Histamine-sensitizing factors from microbial agents, with special reference to Bordetella pertussis

Muñoz, J.; Bergman, R. K.

doi:10.1128/br.32.2.103-126.1968

Cited by 81 publications

(11 citation statements)

References 140 publications

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“…Additional evidence for the central role of the vascular system in histamine sensitivity comes from studies that demonstrate that PTx affects the contractile properties of arteries and results in hypersensitivity to histamine-induced vasodilation [ 23 , 32 ]. A similar effect is also observed after removal of adrenal glands and after blocking of β-adrenergic receptors of mice, suggesting a common catecholamine-dependent mechanism [ 34 ]. The effect of PTx on the vascular system is further supported by its capacity to reduce the blood pressure of spontaneous hypertensive rats [ 35 , 36 , 37 , 38 ].…”

Section: In Vivo Modelsmentioning

confidence: 64%

In Vivo Models and In Vitro Assays for the Assessment of Pertussis Toxin Activity

Hoonakker

2021

Toxins

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One of the main virulence factors produced by Bordetella pertussis is pertussis toxin (PTx) which, in its inactivated form, is the major component of all marketed acellular pertussis vaccines. PTx ADP ribosylates Gαi proteins, thereby affecting the inhibition of adenylate cyclases and resulting in the accumulation of cAMP. Apart from this classical model, PTx also activates some receptors and can affect various ADP ribosylation- and adenylate cyclase-independent signalling pathways. Due to its potent ADP-ribosylation properties, PTx has been used in many research areas. Initially the research primarily focussed on the in vivo effects of the toxin, including histamine sensitization, insulin secretion and leukocytosis. Nowadays, PTx is also used in toxicology research, cell signalling, research involving the blood–brain barrier, and testing of neutralizing antibodies. However, the most important area of use is testing of acellular pertussis vaccines for the presence of residual PTx. In vivo models and in vitro assays for PTx often reflect one of the toxin’s properties or details of its mechanism. Here, the established and novel in vivo and in vitro methods used to evaluate PTx are reviewed, their mechanisms, characteristics and limitations are described, and their application for regulatory and research purposes are considered.

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Section: In Vivo Modelsmentioning

confidence: 64%

In Vivo Models and In Vitro Assays for the Assessment of Pertussis Toxin Activity

Hoonakker

2021

Toxins

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“… G-protein coupled receptor : HRH1 signaling is required for the Bphs phenotype, and all HA receptors belong to the family of G-protein coupled receptors [46]. Pertussis toxin : Bphs is induced in mouse strains by PTX [12]. Vascular permeability (VP): Hypersensitivity to HA exhibits vascular leakage in skin and muscles [34, 35].…”

Section: Resultsmentioning

confidence: 99%

“…We also tested the route of administration of PTX and HA challenge using the intraperitoneal and intravenous routes and found no difference (data not shown). We have not tested the effect of age on Bphs s amongst the various strains; however, work from Munoz and others have reported a significant effect of age [12]. It is possible that some of the strains that are Bphs r will exhibit Histh s as they age or following treatment with complete Freund’s adjuvant [34, 35].…”

Section: Discussionmentioning

confidence: 99%

“…Genotype data (SNPs in both coding and non-coding) of 50 mouse strains (Supplementary Table 1) that were phenotyped for Bphs either by us or described in the literature [12, 15, 17, 19, 40], was retrieved from public databases at the Sanger Institute (https://www.sanger.ac.uk/science/data/mouse-genomes-project) and The Jackson Laboratory (https://phenome.jax.org/). The lack of representation of several inbred strains especially wild-derived strains in these databases were compensated by genotyping using chromosome region capture sequencing [59] as follows:…”

Section: Methodsmentioning

confidence: 99%

“…Further research firmly established HA as a natural constituent of the body and a mediator of anaphylactic shock [5]. There is significant variability in susceptibility to HA-shock among animal species, with guinea pigs and rabbits being highly susceptible, versus mice and rats which are generally remarkably tolerant to in vivo injections of HA [12]. Interestingly, prior exposure to Bordetella pertussis ( B. pertussis ) or purified pertussis toxin (PTX) overcomes HA resistance among a subset of laboratory derived inbred strains of mice [13].…”

