Histamine Receptor Expression in the Gastrointestinal Tract of Dogs

Schwittlick, Ulrike; Junginger, Johannes; Hahn, Kerstin; Habierski, A.; Hewicker‐Trautwein, M.

doi:10.1111/ahe.12229

Cited by 4 publications

(3 citation statements)

References 38 publications

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“…Likewise, histamine receptors (HR) 1, 2 and, 4 have been found to be present along the whole gastrointestinal tract in dogs, and H4R messenger RNA was detected in the canine duodenum and in colonic mucosae (enterocytes, immune cells, lamina propria, and submucosal plexus). This finding is noteworthy because histamine is involved in modulating GI motility, with high levels of this mediator and of HR mRNA found in men affected by IBS (38).…”

Section: Relation Between Stress and Altered Motility In Dogsmentioning

confidence: 81%

Is irritable bowel syndrome also present in dogs?

Cerquetella¹,

Rossi²,

Spaterna³

et al. 2018

Tierarztl Prax Ausg K

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SummaryIrritable bowel syndrome (IBS) in humans is described as the recurrent presence of gastrointestinal signs, without gross histopathologic evidence of inflammation and of other morphologic lesions; however, it is a syndrome not unanimously defined in veterinary medicine. There is some evidence that dysmotility could be related to stressors in some dogs that present with clinical signs (e.g. chronic idiopathic large-bowel diarrhea) that share overlapping aspects with human IBS. The authors hypothesize that an IBS-like condition, similar to that described in humans, might also be present in dogs. Nevertheless, the diagnostic path for canine IBS needs to be further elucidated and its pathogenesis better defined for a more rational therapeutic approach.

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Section: Relation Between Stress and Altered Motility In Dogsmentioning

confidence: 81%

Is irritable bowel syndrome also present in dogs?

Cerquetella¹,

Rossi²,

Spaterna³

et al. 2018

Tierarztl Prax Ausg K

View full text Add to dashboard Cite

show abstract

“…Instead, H2, H3 and H4 receptors are involved in vascular permeability and airway constriction 22 neuro-inflammatory disease 23 and release of inflammatory signaling cascades consisting of cytokines and cell chemotaxis. 19,24 Like humans, H1 and H2 receptors are also distributed throughout various tissues in dogs, including all sections of the gastrointestinal (GI) tract, 25,26 bronchial and tracheal smooth muscle, 27 and atrioventricular tissue. 28 Histamine release mediates an increase in vascular permeability and vasodilation via the activation of histamine receptors including H1 and H2, however the response varies between the 2 receptor subtypes.…”

Section: Discussionmentioning

confidence: 99%

Polysorbate 80-Induced Anaphylactoid Reaction and the Effects on Cardiovascular Function: Dose Threshold and Species Comparison

Pouliot¹,

Bussiere

Coppi

et al. 2022

Int J Toxicol

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Polysorbate 80 (PS80) is commonly used in pre-clinical formulations. The dose threshold for cardiovascular (CV) changes and hypersensitivity reaction in the dog was assessed and compared to other species. PS80 was administered by intravenous (IV) bolus (.5, 1 mg/kg), IV infusion (.3, .5, 1, 3 mg/kg), subcutaneous (SC) injection (5, 10, 15 mg/kg) and oral gavage (10 mg/kg) to dogs with CV monitoring. Monkeys and minipigs received PS80 by IV infusion at 3 mg/kg. Plasma histamine concentration was measured following PS80 IV infusion and with diphenhydramine pre-treatment in dogs only. In dogs, PS80 was not associated with CV changes at doses up to 15 mg/kg SC and 10 mg/kg oral, but decreased blood pressure and increased heart rate with IV bolus at ≥ .5 mg/kg and IV infusion at ≥ 1.0 mg/kg and decreased body temperature with IV infusion at 3 mg/kg was observed. Transient edema and erythema were noted with all administration routes, in all three species including doses that were devoid of CV effects. In monkeys and minipigs, PS80 did not induce CV, cutaneous or histamine concentration changes. These results suggest that mild, transient skin changes occur following PS80 administration at doses that are not associated with CV effects in the dogs. In dogs, the cardiovascular effect threshold was <.5 mg/kg for IV bolus, .3 mg/kg for IV infusion, 15 mg/kg for SC injection, and 10 mg/kg for oral administration. Monkey and minipig were refractory to PS80-induced histamine release at 3 mg/kg by IV infusion over 15 minutes.

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“…One immunohistochemical analysis of different species demonstrated the presence of 5-HT2A receptors on enterocytes and Paneth cells (64). Histamine H1 and H2 receptors were also identified in canine enterocytes (65, 66); however, whether this expression is limited to dogs needs to be clarified. Finally, trace amine-associated receptors (TAARs) such as TAAR1 and TAAR2, for which ligands include tyramine, phenethylamine, and other biogenic amines (11), are also shown to exist in human EC cells (67) and the mouse intestinal mucosa (68).…”

Section: Biogenic Amine Receptors On Gut Epithelial Cellsmentioning

confidence: 99%

Biogenic Amines: Signals Between Commensal Microbiota and Gut Physiology

Sudo

2019

Front. Endocrinol.

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There is increasing interest in the interactions among the gut microbiota, gut, and brain, which is often referred to as the “microbiota-gut-brain” axis. Biogenic amines including dopamine, norepinephrine, serotonin, and histamines are all generated by commensal gut microorganisms and are suggested to play roles as signaling molecules mediating the function of the “microbiota-gut-brain” axis. In addition, such amines generated in the gut have attracted attention in terms of possible clues into the etiologies of depression, anxiety, and even psychosis. This review covers the latest research related to the potential role of microbe-derived amines such as catecholamine, serotonin, histamine, as well as other trace amines, in modulating not only gut physiology but also brain function of the host. Further attention in this field can offer not only insight into expanding the fundamental roles and impacts of the human microbiome, but also further offer new therapeutic strategies for psychological disorders based on regulating the balance of resident bacteria.

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Histamine Receptor Expression in the Gastrointestinal Tract of Dogs

Cited by 4 publications

References 38 publications

Is irritable bowel syndrome also present in dogs?

Is irritable bowel syndrome also present in dogs?

Polysorbate 80-Induced Anaphylactoid Reaction and the Effects on Cardiovascular Function: Dose Threshold and Species Comparison

Biogenic Amines: Signals Between Commensal Microbiota and Gut Physiology

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