Histamine Synthesis by Mouse T Lymphocytes through Induced Histidine Decarboxylase

Regulation of Con A ? dependent cytokine production from CD4+ and CD8+ T lymphocytes by autosecretion of histamine

“…Second, treatment of the T cell preparations with anti-Thy-1.2 and complement totally abrogated the histamine production by the T cells (data not shown), confirming our previous findings [3]. Third, histamine is also formed in the culture of T cells obtained even from C57BL/W/W V mice, which are genetically deficient in mast cells and basophils [3].…”

“…All of these studies were conducted with histamine added exogenously to the culture of the immune cells. In contrast, we have recently shown that histamine is produced de novo by the macrophage -T lymphocyte system through histidine decarboxylase (HDC, EC 4.11.22) [1,3,6,7]. In addition, both CD4+ T cells and CD8+ T cells synthesize histamine when activated with Con A, the reactions being strongly enhanced by GM-CSF or IL-3 [4].…”

Regulation of histamine synthesis in mouse CD4+ and CD8+ T lymphocytes

“…We have previously shown that IL-1 production by macrophages is regulated by histamine produced in the cells per se [9]. Evidence is accumulated to indicate that histamine modulates lymphokine synthesis in T lymphocytes; it inhibits synthesis of IL-2 and IFNg in the cells [17].…”

“…It is generally believed that the amine is released from mast cells and basophils upon activation of the cells with allergen-reagin complex. We have previously shown that histamine is also produced de novo by macrophages [7,8] and T lymphocytes [9] through histidine decarboxylase (HDC, EC 4.11.22). In the present study, we examined which subsets of T cells produce histamine.…”

Induction of histidine decarboxylase in type 2 T helper lymphocytes treated with anti-CD3 antibody

“…In addition to mast cells and basophils, several types of cells are reported to have ability to form histamine [6]. Inactive peripheral T-lymphocytes are thought to synthesise only very small amounts of histamine, but activated T-cells might show an increased ability to form histamine.…”