Histamine Releasers. III. Dibasic Acid Amides of 4-Phenyl-4-aminomethylpiperidines

Abstract

Carcinoma S••' 16.4-2 .118/46.6 zh 3 .29 64 " Given every 2 days. * Treatment begins 7 days after tumor transplantation in rats. • Treatment begins S days after tumor transplantation in mice. d Treatment begins 3 days after tumor transplantation in mice. * Treatment begins 24 hr after tumor transplantation in mice. ! Treatment begins 24 hr after tumor transplantation in rats. 20 ml of EtOIl were shaken under hydrogen at atmospheric pressure. The theoretical amount of H, was absorbed after 1.5 hr. The catalyst was removed by filtration, and the solvent was distilled under vacuum giving t.ti g (79.6% ) of VII, mp 115 117°a fter recrystallization from petroleum ether.