Histamine receptors in the vasculature of the rabbit ear

Zs, Ercan; Rk, Türker

doi:10.1007/bf00510818

Cited by 14 publications

(5 citation statements)

References 11 publications

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“…results in dilatation of the vessels. In most other species investigated, there is a predominance of H2-receptor participation in the vasodilator responses to histamine and a Hl-receptor mediated vasoconstriction in the external carotid vascular bed (Edvinsson & Owman, 1975;Saxena, 1975;Duckworth et al, 1976;Parsons & Owen, 1973;Ercan & Turker, 1975). However, in human temporal arteries only vasodilatation was seen, and this response seemed mainly to be mediated via H2-receptors.…”

Section: Discussionmentioning

confidence: 99%

“…In carotid vascular bed have been studied in man, histamine produces a headache often animals both in vitro and in situ. In the rabbit and associated with increased pulsation in the cat histamine has been found to be a vasotemporal artery, and a rise in blood, and oc-constrictor agent (Furukawa, 1954; Owen, 1973, Ercan & Turker, 1975, Edvinsson & Owman, 1975. This response seems to be a reflection of a balance between a histamine H1-receptor mediated vasoconstriction and a histamine H2-receptor mediated vasodilatation (Glover et al, 1973;Edvinsson & Owman, 1975).…”

Section: Introductionmentioning

confidence: 99%

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Pharmacological characterization of histamine receptors in the human temporal artery.

Ottosson

Jansen

Edvinsson

1989

Brit J Clinical Pharma

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1 The subtypes of histamine-receptors which mediate dilatation of small human temporal arteries have been characterized in vitro using 'selective' agonists and antagonists. 2 Dilatory responses were studied after preconstriction with prostaglandin F2a since contraction was not seen at histamine concentrations up to 104 M. Histamine caused a concentration-related relaxation of cerebral vessels with an IC50 value of 2.8 ± 0.6 x 1i7 M. 3 Cimetidine caused a parallel shift to the right of the histamine concentration-response curve whereas mepyramine was without observable effect. This suggests the presence of histamine H2-receptors only. However, combined treatment with mepyramine and cimetidine caused a more marked displacement of the concentration-response curve to the right. Schild analysis indicated that in situations of near complete blockade of the histamine H1-receptor subtypes, simple competitive antagonism at H2-receptors can be revealed with a pA2 value of 6.58 for cimetidine. The apparent pA2 value for mepyramine was 8.58.4 The 'selective' Hl-receptor agonists pyridylethylamine, 2-methylhistamine and thiazolylethylamine, and the H2-receptor agonists dimaprit, impromidine and 4-methylhistamine all mimicked the histamine response, but all except impromidine were less potent than histamine. The order of potency was impromidine > thiazolylamine > 4-Mehistamine > 2-Me-histamine > dimaprit > pyridylethylamine > tele-Me-histamine. 5 These results indicate that the histamine-induced dilatation in small human temporal arteries is mediated by both H1-and H2-receptors and that the latter subtype of histamine receptors predominates.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pharmacological characterization of histamine receptors in the human temporal artery.

Ottosson

Jansen

Edvinsson

1989

Brit J Clinical Pharma

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“…Over the past few years, influences of histamine on cat and rat gastric (Guth & Smith, 1978a;Harvey, Owen & Shaw, 1980), rat, rabbit, cat and dog mesenteric (Flynn & Owen, 1975;Angus & Korner, 1977;Pawlik, Tague, Tepperman, Millar & Jacobson, 1977;Guth & Smith, 1978b), rabbit and pig coronary (Coruzzi, Bongrani & Bertaccini, 1979;Hagen & Paegelow, 1980), rabbit renal (Angus & Korner, 1977), rabbit ear (Ercan & Turker, 1975), cat and dog cerebral vasculatures (Edvinsson & Owman, 1975;Toda, 1977;Wahl & Kuschinsky, 1979) and cat and dog blood pressure (Black, Owen & Parsons, 1975) have been described. Some of these authors have postulated from the results of experiments in situ that both H1-and H2-receptors participate in a common response, such as a vasodilatation, an increase in the blood flow and a fall of the blood pressure (Black et al, 1975;Flynn & Owen, 1975;Angus & Korner, 1977;Pawlik etal., 1977;Guth & Smith, 1978a, b;Harvey et al, 1980).…”

