Histamine: Its metabolism and localization in mammary gland

Maśliński, Cz.; Kierska, D.; Fogel, W. A.; Kinnunen, Anu; Panula, Pertti

doi:10.1016/0742-8413(93)90206-z

Cited by 23 publications

(22 citation statements)

References 17 publications

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“…No differences were seen in the cisternal wall samples. The mean concentrations were of the same magnitude as found by Maslinski and coworkers in rats and mice, but lower than in cows [1].Ketotifen pretreatment caused drowsiness, whereas FUB 181 maleate caused cardiac arrhythmias (auscultation) and increased gastrointestinal motility. Before oxytocin injection, the mean milk flow rate from one mammary gland of the goats was about 0.3 ml/min.…”

supporting

confidence: 66%

“…

IntroductionHigh concentrations of histamine have been found in the mammary glands of several species [1,2]. Mammary tissue also contains components of histamine synthesis and metabolism [1,2].

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mentioning

confidence: 99%

“…Mammary tissue also contains components of histamine synthesis and metabolism [1,2]. In 1958, Harris reported that histamine causes contraction of myoepithelial cells of alveoli and small ducts in the mammary gland [3].…”

mentioning

confidence: 99%

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Is histamine involved in milk ejection in goats?

Eriksson¹,

Fogel

Eklund-Uusitalo³

et al. 1999

Inflammation Research

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IntroductionHigh concentrations of histamine have been found in the mammary glands of several species [1,2]. Mammary tissue also contains components of histamine synthesis and metabolism [1,2]. In 1958, Harris reported that histamine causes contraction of myoepithelial cells of alveoli and small ducts in the mammary gland [3]. Histamine could thus contribute to milk ejection together with oxytocin. Later Maslinski's group showed that histamine stimulates milk release from mouse mammary gland slices [4]. The aim of this study was to compare the histamine contents of the mammary gland of dairy goats in different lactation stages and to evaluate the possible role of histamine in milk ejection. Materials and methodsSeven adult Finnish dairy goats of a mean body weight of 43 kg were used. The study plan was approved by the local committee on animal experiments.For tissue sampling, a lactating and a non-lactating goat were anaesthetized with medetomidine (20 mg/kg, Domitor, Orion-Farmos, Turku, Finland) and ketamine (1 mg/kg, Ketalar, Parke-Davis) i.m. Tissue samples were immediately frozen in isopenthane, kept on dry ice and then stored at -70°C. They were homogenised in five volumes of 0.4 N HClO 4 , and histamine was analysed by HPLC [5].Serial milk samples were taken from six goats in the late lactation stage by hand milking to dryness. The goats were given oxytocin (7.5 IU, Synox, Orion-Farmos) with or without pretreatment with histamine receptor antagonists 15 min earlier, in a random order with at least two days between the experiments. The antagonists used were: H 1 antagonist ketotifen (1 mg/kg, Polfa, Poland), H 2 antagonist famotidine (0.5 mg/kg, Pepcidin, MSD) and H 3 antagonist FUB 181 maleate (0.5 mg/kg, gift from Prof. Schunack, Freie Universität Berlin, Germany). All drugs were given intravenously.The results are given as means ± SEM. Analysis of variance was used for the evaluation of statistical differences. Results and discussionHistamine concentrations both in the glandular part and in the milk cisternal walls of the mammary glands were very high (Fig. 1). The mean content from six different locations of glandular tissue in the lactating goat was significantly higher than in the corresponding samples of the non-lactating goat. No differences were seen in the cisternal wall samples. The mean concentrations were of the same magnitude as found by Maslinski and coworkers in rats and mice, but lower than in cows [1].Ketotifen pretreatment caused drowsiness, whereas FUB 181 maleate caused cardiac arrhythmias (auscultation) and increased gastrointestinal motility. Before oxytocin injection, the mean milk flow rate from one mammary gland of the goats was about 0.3 ml/min. Oxytocin increased the milk flow significantly. There were no statistically significant differences in the response to oxytocin between different Inflamm. res. 48, Supplement 1 (1999) S90-S91 Fig. 1. Histamine concentrations in the glandular part and the cisternal wall of goat mammary gland. The mean ± SEM from six different locations of g...

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supporting

confidence: 66%

“…

IntroductionHigh concentrations of histamine have been found in the mammary glands of several species [1,2]. Mammary tissue also contains components of histamine synthesis and metabolism [1,2].

…”

mentioning

confidence: 99%

See 1 more Smart Citation

Is histamine involved in milk ejection in goats?

Eriksson¹,

Fogel

Eklund-Uusitalo³

et al. 1999

Inflammation Research

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“…[3][4][5] In mammary gland, histamine plays a critical role in growth regulation, differentiation and functioning during development, pregnancy and lactation. [6][7][8] Histamine is a biogenic amine involved in the regulation of different physiological processes. It is synthesized from L-histidine by a specific enzyme, L-histidine decarboxylase (HDC, EC 4.1.1.22).…”

Section: Introductionmentioning

confidence: 99%

The role of histamine in human mammary carcinogenesis: H3 and H4 receptors as potential therapeutic targets for breast cancer treatment.

Medina¹,

Croci²,

Crescenti³

et al. 2008

Cancer Biology & Therapy

108

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There is increasing evidence that describes a histamine role in normal and cancer cell proliferation. To better understand the importance of histamine in breast cancer development, the expression of histamine H3 (H3R) and H4 (H4R) receptors and their association with proliferating cell nuclear antigen (PCNA), histidine decarboxylase (HDC) and histamine content were explored in mammary biopsies. Additionally, we investigated whether H3R and

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“…Histamine plays a critical role in the pathologic and physiologic aspects of the mammary gland, regulating cell growth, differentiation and functioning during development, pregnancy and lactation. Among monoamines, histamine demonstrates the greatest proliferative activity in breast cancer Malinski et al, 1993;Wagner et al, 2003). Furthermore, histamine is increased in plasma and cancerous tissue derived from breast cancer patients compared to healthy group which is associated to an enhanced histidine decarboxylase (HDC) activity and a reduced diaminooxydase (DAO) activity that determine an imbalance between the synthesis and degradation of this monoamine.…”

Section: Histamine Receptors In Breast Cancermentioning

confidence: 99%