Histamine-release induced by 7s nervegrowth factor of mouse submandibular salivary glands

Sugiyama, Katsumi; Suzuki, Y.; Furuta, Hiroaki

doi:10.1016/0003-9969(85)90031-7

Cited by 29 publications

(7 citation statements)

References 10 publications

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“…The experiments on the whole organism, along with the information on the expanding spectrum of action and the biological role of NGF in the organism (Kaliunov, 1984(Kaliunov, , 1986Levi-Montalcini and Angeletti, 1977;Marx, 1986;Boyle et al, 1985;Banks, 1984;Li et al, 1979;Lillien and Claude, 1985;Bruni et al, 1982;Mazurek et al, 1986;Pearce and Thompson, 1986;Segiyama et al, 1985) do not deal with all facets of the final effect. In our analysis we describe three interlocking components as the basis for the described responses, without giving the details of how they work.…”

Section: Discussionmentioning

confidence: 99%

“…The occurrence of specialized receptors on lymphocytes (Thorpe et al, 1987) and the suggestion of the presence of these receptors in mast cell membranes, by which they are subject to dose-dependent degranulation in the presence of NGF (Bruni et al, 1982;Mazurek et al, 1986;Pearce and Thompson, 1986;Segiyama et al, 1985), permit the assumption of a direct effect of the agent on some immunocompetent elements. It is probably responsible for the stimulation of lymphocyte proliferation in culture with very low concentrations, as compared with PHA.…”

Section: IIImentioning

confidence: 99%

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The immunomodulatory effect of nerve growth factor

Abramchik¹,

Yermakova²,

Kaliunov³

et al. 1988

J of Neuroscience Research

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A prolonged application of nerve growth factor (NGF) to neonatal prepuberal rats induced selective hypertrophy and hyperfunction of ganglionic sympathetic neurons. This was accompanied by higher density and fluorescence intensity of varicose adrenergic fibers and terminals in the immunocompetent organs, total increase of catecholamines in them, catecholamine diffusion into the intercellular space, and their accumulation by macrophages and mast cells. The plaque-forming and lymphocyte blast transformation responses were activated, signs of increased lymphocyte migration to peripheral lymphoid tissues appeared, and histamine concentration in the thymus and spleen increased. All of the foregoing indicate the immunomodulatory effect of NGF and the dependence of immune responsiveness of the organism on the functional state of the adrenergic moiety. The net effect of the increase is attributed to non-specific protein sensitization, changes in the sympathetic (and, probably, somatic) nervous system, and direct action on immunocompetent cells.

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Section: Discussionmentioning

confidence: 99%

Section: IIImentioning

confidence: 99%

The immunomodulatory effect of nerve growth factor

Abramchik¹,

Yermakova²,

Kaliunov³

et al. 1988

J of Neuroscience Research

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“…For example, application of nM NGF to PC12 cells results in increased cytosolic Ca2+ concentration within minutes, due to enhanced Ca2+ influx as well as release from internal stores (Lazarovici et al, 1989). Furthermore, nanomolar NGF increases the Ca2+-dependent release of dopamine and norepinephrine from PC 12 cells within a few minutes (Nikodijevic et al, 1990) and the release of histamine from mast cells within minutes in vitro in the presence of lysophosphatidyl serine (Bruni et al, 1982;Sugiyama et al, 1985;Mazurek et al, 1986). In addition, NGF enhancement of endogenously released adenosine effects on PC12 cells (Race and Wagner, 1985) may account for previous reports that NGF rapidly stimulates CAMP levels in PC12 and other types of neurons (Nikodijevic et al, 1975;Schubert et al, 1978;Skaper et al, 1979).…”

mentioning

confidence: 81%

Nerve growth factor rapidly prolongs the action potential of mature sensory ganglion neurons in culture, and this effect requires activation of Gs-coupled excitatory kappa-opioid receptors on these cells

Shen

Crain

1994

J. Neurosci.

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Application of low concentrations (pM-nM) of NGF to mouse dorsal root ganglion (DRG)-spinal cord explants in long-term organotypic cultures rapidly prolongs the duration of the Ca(2+)-dependent component of the action potential (APD) in a major subset of DRG neurons that were previously shown to have characteristic responsiveness to exogenous opioids. These NGF-elicited excitatory modulating effects are blocked by pretreatment of the DRG neurons with monoclonal antibodies to rodent NGF receptors. NGF-induced APD prolongation is also prevented by the opioid receptor antagonist naloxone and the specific kappa-opioid antagonist nor-binaltorphimine (but not by specific mu- and delta-opioid antagonists). The results suggest that NGF stimulates the release of endogenous opioids (e.g., dynorphin) from DRG neurons and that prolongation of the APD occurs secondarily by activation of excitatory kappa-opioid receptor functions on these same or nearby cells. NGF-induced release of small quantities of opioids by DRG neurons would be expected to prolong the APD in view of the remarkable sensitivity of these neurons to the excitatory effects of extremely low (fM-nM) concentrations of exogenous opioid agonists. NGF-induced APD prolongation is blocked by the same cholera toxin A or B subunit treatments previously shown to block Gs coupling and GM1 ganglioside regulation of excitatory opioid receptors, respectively. These in vitro studies suggest that excitatory opioid receptor-mediated functions may play a role in mediating some types of rapid NGF-induced hyperalgesic and other physiologic effects on the nervous system.

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“…241 NGF can support rat PMC survival, 242 the development by mouse BMCMCs of features of "connective tissue type MCs", 243 and the growth of rat PMCs. 241,244 Furthermore, NGF can induce degranulation of rat skin MCs 245 and PMCs [246][247][248][249] and can induce chemotaxis in rat PMCs. 250 Moreover, correlations have been reported for numbers of MCs and levels of NGF mRNA levels in bronchial biopsies from patients with asthma, 251 vernal keratoconjunctivitis, 252 or systemic sclerosis.…”

Section: Ngfmentioning

confidence: 98%

Mast cells as sources of cytokines, chemokines, and growth factors

Mukai

Tsai

Saito

et al. 2018

Immunological Reviews

514

508

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Mast cells are hematopoietic cells that reside in virtually all vascularized tissues and that represent potential sources of a wide variety of biologically active secreted products, including diverse cytokines and growth factors. There is strong evidence for important non-redundant roles of mast cells in many types of innate or adaptive immune responses, including making important contributions to immediate and chronic IgE-associated allergic disorders and enhancing host resistance to certain venoms and parasites. However, mast cells have been proposed to influence many other biological processes, including responses to bacteria and virus, angiogenesis, wound healing, fibrosis, autoimmune and metabolic disorders, and cancer. The potential functions of mast cells in many of these settings is thought to reflect their ability to secrete, upon appropriate activation by a range of immune or non-immune stimuli, a broad spectrum of cytokines (including many chemokines) and growth factors, with potential autocrine, paracrine, local, and systemic effects. In this review, we summarize the evidence indicating which cytokines and growth factors can be produced by various populations of rodent and human mast cells in response to particular immune or non-immune stimuli, and comment on the proven or potential roles of such mast cell products in health and disease.

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Histamine-release induced by 7s nervegrowth factor of mouse submandibular salivary glands

Cited by 29 publications

References 10 publications

The immunomodulatory effect of nerve growth factor

The immunomodulatory effect of nerve growth factor

Nerve growth factor rapidly prolongs the action potential of mature sensory ganglion neurons in culture, and this effect requires activation of Gs-coupled excitatory kappa-opioid receptors on these cells

Mast cells as sources of cytokines, chemokines, and growth factors

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