Histamine synthesis and degradation in the chick (Gallus gallus) and the rat (Rattus rattus)

Ishibashi, Teru; Donis, Olga; Fitzpatrick, Dennis; Lee, Nam Soo; Fisher, Hans

doi:10.1016/0306-4492(79)90053-4

Cited by 6 publications

(3 citation statements)

References 6 publications

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“…We have previously reported [10] differences between rats and chicks in the distribution of histamine and its synthesizing and degradative enzymes -histidine decarboxylase (E.C. 4.1.1.22, HDC) and histamine methyltransferase (E.C.…”

Section: Introductionmentioning

confidence: 99%

Effect of age and dietary histidine on histamine metabolism of the growing chick

et al. 1979

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The effect of age and of varying the dietary histidine level, with special emphasis on histamine metabolism, was studied in male, white Leghorn chicks. The birds were fed a 19% amino acid diet with histidine supplied from 0 to 0.8% of dict. In Experiment 1, 7-day-old chicks were fed the experimental diets for 7 days. In Experiment 2, chicks were fed the experimental dlets for different time intervals to equalize their body weight at time of killing. In Experiment 3, blrds were killed at 5, 9, 12 and 15 days of age when their body weights reached 69, 96, 136 and 184 g, respectively. Concentrations of anserine, carnoslne, free-hlstldlne and histamine, and actlvitles of histldine deearboxylase (HDC) and histamine methyl transferase (HMT) were assayed in whole brain, pectoralis major muscle and in proventrlculus of 3 or 4 chicks per treatment group.The following results were obtained: As the level of dietary hlstidlne increased, (1) tissue concentrations of freehistidine and of carnosine increased; (2) the activity of HMT increased; (3) the concentratlon of anserine remained constant; (4) the activity of HDC increased in brain and muscle, but decreased sharply in the proventrieulus; (5) the concentration of histamine decreased. (6) Free-histidine concentration, HDC and HMT activities increased with an increase in age and body weight; however, histamine concentrations decreased with age and body weight. The results point to the possibility that the relatively greater increase in HMT activity compared to HDC may be responsible for the decrease in histamine concentration with increase in dietary histidlne or increased age. The very high HDC activity in the proventrlculus of birds fed low histidine diets may have contributed to the higher histamine concentrations in brain and muscle of blrds fed low versus higher histldine-containing diets.

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Section: Introductionmentioning

confidence: 99%

Effect of age and dietary histidine on histamine metabolism of the growing chick

et al. 1979

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“…I also had the good fortune to have the assistance on this project of Dr. Teru Ishibashi, a professor from Niigata University in Japan, who spent a year and a half in my lab. He studied the interrelationship between dietary histidine and carnosine concentrations in various tissues in the chicken and the rat (21,22).…”

Section: Carnosine Histamine and Wound Healingmentioning

confidence: 99%

From Tryptophan to Hydroxytryptophan: Reflections on a Busy Life

Fisher

2009

Annu. Rev. Nutr.

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Given the very difficult odyssey of my early years, who could have imagined the incredible and successful journey that constituted my life path after age 13? I was born into a Jewish family in Breslau, Germany, right before the rise of Nazism and Hitler's election. After Kristallnacht, when my father was taken to Buchenwald Concentration Camp, we had to leave Germany as soon as possible. The first opportunity came in May of 1939, when we boarded the SS St. Louis bound for Havana, Cuba. Almost all passengers were denied entrance into Cuba, and the ship had to go back to Europe, where I ended up in France. In December of 1939, during World War II, I was fortunate to be able to leave France. This time I made it to Cuba, where my father was already in residence. A year later, my entire family was allowed into the United States. I took advantage of all the educational resources in this land of opportunity. I graduated valedictorian of my high school class and earned a four-year scholarship to Rutgers University, where I obtained a Bachelor of Science degree. I went on to earn a Master's degree from the University of Connecticut and finally a PhD from the University of Illinois. Within two months after graduating from Illinois, I was hired as an assistant professor of nutritional biochemistry at Rutgers, where I enjoyed a most productive research and teaching career. My PhD research involved tryptophan and niacin metabolism in the chick, and upon arrival at Rutgers I continued amino acid studies with the goal of assessing the essential amino acid requirements for egg production. This research was crowned with success and was followed with amino acid requirement studies for maintenance and for growth in rabbits, and ultimately with a reevaluation of requirements in adult humans. An outgrowth of the maintenance requirements led to a series of investigations into the metabolism of histidine, histamine, and carnosine (a histidine-containing dipeptide). Histamine, we found, plays an important role in wound healing and stress management. Pyridoxal phosphate is the cofactor for the enzyme histidine decarboxylase required for histamine synthesis and similarly serves as a cofactor for hydroxytryptophan decarboxylase, the enzyme that is part of the pathway to serotonin synthesis. Investigations into these pathways led to interesting findings: brain concentrations of serotonin could be increased by supplementing the diet of rats with tryptophan and pyridoxine; the elevated brain serotonin levels had behavioral consequences. Alcohol craving, addiction, and withdrawal symptoms are affected by serotonin concentrations in the brain, and alleviation of these conditions can be achieved with simultaneous administration of serotonin and dopamine agonists. In the midst of our early amino acid studies, we serendipitously also became involved with lipid metabolism in relation to atherosclerosis and blood cholesterol in a chicken model. This work led to the recognition that soluble fibers, like pectin, had strong cholesterol-lowering properties that were beneficial in lowering the incidence of coronary plaque formation. The research success that I have enjoyed has been coupled with the gift of three accomplished children who are making important contributions as professionals in their fields of endeavor. My wife and I are also blessed with 10 wonderful grandchildren, our pride and joy!

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“…Other studies suggest that histidine decarboxylase activity is important in controlling the amount of histamine present in rat's gastric mucosa [7,8]. The aim of the present study was (1)-to evaluate the variations in histamine content, histidine decarboxylase and diamine oxydase activity at various level of intestinal tract of the rat and (2)-to investigate the relations between these variations.…”

Section: Introductionmentioning

confidence: 99%

Histamine content, diamine oxydase and histidine decarboxylase activities along the intestinal tract of the rat

1989

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Histamine is widely distributed in the intestine where it is involved in many pathological reactions. The relations between histamine content, diamine oxidase and histidine decarboxylase activity have been investigated along rat's intestine. Results showed significant variations along the intestine. A correlation was observed between histamine and histidine decarboxylase (p less than 0.01), both of them being even in the small intestine (11.8 +/- 2.3 ng/mg ww and 112.5 +/- 21.2 fmoles/hr/mg ww respectively), significantly higher in the caecum (16.3 +/- 1.9 and 178 +/- 20.1) and significantly smaller in the colon (7.3 +/- 1.1 and 65.3 +/- 11.5) than in other intestinal segments. Diamine oxydase activity was higher in ileum (30.7 +/- 7.2 pmoles/min/mg ww) than in jejunum (17.1 +/- 2.8), caecum (4.3 +/- 0.8) and colon (2.6 +/- 2.7), and could not be linked to histamine content. The results fitted in the hypothesis that histamine in rat intestine is mainly located in mast cells where HDC is probably the main enzyme involved in its modulation.

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Histamine synthesis and degradation in the chick (Gallus gallus) and the rat (Rattus rattus)

Cited by 6 publications

References 6 publications

Effect of age and dietary histidine on histamine metabolism of the growing chick

Effect of age and dietary histidine on histamine metabolism of the growing chick

From Tryptophan to Hydroxytryptophan: Reflections on a Busy Life

Histamine content, diamine oxydase and histidine decarboxylase activities along the intestinal tract of the rat

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