Section: Introductionmentioning

confidence: 99%

Different Mechanisms of Action of Histamine in Isolated Arteries of the Dog

Konishi

Toda

Yamamoto

1981

British J Pharmacology

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1 In helically-cut strips of dog coronary, superior mesenteric, right gastro-epiploic and renal arteries contracted with prostaglandin F2X (PGF21), histamine produced a dose-related relaxation, while, in contrast, the amine caused only a contraction of cerebral arterial strips. 2 The contractile response of cerebral arteries to histamine was attenuated by chlorpheniramine (10-6M) but was unaffected by cimetidine (10-5M). Relaxant responses to histamine of coronary and renal arteries were significantly attenuated by treatment with cimetidine and to a similar extent by combined treatment with cimetidine and chlorpheniramine. Chlorpheniramine alone was ineffective. 3 In mesenteric and gastro-epiploic arteries, relaxant responses to histamine were attenuated only slightly by cimetidine. Chlorpheniramine slowed the development of histamine-induced relaxations but did not alter the magnitude of the relaxations. Combined treatment with these Hl-and H2-antagonists attenuated the histamine-induced relaxations to an appreciably greater extent than treatment with cimetidine alone. 4 It may be concluded that the cerebroarterial contraction induced by histamine is mediated through HI-receptors and the relaxations of coronary and renal arteries induced by histamine are mediated through H2-receptors. It appears that Hl-and H2-receptors interact with each other to produce potentiation of histamine-induced relaxations of mesenteric and gastro-epiploic arteries.

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“…A dual action o f the amine has been observed in the vasculature o f the isolated perfused kidney (3) and ear (7) o f this species. In addition, it has been shown that histamine induces a biphasic response in the mean arterial pressure of urethane-anesthetized rabbits.…”

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confidence: 99%

Histamine Receptors in the Isolated Rat Stomach Fundus and Rabbit Aortic Strips

Ercan

Türker

1977

Pharmacology

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The effects of histamine and 4-methylhistamine (a selective H₂-agonist) were studied on the isolated rat stomach fundus and rabbit aortic strips superfused with Krebs’ solution. The contraction induced by histamine was found to be mediated via mepyramine-sensitive H₁, while the relaxation induced by the amine through metiamide-sensitive H₂-receptors in both smooth muscles. Prior addition of metiamide to the superfusion medium caused an apparent dose-related potentiation in the response to histamine on the aortic strip but not on the stomach fundus strip. The relaxation produced by histamine on the aortic strip demonstrated when the muscle was pretreated with mepyramine and contracted by angiotensin II or serotonin. Metiamide competitively inhibited the relaxation induced by histamine but not by papaverine in both smooth muscles. 4-Methylhistamine produced only a relaxation in the rat stomach fundus which could be competitively inhibited by metiamide. This analog had no agonistic property in the aortic strip. From these results it was concluded that histamine H₁- and H₂-receptors are present in both smooth muscles. The predominant contractile effect of histamine is mediated through H₁-receptors and the relaxing effect of the amine through H₂-receptors.

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Histamine receptors in the vasculature of the rabbit ear

Cited by 14 publications

References 11 publications

Pharmacological characterization of histamine receptors in the human temporal artery.

Pharmacological characterization of histamine receptors in the human temporal artery.

Different Mechanisms of Action of Histamine in Isolated Arteries of the Dog

Histamine Receptors in the Isolated Rat Stomach Fundus and Rabbit Aortic Strips

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