Section: Introductionmentioning

confidence: 99%

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Genetic Analysis of Bphse: a Novel Gene Complementing Resistance to Bordetella pertussis-Induced Histamine Sensitization

Raza

Diehl

Case

et al. 2021

Preprint

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Histamine is a bioactive amine associated with a plethora of normal and pathophysiological processes, with the latter being dependent on both genetic and environmental factors including infectious agents. Previously, we showed in mice that susceptibility to Bordetella pertussis and pertussis toxin (PTX) induced histamine sensitization (Bphs) is controlled by histamine receptor H1 (Hrh1/HRH1) alleles. Bphs susceptible and resistant alleles (Bphss/Bphsr) encode for two-conserved protein haplotypes. Given the importance of HRH1 signaling in health and disease, we sequenced Hrh1 across an extended panel of laboratory and wild-derived inbred strains and phenotyped them for Bphs. Unexpectedly, eight strains homozygous for the Bphsr allele phenotyped as Bphss, suggesting the existence of a modifying locus segregating among the strains capable of complementing Bphsr. Genetic analyses mapped this modifier locus to mouse chromosome 6; designated Bphs-enhancer (Bphse), within a functional linkage disequilibrium domain encoding multiple loci controlling responsiveness to histamine (Bphs/Hrh1 and Histh1-4). Interval-specific single-nucleotide polymorphism (SNP) based association testing across 50 laboratory and wild-derived inbred mouse strains and functional prioritization analyses resulted in the identification of candidate genes for Bphse within a ~5.5 Mb interval (Chr6:111.0-116.4 Mb), including Atg7, Plxnd1, Tmcc1, Mkrn2, Il17re, Pparg, Lhfpl4, Vgll4, Rho and Syn2. Taken together, these results demonstrate the power of combining network-based computational methods with the evolutionarily significant diversity of wild-derived inbred mice to identify novel genetic mechanisms controlling susceptibility and resistance to histamine shock.

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Effect of bacterial toxins on human B cell activation I. Mitogenic activity of pertussis toxin

et al. 1990

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Pertussis toxin (PT) was found to elicit an increased thymidine uptake in resting B lymphocytes purified from human peripheral blood. A significant mitogenic effect was detected for toxin concentrations greater than 100 ng/ml (1nM) and a plateau of stimulation was reached at 1000 ng/ml (10 nM). B cell blasts, activated by a first signal such as Staphylococcus aureus Cowan I or insolubilized anti-mu chain antibody, were also stimulated to DNA synthesis by PT in the same range of concentrations. At lower sub-mitogenic concentrations, the toxin potentiated the response to the low-molecular weight B cell growth factor (LMW-BCGF or 12-kDa BCGF), a progression factor for activated B cells. The "A" or catalytic subunit was devoid of any activity on B cells, suggesting the stimulatory effect of the toxin might be associated with the binding or "B" subunit, as it has been shown for T cells. This hypothesis was strengthened by the observation that, as in T cell, the whole toxin but not the "A" promoter, was able to induce calcium influx in these cells. In addition, the purified "B" oligomer alone was found to promote DNA synthesis in B cells. Finally, a fragment of the soluble cleaved form of the CD23 molecule (Fc epsilon RII) could be involved in the process of PT mitogenicity for B cells.

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Histamine-sensitizing factors from microbial agents, with special reference to Bordetella pertussis

Cited by 81 publications

References 140 publications

In Vivo Models and In Vitro Assays for the Assessment of Pertussis Toxin Activity

In Vivo Models and In Vitro Assays for the Assessment of Pertussis Toxin Activity

Genetic Analysis of Bphse: a Novel Gene Complementing Resistance to Bordetella pertussis-Induced Histamine Sensitization

Effect of bacterial toxins on human B cell activation I. Mitogenic activity of pertussis toxin

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