Histamine Receptor Antagonism of Intolerance to Alcohol in the Oriental Population

Miller, Norman S.; Goodwin, Donald W.; Jones, Fowler C.; Pardo, Manuel P.; Anand, M M; Gabrielli, William F.; Hall, T B

doi:10.1097/00005053-198711000-00003

Cited by 22 publications

(7 citation statements)

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“…Histamine antagonists, especially H1 blockers, attenuate alcohol flushing in white subjects with (Stowell et al, 1986) or without (Tan et al, 1979) ALDH inhibition. Similarly, histamine antagonism efficiently blocks the Asian flushing (Miller et al, 1987) and AcH-mediated bronchoconstriction in Asian asthmatics (Myou et al, 1993), who usually carry the ALDH2*2 allele (Sakurai et al, 1992). Altogether, the current evidence suggests that both peripheral and central mechanisms are involved in the histamineassociated alcohol sensitivity (Miller et al, 1987;Myou et al, 1993;and review by Zimatkin and Anichtchik, 1999).…”

Section: Acute Effects Of Alcohol Drinkingmentioning

confidence: 99%

The Role of Acetaldehyde in the Actions of Alcohol (Update 2000)

Eriksson

2001

Alcoholism Clin & Exp Res

226

116

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Background: Recent advances in the field of acetaldehyde (AcH) research have raised the need for a comprehensive review on the role of AcH in the actions of alcohol. This update is an attempt to summarize the available AcH research.Methods: The descriptive part of this article covers not only recent research but also the development of the field. Special emphasis is placed on mechanistic analyses, new hypotheses, and conclusions.Results: Elevated AcH during alcohol intoxication causes alcohol sensitivity, which involves vasodilation associated with increased skin temperature, subjective feelings of hotness and facial flushing, increased heart and respiration rate, lowered blood pressure, sensation of dry mouth or throat associated with bronchoconstriction and allergy reactions, nausea and headache, and also reinforcing reactions like euphoria. These effects seem to involve catecholamine, opiate peptide, prostaglandin, histamine, and/or kinin mechanisms. The contribution of AcH to the pathological consequences of chronic alcohol intake is well established for different forms of cancer in the digestive tract and the upper airways. AcH seems to play a role in the etiology of liver cirrhosis. AcH may have a role in other pathological developments, which include brain damage, cardiomyopathy, pancreatitis, and fetal alcohol syndrome. AcH creates both unpleasant aversive reactions that protect against excessive alcohol drinking and euphoric sensations that may reinforce alcohol drinking. The protective effect of AcH may be used in future treatments that involve gene therapy with or without liver transplantation.Conclusions: AcH plays a role in most of the actions of alcohol. The individual variability in these AcH-mediated actions will depend on the genetic polymorphism, not only for the alcohol and AcHmetabolizing enzymes but also for the target sites for AcH actions. The subtle balance between aversive and reinforcing, protecting and promoting factors will determine the overall behavioral and pathological developments.

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Section: Acute Effects Of Alcohol Drinkingmentioning

confidence: 99%

The Role of Acetaldehyde in the Actions of Alcohol (Update 2000)

Eriksson

2001

Alcoholism Clin & Exp Res

226

116

View full text Add to dashboard Cite

show abstract

“…Histamine antagonists, especially H1 blockers, attenuate alcohol flushing in white subjects with (Stowell et al, 1986) or without (Tan et al, 1979) ALDH inhibition. Similarly, histamine antagonism efficiently blocks the Asian flushing (Miller et al, 1987) and AcH-mediated broncho-constriction in Asian asthmatics (Myou et al, 1993), who usually carry the ALDH2*2 allele (Sakurai et al, 1992). Altogether, the current evidence suggests that both peripheral and central mechanisms are involved in the histamineassociated alcohol sensitivity (Miller et al, 1987;Myou et al, 1993;and review by Zimatkin and Anichtchik, 1999).…”

Section: Acute Effects Of Alcohol Drinkingmentioning

confidence: 99%

The Role of Acetaldehyde in the Actions of Alcohol (Update 2000)

2001

Alcoholism: Clinical and Experimental Research

137

102

View full text Add to dashboard Cite

AcH plays a role in most of the actions of alcohol. The individual variability in these AcH-mediated actions will depend on the genetic polymorphism, not only for the alcohol and AcH-metabolizing enzymes but also for the target sites for AcH actions. The subtle balance between aversive and reinforcing, protecting and promoting factors will determine the overall behavioral and pathological developments.

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“…Miller et al. [38] were able to demonstrate the blocking of alcohol intolerance symptoms by both histamine H 1 ‐ and H 2 ‐receptor antagonists. Myou et al.…”

Section: Ethanol and Worsening Asthmamentioning

confidence: 99%