Histamine receptor 2-mediated growth-differentiation factor-15 expression is involved in histamine-induced melanogenesis

Lee, Hye Ja; Park, Mi Kyung; Lee, Eun Ji; Kim, You Lee; Kim, Hyun Ji; Kang, Joo‐Hyon; Kim, Hwan Mook; Lee, Ai Young; Lee, Chang Hoon

doi:10.1016/j.biocel.2012.08.020

Cited by 19 publications

(25 citation statements)

References 27 publications

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“…Skin inflammatory or autoimmune diseases are frequently accompanied by hypo‐/hyperpigmentation disorders, which may be modulated by complex interactions between diverse types of immune cells and epidermal melanin units. Inflammatory cytokines produced from these immune cells function not only by direct effects but also by indirect or combinational effects on melanogenesis …”

Section: Immune Cellsmentioning

confidence: 99%

“…Histamine is thought to play an important role in the induction of PIH. It stimulates melanogenesis through histamine receptor 2 via complex signalling pathways, including PKA phosphorylation in normal human melanocytes, and ERK activation in human melanoma SK‐MEL‐2 cells and mouse melanoma B16F10 cells …”

Section: Immune Cellsmentioning

confidence: 99%

“…Inflammatory cytokines produced from these immune cells function not only by direct effects but also by indirect or combinational effects on melanogenesis. 8,59,78 Histamine has been suggested to be an inflammatory mediator, the main source of which is mast cells. Histamine is thought to play an important role in the induction of PIH.…”

Section: Immune Cellsmentioning

confidence: 99%

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Paracrine regulation of melanogenesis

Yuan

Jin

2018

Br J Dermatol

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Melanocytes are generally characterized by the basic ability of melanin synthesis and transfer to adjacent keratinocytes. This constitutes an individual skin phenotype and provides epidermal protection from various stimuli, such as ultraviolet irradiation, through a complex process called melanogenesis, which can be regulated by autocrine or paracrine factors. Recent evidence has revealed the paracrine effects of keratinocytes on melanogenesis by secreting cytokines, including α-melanocyte stimulating hormone and endothelin-1. In addition to keratinocytes, there are other types of cells in the skin, such as fibroblasts and immune cells, which are also actively involved in the regulation of melanocyte behaviour through the production of paracrine factors. In addition, extracellular matrix proteins, which are secreted mainly by skin-resident cells, not only play direct roles in regulating melanocyte morphology and functions but also provide structural support between the epidermis and dermis to control the distribution of various secreted cytokines from keratinocytes and/or fibroblasts, which are potentially involved in the regulation of melanogenesis. Moreover, understanding the origin of melanocytes (neural crest cells) and the presence of nerve endings in the epidermis can reveal the intimate contact between melanocytes and cutaneous specific nervous system proteins. Melanocytes are associated with all these networks with corresponding receptors expressed on the cell surface. In this review, we provide an overview of recent advances in determining the intimate relationships between melanocytes and their surrounding elements, which provide insights into the complex nature of the regulation of melanogenesis.

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Section: Immune Cellsmentioning

confidence: 99%

Section: Immune Cellsmentioning

confidence: 99%

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Paracrine regulation of melanogenesis

Yuan

Jin

2018

Br J Dermatol

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“…Skin pigmentation disorders including vitiligo and melasma can result from problems that arise in melanocyte proliferation, differentiation, melanogenesis, migration or dendricity (Lee et al ., 2012b). Pigmentation modulation is important to aesthetics and quality of life.…”

Section: Discussionmentioning

confidence: 99%

“…This skin pigmentation may result from several steps including melanocyte proliferation, differentiation, melanogenesis, migration or increases in dendricity (Park et al ., 2009). In melanocytes, melanins are synthesized within melanosomes which contain three major pigment enzymes: tyrosinase, tyrosinase-related protein (TRP-1), and TRP-2 (Lee et al ., 2012b). The expression of these proteins is regulated transcriptionally by the microphthalmia associated transcription factor (MITF).…”

Section: Introductionmentioning

confidence: 99%

Involvement of Transglutaminase-2 in α-MSH-Induced Melanogenesis in SK-MEL-2 Human Melanoma Cells

Kim

Lee

Park

et al. 2014

Biomolecules & Therapeutics

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Skin hyperpigmentation is one of the most common skin disorders caused by abnormal melanogenesis. The mechanism and key factors at play are not fully understood. Previous reports have indicated that cystamine (CTM) inhibits melanin synthesis, though its molecular mechanism in melanogenesis remains unclear. In the present study, we investigated the effect of CTM on melanin production using ELISA reader and the expression of proteins involved in melanogenesis by Western blotting, and examined the involvement of transglutaminase-2 (Tgase-2) in SK-MEL-2 human melanoma cells by gene silencing. In the results, CTM dose-dependently suppressed melanin production and dendrite extension in α-MSH-induced melanogenesis of SK-MEL-2 human melanoma cells. CTM also suppressed α-MSH-induced chemotactic migration as well as the expressions of melanogenesis factors TRP-1, TRP-2 and MITF in α-MSH-treated SK-MEL-2 cells. Meanwhile, gene silencing of Tgase-2 suppressed dendrite extension and the expressions of TRP-1 and TRP-2 in α-MSH-treated SK-MEL-2 cells. Overall, these findings suggested that CTM suppresses α-MSH-induced melanogenesis via Tgase-2 inhibition and that therefore, Tgase-2 might be a new target in hyperpigmentation disorder therapy.

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Pathogenesis of melasma

Khanna

Nowah

Morris

et al. 2023

Dermatological Reviews

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To adequately guide future therapies, it is important to elucidate the pathogenesis of melasma. Chronic ultraviolet (UV) radiation exposure, hormonal stimulation, and genetic predisposition play a role in melasma. A widely accepted theory for the pathogenesis of melasma is the increase of melanin through UV, which leads to the upregulation of melanin stimulating receptors (MSR) such as melanocortin-1 receptors (MC1R), resulting in increased hormone binding and melanin production. Furthermore, there are similarities between the histopathologic presentation of melasma and solar elastosis, a hallmark of photo-aged skin. These overlaps include altered basement membrane, increased vascularization, and increased mast cell count. There is significant data showing greater degree of solar elastosis in the melasma skin compared to the perilesional skin.Additionally, an etiologic factor in the pathogenesis of melasma is hormonal exposure to estrogen. Melasma has increased prevalence among menstruating women, women on oral contraceptives, and pregnant women. In melasma lesions, studies have shown an increased number of estrogen receptors and progesterone receptors in the dermis and epidermis, respectively. Previously, increased melanogenesis was thought to be the sole contributing factor to the pathogenesis of melasma but more recently, aberrant vasodilation and angiogenesis have been found to play a role. Nitric oxide, a potent vasodilator, was found to be overexpressed at the dermal-epidermal junction and was hypothesized to contribute to melasma through stimulation of tyrosinase and increasing vascularity. In conclusion, the various mechanisms implicated in melasma include melanocyte dysfunction, solar elastosis, mast cell dysfunction, hormonal influence, vascular transformation, and basement membrane damage.

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Histamine receptor 2-mediated growth-differentiation factor-15 expression is involved in histamine-induced melanogenesis

Cited by 19 publications

References 27 publications

Paracrine regulation of melanogenesis

Paracrine regulation of melanogenesis

Involvement of Transglutaminase-2 in α-MSH-Induced Melanogenesis in SK-MEL-2 Human Melanoma Cells

Pathogenesis of melasma

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