Histamine receptors in the human ureter

Bertaccini, G.; Zappia, L; E, Bezzi; Potenzoni, D.

doi:10.1016/s0031-6989(83)80057-5

Cited by 15 publications

(3 citation statements)

References 7 publications

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“…H 1 -receptors have been shown to be predominant over H 2 -receptors with regard to efficacy of coupling in the human ureteral muscle. However, administration of both H 1 -and H 2 -receptor antagonists was not able to modify the basal tone and motility of ureteral strips [59] . Similar to humans, histamine had a spasmogenic effect in the canine ureter [60] , causing contraction via H 1 -receptors in the sheep ureterovesical junction [61] and inducing relaxation via H 2 -receptors in the buffalo ureter [62] .…”

Section: Histaminementioning

confidence: 78%

Physiology and Pharmacology of the Human Ureter: Basis for Current and Future Treatments

Canda

Turna²,

Cinar

et al. 2007

Urol Int

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Introduction: This article sets out to be a review regarding agents that affect contraction and relaxation of the ureter in order to establish a basis for current and future treatments for upper urinary tract obstruction. Material and Methods: A complete review of the English literature using MEDLINE was performed between 1960 and 2007 on ureter physiology and pharmacology with special emphasis on signal transduction mechanisms involved in the contractile regulation of the human ureter. Results: Activation of muscarinic and adrenergic receptors increases the amplitude of ureteral contractions. The sympathetic nerves modulate the contractions by α-adrenoceptors and relaxation by β-adrenoceptors. The purinergic system is important in sensory/motor functions and ATP is an important non-adrenergic non-cholinergic (NANC) agent causing contraction. Nitric oxide (NO) is a major inhibitory NANC neurotransmitter causing relaxation. Serotonin causes contraction. Prostaglandin-F₂α contracts whereas prostaglandin-E₁/E₂ relaxes the ureter. Phosphodiesterases (PDE) and the Rho-kinase pathway have recently been identified in the human ureter. PDE-IV inhibitors, K⁺ channel openers, calcium antagonists, α₁-adrenoceptor antagonists and NO donors seem to be promising drugs in relieving obstruction and facilitating stone passage. Conclusions: Further understanding of the ureteral function and pharmacology may lead to the discovery of promising new drugs that could be useful in relieving ureteral colic, facilitating spontaneous stone passage, preparing the ureter for ureteroscopy as well as acting adjunctive to extracorporeal shock-wave lithotripsy.

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Section: Histaminementioning

confidence: 78%

Physiology and Pharmacology of the Human Ureter: Basis for Current and Future Treatments

Canda

Turna²,

Cinar

et al. 2007

Urol Int

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“…This results suggest that using Chlorpheniramine along with Morphine can be more effective that morhpine alone in managing patients with acute renal colic. After determination of histamine receptors in ureter by Bertaccini et al it has been suggested that they can make peristalsis effect during renal colic (7). After that, use of histamine 1 receptor antagonists in management of patients with renal colic were evaluated.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Effect of Morphine-Chlorpheniramine Combined Versus Morphine Alone in Alleviating Acute Renal Colic Pain: A Randomized Clinical Trail

Ziapor

Motamed

Verki

et al. 2017

Jundishapur J Nat Pharm Prod

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Background: Renal colic is a significant painful condition that needs urgent and influential treatment by proper analgesics. The studies showed that histamine receptors expressed in the ureter and causes strong peristaltic contractions in the ureter. The concept of this study assumed that Chlorpheniramine, propylamine H1-receptor antagonist (antihistamine), may have an effective role in management of renal colic pain.

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“…In‐vitro experiments have shown histamine to be one of the most potent stimulators of ureteric peristalsis [2,3]. Histological and immunohistochemical studies show a uniform and abundant distribution of histamine receptors along the entire ureter, in particular H1 receptors [4,5]. Electron microscopic studies of human ureter exposed to urine have shown degranulation of mast cells with release of histamine, producing forceful peristaltic contractions simulating renal colic [6].…”

mentioning

confidence: 99%