Histamine-induced vasodilation and vasoconstriction in the mesenteric resistance artery of the rat

Jin, Hang; Koyama, Toshihiro; Hatanaka, Yukako; Akiyama, Shinji; Takayama, Fusako; Kawasaki, Hiromu

doi:10.1016/j.ejphar.2005.10.060

Cited by 36 publications

(40 citation statements)

References 18 publications

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“…Histamine-induced plasma extravasation (oedema) is mainly processed by activation of H1-histaminergic receptors and, to a lesser extent, H2 receptors expressed in the skin vessels of both rodents [34,35] and humans [36,37]. Herein, the simultaneous i.d.…”

Section: Discussionmentioning

confidence: 99%

“…Histamine exerts its inflammatory effects, in part, through NO generation in situ [35], since the blockade of NOS significantly inhibited histamine-induced plasma extravasation in human nasal airway [42]. Interestingly, Ali and co-workers [43] demonstrated that low concentration of H2S or spontaneous H2S donors reversed histamine, but not isoprenaline-induced vasodilatation, possibly via a direct chemical reaction between H2S and NO, which may lead to the formation of a nitrosothiol [44] or even nitroxyl species (NO-/HNO) [45] of poor vasorelaxant activities.…”

Section: Discussionmentioning

confidence: 99%

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Protective effects of exogenous and endogenous hydrogen sulfide in mast cell-mediated pruritus and cutaneous acute inflammation in mice

Rodrigues

Ekundi-Valentim

Florenzano

et al. 2017

Pharmacological Research

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Protective effects of exogenous and endogenous hydrogen sulfide in mast cell-mediated pruritus and cutaneous acute inflammation in mice.Pharmacological Research http://dx.doi.org/10. 1016/j.phrs.2016.11.006 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Graphical abstract RESEARCH PAPER ABSTRACTThe recently described 'gasomediator' hydrogen sulfide (H2S) has been involved in pain mechanisms, but its effect on pruritus, a sensory modality that similarly to pain acts as a protective mechanism, is poorly known and controversial. The effects of the slowreleasing (GYY4137) and spontaneous H2S donors (Na2S and Lawesson's reagent, LR)were evaluated in histamine and compound 48/80 (C48/80)-dependent dorsal skin pruritus and inflammation in male BALB/c mice. Animals were intradermally (i.d.)injected with C48/80 (3 µg/site) or histamine (1 µmol/site) alone or co-injected with Na2S, LR or GYY4137 (within the 0.3 -100 nmol range). The involvement of endogenous H2S and KATP channel-dependent mechanism were also evaluated. Pruritus was assessed by the number of scratching bouts, whilst skin inflammation was evaluated by the extravascular accumulation of intravenously injected 125 I-albumin (plasma extravasation) and myeloperoxidase (MPO) activity (neutrophil recruitment). Histamine or C48/80 significantly evoked itching behavior paralleled by plasma extravasation and increased MPO activity. Na2S and LR significantly ameliorated histamine or C48/80-induced pruritus and inflammation, although these effects were less pronounced or absent with GYY4137. Inhibition of endogenous H2S synthesis exacerbated C48/80-induced responses, whereas the blockade of KATP channels by glibenclamide did not. Highperformance liquid chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) revealed that Na2S and LR, but not GYY4137, significantly attenuated C48/80-induced histamine release from rat peritoneal mast cell in vitro. We provide first evidences that H2S exerted protective effect against acute pruritus mediated via histaminergic pathways in murine skin, thus making of H2S donors a potential alternative/complementary therapy for treatment of acute pruritus.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Protective effects of exogenous and endogenous hydrogen sulfide in mast cell-mediated pruritus and cutaneous acute inflammation in mice

Rodrigues

Ekundi-Valentim

Florenzano

et al. 2017

Pharmacological Research

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“…The involvement of NO has been proposed in the histamine-induced relaxation in mesenteric arterial bed (Jin et al, 2006), mesenteric artery (Adeagbo and Triggle, 1993;Yousif et al, 2003) and pulmonary arteries (Hasunuma et al, 1991) of the rat and coronary arterial bed of the guinea pig (Pierpaoli et al, 2003). In parallel, both NO and prostanoids are involved in the histamine-induced relaxation of bovine retinal arteries (Benedito et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

