Histamine-secreting microbes are increased in the gut of adult asthma patients

Barcik, Weronika; Pugin, Benoı̂t; Westermann, Patrick; Pérez, Nelson Izquierdo; Ferstl, Ruth; Wawrzyniak, Marcin; Smolińska, Sylwia; Jutel, Marek; Hessel, Edith M.; Michalovich, David; Akdiş, Cezmi A.; Frei, Remo; O’Mahony, Liam

doi:10.1016/j.jaci.2016.05.049

Cited by 120 publications

(102 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In particular, the discovery of reciprocal regulation of T‐cell activity by H1 and H2 receptor activation indicating histamine receptor cross‐talk with cytokines and their expression on numerous immune and inflammatory cells were demonstrated a mostly immune suppressive effects of HR2 on DC, T cells, and basophils . In contrast, immune activator roles of HR1 and HR4 have been shown on many cells . HR2 has been demonstrated to play an essential role in immune regulation by Treg cells and DCs.…”

Section: Histamine and Immune‐regulatory Effects Of Histamine Receptormentioning

confidence: 99%

“…[126][127][128] In contrast, immune activator roles of HR1 and HR4 have been shown on many cells. 128,129 HR2 has been demonstrated to play an essential role in immune regulation by Treg cells and DCs. Gut microbiome has been suggested as one of the sources of histamine and recently histamine-secreting bacteria have been demonstrated.…”

Section: Histamine and Immune-regulatory Effects Of Histamine Recepmentioning

confidence: 99%

See 1 more Smart Citation

Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

Palomares

Akdiş

Martín‐Fontecha

2017

Immunological Reviews

Self Cite

260

300

View full text Add to dashboard Cite

Allergy is a major public health problem with a high socio-economic impact. The number of allergic patients is expected to reach to four billion within two decades when the World's population reaches to 10 billion. Our knowledge on the molecular mechanisms underlying allergic diseases and allergen tolerance induction had significant advances during the last years. Nowadays, it is well accepted that the generation and maintenance of allergen-specific regulatory T cells (Tregs) and regulatory B cells (Bregs) and the involvement of their suppressive cytokines and surface molecules are essential for the induction of allergen tolerance. These mechanisms play essential roles for the restoration of healthy immune responses to allergens in allergen-specific immunotherapy (AIT) and healthy immune response during high-dose antigen exposure in beekeepers and cat owners. AIT remains as the only disease-modifying and curative treatment for allergic diseases and represents a perfect model to investigate the antigen-specific immune responses in humans. A large number of clinical trials demonstrated AIT as an effective treatment in many patients, but it still faces several drawbacks in relation to efficacy, safety, long duration, and patient adherence. Novel strategies to overcome these inconveniences, such as the development of novel adjuvants and alternative routes of administration are being developed. The better understanding of the molecular mechanism governing the generation of Treg and Breg cells during allergen tolerance might well open new avenues for alternative therapeutic interventions in allergic diseases and help better understanding of other immune-tolerance-related diseases.

show abstract

Section: Histamine and Immune‐regulatory Effects Of Histamine Receptormentioning

confidence: 99%

Section: Histamine and Immune-regulatory Effects Of Histamine Recepmentioning

confidence: 99%

Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

Palomares

Akdiş

Martín‐Fontecha

2017

Immunological Reviews

Self Cite

260

300

View full text Add to dashboard Cite

show abstract

“…10,33-43 To date, the predominant focus has been on bacteria, and a number of studies have described asthma-associated differences in the composition of bacterial microbiota found in the respiratory (upper and lower) and gastrointestinal tracts. 10,34-41,44 For example, in the lower respiratory tract a repeating signature is asthma-associated enrichment in members of Proteobacteria, a large phylum representing many species with known potential to cause respiratory illnesses. 33-37,39,40,42,43 These include members of the genera Haemophilus, Moraxella, Neisseria , and Streptococcus (Box 1).…”

Section: Asthmamentioning

confidence: 99%

The microbiome in allergic disease: Current understanding and future opportunities—2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology

Huang

Marsland

Bunyavanich

et al. 2017

Journal of Allergy and Clinical Immunology

Self Cite

288

278

View full text Add to dashboard Cite

PRACTALL is a joint initiative of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology to provide shared evidence-based recommendations on cutting-edge topics in the field of allergy and immunology. PRACTALL 2017 is focused on what has been established regarding the role of the microbiome in patients with asthma, atopic dermatitis, and food allergy. This is complemented by outlining important knowledge gaps regarding its role in allergic disease and delineating strategies necessary to fill these gaps. In addition, a review of progress in approaches used to manipulate the microbiome will be addressed, identifying what has and has not worked to serve as a baseline for future directions to intervene in allergic disease development, progression, or both.

show abstract

“…[94][95][96] High-fat diet-induced microbial alterations increase susceptibility to food allergy, while microbial secretion of histamine in the gut influences the severity of allergic inflammation, and high levels of bacterial-derived short-chain fatty acids protect against sensitization in mice and humans. [97][98][99] Several recent studies have demonstrated that colonization of mice with fecal microbiota from food-allergic children does not protect the animals from food allergy, whereas colonization with microbiota from healthy children was protective. 100,101 While these studies and others suggest that multiple mechanisms might be involved, including but not limited to altered IgA reactivity, induction of regulatory cell subsets, or modification of epithelial metabolism, the consistent important finding is that the intestinal microbiome regulates allergic responses to dietary antigens and targeting the microbiome might be therapeutically effective in food allergy.…”

Section: Antigenmentioning

confidence: 99%

Recent developments and highlights in food allergy

Eiwegger

Hung

Diego

et al. 2019

Allergy

Self Cite

View full text Add to dashboard Cite

The achievement of long-lasting, safe treatments for food allergy is dependent on the understanding of the immunological basis of food allergy. Accurate diagnosis is essential for management. In recent years, data from oral food challenges have revealed that routine allergy testing is poor at predicting clinical allergy for tree nuts, almonds in particular. More advanced antigen-based tests including component-resolved diagnostics and epitope reactivity may lead to more accurate diagnosis and selection of therapeutic intervention. Additional diagnostic accuracy may come from cellular tests such as the basophil activation test or mast cell approaches. In the context of clinical trials, cellular tests have revealed specific T-cell and B-cell populations that are more abundant in food-allergic individuals with distinct mechanistic features.Awareness of clinical markers, such as the ability to eat baked forms of milk and egg, continues to inform the understanding of natural tolerance development.Mouse models have allowed for investigation into multiple mechanisms of food allergy including modification of epithelial metabolism, and the induction of regulatory cell subsets and the microbiome. Increasing numbers of children who underwent food immunotherapy enlarged the body of evidence on mechanisms and predictors of treatment success. Experimental immunological markers in conjunction with clinical determinants such as lower age and lower initial specific IgE appear to be of benefit.More research on the optimal dose, preparation, and route of application integrating a high-level safety and efficacy is demanded. Alternatively, biologics blocking TSLP, IL-33, IL-4 and IL-13, or IgE may help to achieve that. K E Y W O R D Sallergy treatment, biologics, food allergy, immune tolerance, immunotherapy | 2357 EIWEGGER Et al.

show abstract

Histamine-secreting microbes are increased in the gut of adult asthma patients

Cited by 120 publications

References 9 publications

Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

Mechanisms of immune regulation in allergic diseases: the role of regulatory T and B cells

The microbiome in allergic disease: Current understanding and future opportunities—2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology

Recent developments and highlights in food allergy

Contact Info

Product

Resources

About