Histamine Metabolism in Man

Summary Histamine levels in whole blood and plasma from the umbilical arteries and veins, together with circulating basophil and eosinophil counts, were determined in two groups of healthy infants, “term” and “pre‐term”. No significant arteriovenous differences were found except in the basophil counts of the “pre‐term” group. This result was consistent with the finding of significant arteriovenous correlations for all these sets of estimations except the basophil counts in the “pre‐term” group. No significant differences were found between the mean values in either group except for the difference between the mean basophil counts for venous blood. Plasma histamine levels (arterial and venous) were usually less than the lowest limit of the method (1.8 ng/ml). Very small amounts of histamine were detected, however, in one venous and one arterial specimen in the “pre‐term” group, but these did not produce a significant difference between the levels for the two groups of infants.

Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Histamine and granulocytes in the umbilical cord blood of infants at birth

Mitchell

Porter

1970

“…This allowed us to determine the renal clearance of ImAA and ImAA-C in man and rats. We also measured the levels of N3 methylhistamine, another metabolite of histamine (Lindell & Westling, 1966;Axelrod, 1971) at the same time and examined the changes in histamine metabolism after administration of various drugs and during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Determination of imidazole acetic acid and its conjugate(s) levels in urine, serum and tissues of rats: studies on changes in their levels under various conditions

Imamura

Maeyama

Wada

et al. 1984

A convenient and reproducible method for assay of imidazole acetic acid (ImAA) was developed as a modification of that described previously (Watanabe et al., 1983). ImAA conjugate(s) (ImAA‐C), mainly consisting of imidazole acetic acid riboside, could be measured by this method after its hydrolysis to ImAA. The ImAA and ImAA‐C levels in various tissues of rats were measured and the effects of various agents on these levels were studied. The renal clearance values of ImAA‐C in rats and man were similar to the creatinine clearance values, but those of ImAA were 1/40 of those of ImAA‐C, suggesting that the latter is readily excreted in the urine. Consistent with this idea, the urinary excretion of ImAA‐C was found to increase much more than that of other histamine metabolites during late pregnancy, when the foetus produces much histamine.

“…To our knowledge it has so far not been possible to demonstrate the formation of histamine from C"-L-histidine in man in vivo (Brown, Silva, McDonald, Snyder & Kies, 1960;Lindell & Westling, 1966). Especially remarkable is the failure to demonstrate "C-activity in urinary histamine metabolites after giving labelled histidine to patients with mastocytosis (Demis & Brown, 1961), since this disease is held to be associated with an increased rate of histamine formation.…”

Section: Introductionmentioning

confidence: 99%

Histamine formation from ¹⁴C‐l‐histidine in man

Berg

Granérus

Johansson

et al. 1972

Self Cite

Summary1. "C-L-histidine was given i.v. to one normal subject and two patients with chronic myelocytic leukaemia. Urinary excretion of histamine and two of its metabolites methylhistamine and methylimidazoleacetic acid, total as well as "IC-labelled, was measured, as well as blood "IC-histamine. In addition the total urinary and pulmonary elimination of "IC was followed. 2. Total "IC elimination was high during the first days, then declined slowly except for a plateau at the 10th-14th day in the two patients. There was a measurable elimination even after some months.3. "IC-histamine appeared in the blood of the leukaemic patient, whereas in the normal subjects the values were hardly measurable.4. The leukaemic patients excreted much more of the two "IC-labelled histamine metabolites than the normal subject. The difference in excretion of the "IC-labelled metabolites was largest around the 12th day after the infusion of "C-L-histidine. 5. The results indicate that the leukaemic patients formed at least 20 times more histamine daily than the normal subject.