Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy

Kashiwakura, Jun Ichi; Ando, Tomoaki; Matsumoto, Kenji; Kimura, Miho; Kitaura, Jiro; Matho, Michael H.; Zajonc, Dirk M.; Ozeki, Toshinaga; Ra, Chisei; MacDonald, Susan; Siraganian, Reuben P.; Broide, David H.; Kawakami, Yuko; Kawakami, Toshiaki

doi:10.1172/jci59072

Cited by 68 publications

(88 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They mapped the binding site on TCTP and used corresponding peptides to block its interaction with the 'cognate' IgE antibody. They also showed that these Ig-interacting TCTP/HRF peptides inhibited IgE/HRFinduced mast cell activation in vitro and other allergenic symptoms in a mouse model in vivo (Kashiwakura et al 2012). This finding demonstrates that TCTP/ HRF has a proinflammatory role in asthma and skin hypersensitivity and also that it can be considered a potential therapeutic target.…”

Section: Participation In Immunological Reactionsmentioning

confidence: 98%

“…These include B-cells (IL-1, IL-8 release), basophils (IL-4, IL-13 release), T-cells (inhibition of IL-2, IL-13 release), bronchial epithelial cells (IL-8, GM-CSF release) and GM-CSF-primed eosinophils (IL-8 release) (Macdonald 2012b). The potential binding of TCTP to IgE antibodies was a matter of debate (Wantke et al 1999), but a more recent paper showed that the dimerised form of TCTP is able to bind to a subset of IgE and IgG molecules (Kashiwakura et al 2012). 2.…”

Section: Tctp As Extracellular 'Signaling Molecule' In Immune Reactionsmentioning

confidence: 99%

“…A recent detailed study demonstrated that a subset of both IgE and IgG antibodies are able to bind TCTP/HRF (Kashiwakura et al 2012). Dimerisation of TCTP as a prerequisite for its cytokine-like activity was shown before (Kim et al 2009a(Kim et al , 2013a).…”

Section: Participation In Immunological Reactionsmentioning

confidence: 99%

See 2 more Smart Citations

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Bommer

2017

Results and Problems in Cell Differentiation

View full text Add to dashboard Cite

The Translational Controlled Tumour Protein TCTP (gene symbol TPT1, also called P21, P23, Q23, fortilin or histamine-releasing factor, HRF) is a highly conserved protein present in essentially all eukaryotic organisms and involved in many fundamental cell biological and disease processes. It was first discovered about 35 years ago, and it took an extended period of time for its multiple functions to be revealed, and even today we do not yet fully understand all the details. Having witnessed most of this history, in this chapter, I give a brief overview and review the current knowledge on the structure, biological functions, disease involvements and cellular regulation of this protein. TCTP is able to interact with a large number of other proteins and is therefore involved in many core cell biological processes, predominantly in the response to cellular stresses, such as oxidative stress, heat shock, genotoxic stress, imbalance of ion metabolism as well as other conditions. Mechanistically, TCTP acts as an anti-apoptotic protein, and it is involved in DNA-damage repair and in cellular autophagy. Thus, broadly speaking, TCTP can be considered a cytoprotective protein. In addition, TCTP facilitates cell division through stabilising the mitotic spindle and cell growth through modulating growth signalling pathways and through its interaction with the proteosynthetic machinery of the cell. Due to its activities, both as an anti-apoptotic protein and in promoting cell growth and division, TCTP is also essential in the early development of both animals and plants. Apart from its involvement in various biological processes at the cellular level, TCTP can also act as an extracellular protein and as such has been involved in modulating whole-body defence processes, namely in the mammalian immune system. Extracellular TCTP, typically in its dimerised form, is able to induce the release of cytokines and other signalling molecules from various types of immune cells. There are also several examples, where TCTP was shown to be involved in antiviral/antibacterial defence in lower animals. In plants, the protein appears to have a protective effect against phytotoxic stresses, such as flooding, draught, too high or low temperature, salt stress or exposure to heavy metals. The finding for the latter stress condition is corroborated by earlier reports that TCTP levels are considerably up-regulated upon exposure of earthworms to high levels of heavy metals. Given the involvement of TCTP in many biological processes aimed at maintaining cellular or whole-body homeostasis, it is not surprising that dysregulation of TCTP levels may promote a range of disease processes, foremost cancer. Indeed a large body of evidence now supports a role of TCTP in at least the most predominant types of human cancers. Typically, this can be ascribed to both the anti-apoptotic activity of the protein and to its function in promoting cell growth and division. However, TCTP also appears to be involved in the later stages of cancer progression, such ...

show abstract

Section: Participation In Immunological Reactionsmentioning

confidence: 98%

Section: Tctp As Extracellular 'Signaling Molecule' In Immune Reactionsmentioning

confidence: 99%

See 1 more Smart Citation

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

Bommer

2017

Results and Problems in Cell Differentiation

View full text Add to dashboard Cite

show abstract

“…Subsequently, TPT1/TCTP was characterized as the histamine releasing factor (HRF) and studied for its extrinsic function in allergy and inflammation [4][5][6][7].…”

Section: Initial Discoveriesmentioning

confidence: 99%

TPT1/ TCTP-regulated pathways in phenotypic reprogramming

Amson

Pece

Marine

et al. 2013

Trends in Cell Biology

103

112

View full text Add to dashboard Cite

“…Furthermore, highly cytokinergic IgE antibodies with polyreactivity to autoantigens, including thyroperoxidase, which could induce mast cell activation, have been demonstrated in the sera from patients with atopic dermatitis (52). The role of non-immunoglobulin histamine releasing factors that can interact with IgE in CSU remains unclear (53).…”

Section: Participation Of Ige In the Pathogenesis Of Chronic Urticariamentioning

confidence: 99%

Justification for IgE as a therapeutic target in chronic spontaneous urticaria

Sánchez‐Borges

Capriles-Hulet

Caballero‐Fonseca

et al. 2017

Eur Ann Allergy Clin Immunol

View full text Add to dashboard Cite

Summary Monoclonal anti-IgE antibodies (omalizumab) are able to induce clinically significant benefits in patients with severe chronic spontaneous urticaria (CS). Those results led clinicians and investigators to reconsider a possible pathogenic role not previously supported for IgE and its receptors in this disease, and to investigate additional approaches for understanding its pathogenesis. IgE antibodies to unknown environmental allergens able to trigger chronic urticaria are not generally regarded as the etiologic factor for the disease. Other proposed mechanisms for the production of wheals and angioedema in CSU include IgG autoantibodies and CD4-positive T cells directed to the high-affinity

show abstract

Histamine-releasing factor has a proinflammatory role in mouse models of asthma and allergy

Abstract: IgE

Cited by 68 publications

References 67 publications

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

The Translational Controlled Tumour Protein TCTP: Biological Functions and Regulation

TPT1/ TCTP-regulated pathways in phenotypic reprogramming

Justification for IgE as a therapeutic target in chronic spontaneous urticaria

Contact Info

Product

Resources

About