Histamine release and vascular changes induced by neuropeptides

Foreman, J. C.; Jordan, Chris

doi:10.1007/bf01967311

Cited by 178 publications

(71 citation statements)

References 37 publications

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“…In neurogenic inflammation, actions of mast cells can be triggered by the release of transmitters from sensory nerves, mainly neuropeptides (Foreman and Jordan, 1983). Products of mast cells, including leukotrienes, have also been shown to evoke the release of substance P in the airways (Martins et al, 1991;Saria, 1988).…”

Section: Discussionmentioning

confidence: 99%

Substance P can stimulate prostaglandin D2 and leukotriene C4 generation without granule exocytosis in murine mast cells

Karimi

Kool

Nijkamp

et al. 2004

European Journal of Pharmacology

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Mast cells play a central role in immediate type hypersensitivity and inflammatory events. Activation of mast cells not only can result in the release of preformed granule-associated mediators generally followed by de novo synthesis of lipid-derived substances. In the present study, we show that mast cell can be activated to release lipid mediators in absence of granule exocytosis. Primary cultured murine mast cells were stimulated with substance P and produced leukotriene C 4 , and prostaglandin D 2 without the release of the granule-associated enzyme hhexosaminidase. Indomethacin and nordihydroguaiaretic acid caused complete inhibition of arachidonic metabolite generation. Leukotriene C 4 and prostaglandin D 2 production was blocked by genistein, a specific inhibitor of tyrosine kinases, and bisindolylmaleimide, a protein kinase C inhibitor, indicating a role for both phosphorylation pathways in the substance P-stimulated lipid mediator production. We suggest that the cytokine microenvironment of the mast cell determines whether mast cell stimulation leads to only lipid mediator release or full activation. Analysis of granule-associated mediators only might underestimate the role of mast cell activation under (patho)physiological conditions. D

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Section: Discussionmentioning

confidence: 99%

Substance P can stimulate prostaglandin D2 and leukotriene C4 generation without granule exocytosis in murine mast cells

Karimi

Kool

Nijkamp

et al. 2004

European Journal of Pharmacology

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“…In a similar model, antidromic impulses in substance-P-containing primary afferent neurones would release substance P which, in turn, could release histamine from mast cells and produce vasodilatation (Foreman & Jordan, 1983). In our model, the cholinergic histamine release could contribute to maintain local homoeostasis in the heart and in the ileum (i.e.…”

Section: Release Of Histamine By Vagal Stimulationmentioning

confidence: 99%

The release of histamine by parasympathetic stimulation in guinea‐pig auricle and rat ileum.

Bani-Sacchi¹,

Barattini²,

Bianchi³

et al. 1986

The Journal of Physiology

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SUMMARY1. Two preparations, a segment of rat ileum and the vagally innerved guinea-pig auricles, have been used in an analysis of the responses to vagal or to electrical field stimulation.2. The responses to parasympathetic stimulation were depressed by atropine and by tetrodotoxin, and potentiated by eserine.3. Supramaximal stimulation (10-20 Hz) resulted in increased release of acetylcholine and histamine, both in rat ileum and guinea-pig auricles.4. The release of histamine after parasympathetic stimulation did not exhibit tachyphylaxis, and it was not reproduced by non-parasympathetic stimuli.5. In both preparations, atropine produced a significant, dose-related reduction of histamine measured in the bath fluid after stimulation, while eserine increased histamine output.6. A significant diminution of mast cell granules metachromasia was observed in guinea-pig auricles and in rat intestine after parasympathetic stimulation.7. The possibility is discussed that acetylcholine released by parasympathetic stimulation would in turn evoke the secretion of histamine from tissue mast cells.

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“…Although type I hypersensi tive reactions mediated by IgE are thought to be the main reason for histamine release, proteins and peptides secret ed by activated eosinophils and neutrophils during the anaphylactic reaction are also responsible for the hista mine release from mast cells (13,14). When the spreading of inflammation beyond the point of stimulation takes place via the axon reflex, neuropeptides, such as SP, secreted from nerve endings, induce histamine release from mast cells (1). In this study, we selected SP as a hista mine releaser, and we examined the effects of emedastine on histamine release.…”

Section: Discussionmentioning

confidence: 99%

“…In particular, histamine release induced by neuro peptides such as substance P (SP) has been discussed ex tensively in recent years (1)(2)(3)(4)(5)(6). Intracutaneous injection of histamine produces circumscribed edema, wheals and flares; an axon reflex model has been suggested for the spread of flares.…”

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Effects of Heparin on the Inhibitory Activities of Human Urinary Trypsin Inhibitor (Ulinastatin) on Trypsin, Chymotrypsin and Leukocyte Elastase

Saito

Hagihara

Igarashi

et al. 1993

Japanese Journal of Pharmacology

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ABSTRACT-The inhibitory effects of emedastine difumarate on histamine release were studied in rat peritoneal mast cells. Emedastine significantly inhibited substance P (SP)-induced histamine release at con centrations above 10-9 M in the presence of extracellular Ca2+ and at concentrations above 10-" M in its absence. At concentrations of 10-8 M or higher, emedastine significantly inhibited SP-induced Ca" release from intracellular Ca stores and SP-induced 45Ca uptake into mast cells. Emedastine also inhibited passive peritoneal anaphylaxis in rats and guinea pigs. We conclude that the clinical antiallergic effects of emedastine involve the inhibition of histamine release and that this inhibition is mediated by the inhibition of Ca" release from intracellular Ca stores and the inhibition of Ca" influx into mast cells.

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Histamine release and vascular changes induced by neuropeptides

Cited by 178 publications

References 37 publications

Substance P can stimulate prostaglandin D2 and leukotriene C4 generation without granule exocytosis in murine mast cells

Substance P can stimulate prostaglandin D2 and leukotriene C4 generation without granule exocytosis in murine mast cells

The release of histamine by parasympathetic stimulation in guinea‐pig auricle and rat ileum.

Effects of Heparin on the Inhibitory Activities of Human Urinary Trypsin Inhibitor (Ulinastatin) on Trypsin, Chymotrypsin and Leukocyte Elastase

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