“…Correspond to: Prof. Agnaldo B. Chies, Laboratory of Pharmacology, Faculty of Medicine of Marília, Monte Carmelo 800, Fragata 17 519-030, Marília, São Paulo, Brazil Phone: +55-14-34021726 Fax: +55-14-34134344 e-mail: agnaldochies@hotmail.com receptors in many arterial beds of different animal species such as rat thoracic aorta (Van de Voorde and Leusen, 1983) and mesenteric arterial bed (Adeagbo and Oriowo, 1998;Jin et al, 2006), guinea-pig pulmonary artery (Abacioglu et al, 1987) and gastrointestinal arterioles (Beyak and Vanner, 1995), isolated monkey and dog coronary arteries (Toda, 1986) and bovine retinal arteries (Benedito et al, 1991). Stimulation of H1 receptor also evoked endotheliumdependent relaxation in human cranial (Jansen-Olesen, 1997) and subcutaneous resistance arteries ( Van de Voorde et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

The possible involvement of hyperpolarizing mechanisms in histamine-induced relaxation of the rat portal vein

Rossignoli

Rodrigues

Tinti

et al. 2008

J. Smooth Muscle Res.

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The present study evaluated the effects of histamine 10 -2 M on longitudinal preparations of rat portal vein. It was observed that histamine 10 -2 M induced relaxation of rat portal vein preparations pre-contracted with phenylephrine 10 -4 M. On the other hand, no pharmacological effects were observed in preparations not pre-contracted. The observed histamine-induced relaxing effect was absent in preparations pre-contracted with KCl (120 mM) or in the presence of depolarizing nutritive solution. However, the histamine-induced relaxation was still present in the endothelium-removed preparations. The histamine-induced relaxation also was not prevented by astemizole ( M or L-NAME 10 -4 M plus indomethacin 10 -5 M also did not prevent the histamineinduced relaxation observed in rat portal vein. Thus, the histamine-induced relaxation observed in rat portal vein appears to involve a non-endothelial hyperpolarizing mechanism independent of H1, H2 and H3 receptors.

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“…Histamine causes both endothelium-dependent (1, 2) and -independent (1,3) vasorelaxations in various animal species (4), which are mediated by histamine H 1 , H 2 , and H 3 receptors. Additionally, histamine has been reported to produce perivascular nerve-mediated vascular responses (1).…”

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confidence: 99%

Adrenergic Stimulation–Released Histamine Taken-up in Adrenergic Nerves Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance Arteries

et al. 2012

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Abstract. The present study investigated whether histamine was taken up by perivascular adrenergic nerves and released by periarterial nerve stimulation (PNS) to induce vascular responses. In rat mesenteric vascular beds treated with capsaicin to eliminate calcitonin gene-related peptide (CGRP)ergic vasodilation and with active tone, PNS (1 -4 Hz) induced only adrenergic nervemediated vasoconstriction. Histamine treatment for 20 min induced PNS-induced vasoconstriction followed by vasodilation without affecting CGRP-induced vasodilation. Chlorpheniramine, guanethidine, combination of histamine and desipramine, and endothelium-removal abolished PNS-induced vasodilation in histamine-treated preparations. These results suggest that histamine taken up by and released from adrenergic nerves by PNS causes endothelium-dependent vasodilation in rat mesenteric arteries.

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Histamine-induced vasodilation and vasoconstriction in the mesenteric resistance artery of the rat

Cited by 36 publications

References 18 publications

Protective effects of exogenous and endogenous hydrogen sulfide in mast cell-mediated pruritus and cutaneous acute inflammation in mice

Protective effects of exogenous and endogenous hydrogen sulfide in mast cell-mediated pruritus and cutaneous acute inflammation in mice

The possible involvement of hyperpolarizing mechanisms in histamine-induced relaxation of the rat portal vein

Adrenergic Stimulation–Released Histamine Taken-up in Adrenergic Nerves Induces Endothelium-Dependent Vasodilation in Rat Mesenteric Resistance Arteries

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