and recent studies have demonstrated significant involvement of the cerebellum in emotional memory consolidation. This study investigated the effect of histamine microinjected into the cerebellar vermis on emotional memory consolidation in mice in the elevated plus-maze (EPM). The cerebellar vermis of male mice (Swiss Albino) were implanted with guide cannulae. The mice weighed between 25 and 30 g. After three days of recovery, behavioral tests in the EPM were performed on two consecutive days; the testing periods were called, Trial 1 and Trial 2. Immediately after Trial 1, the animals received microinjections of histamine in the cerebellar vermis (0.54, 1.36, 2.72, and 4.07 nmol/0.1 μl). On both days, the test sessions were recorded to enable analysis of behavioral measures. The decrease in open arm exploration (% entries and % time spent in the open arms) in Trial 2 relative to Trial 1 was used as a measure of learning and memory. The data were analyzed using One-way Analysis of Variance (ANOVA) and Duncan's tests. The percentage of open arm entries (%OAE) and the percentage of time spent in the open arms (%OAT) were reduced in Trial 2 relative to Trial 1 for the control group; the same was true for the group that was microinjected with histamine at doses of 0.54 (%OAE and %OAT) and 1.36 nmol (%OAT). However, when the animals received histamine at doses of 2.72 and 4.07 nmol, their open arm exploration did not decrease. No significant changes were observed in the number of enclosed arm entries (EAE), an EPM index of general exploratory activity. These results suggest that there is a dose-dependent inhibitory effect of histamine microinjected into the cerebellar vermis on emotional memory consolidation.

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Histaminergic systems of the limbic complex on learning and motivation

Cited by 33 publications

References 30 publications

Facilitation of short‐term memory by histaminergic neurons in the nucleus accumbens is independent of cholinergic and glutamatergic transmission

Facilitation of short‐term memory by histaminergic neurons in the nucleus accumbens is independent of cholinergic and glutamatergic transmission

Intracerebroventricular Effects of Histaminergic Agents on Morphine‐Induced Anxiolysis in the Elevated Plus‐Maze in Rats

Microinjection of histamine into the cerebellar vermis impairs emotional memory consolidation in mice

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