Histamine in the brain: Beyond sleep and memory

Passani, Maria Beatrice; Giannoni, Patrizia; Bucherelli, Corrado; Baldi, Elisabetta; Blandina, Patrizio

doi:10.1016/j.bcp.2006.12.002

Cited by 78 publications

(60 citation statements)

References 87 publications

(107 reference statements)

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“…Given the lack of memory-enhancing effects on short-term memory in young mice, these data suggest that a significant increase in the latency to step down revealed in 7-month-old mice treated with dimebon during the first recall session was due to its non-specific inhibitory effects on locomotion. Data on the suppressive effects of dimebon on exploratory vertical activity in the novel cage are in line with the well-documented sedative effects of histamine receptor blockers (Passani et al, 2007;Van Ruitenbeek et Step down avoidance 3-m-o 0.1 mg/kg --0.5 mg/kg + -7-m-o 0.5 mg/kg + + n.a. n.a.…”

Section: Discussionsupporting

confidence: 75%

Dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory memory tasks in mice

Vignisse

Steinbusch

Bolkunov

et al. 2011

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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a b s t r a c t a r t i c l e i n f oPre-clinical and clinical studies on dimebon (dimebolin or latrepirdine) have demonstrated its use as a cognitive enhancer. Here, we show that dimebon administered to 3-month-old C57BL6N mice 15 min prior to training in both appetitive and inhibitory learning tasks via repeated (0.1 mg/kg) and acute (0.5 mg/kg) i.p. injections, respectively, increases memory scores. Acute treatment with dimebon was found to enhance inhibitory learning, as also shown in the step-down avoidance paradigm in 7-month-old mice. Bolus administration of dimebon did not affect the animals' locomotion, exploration or anxiety-like behaviour, with the exception of exploratory behaviour in older mice in the novel cage test. In a model of appetitive learning, a spatial version of the Y-maze, dimebon increased the rate of correct choices and decreased the latency of accessing a water reward after water deprivation, and increased the duration of drinking behaviour during training/testing procedures. Repeated treatment with dimebon did not alter the behaviours in other tests or water consumption. Acute treatment of water-deprived and non-water-deprived mice with dimebon also did not affect their water intake. Our data suggest that dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory tasks in mice.

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Section: Discussionsupporting

confidence: 75%

Dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory memory tasks in mice

Vignisse

Steinbusch

Bolkunov

et al. 2011

Progress in Neuro-Psychopharmacology and Biological Psychiatry

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show abstract

“…In the recent years it has gained importance as a signaling molecule in processes of sleepwake cycle, appetite control, learning, memory and emotion [1,2], moreover, its signaling pathways seem to be involved in conditions such as depression, schizophrenia, Alzheimer's disease and epilepsy [2].…”

Section: Introductionmentioning

confidence: 99%

Histamine (re)uptake by astrocytes: an experimental and computational study

2009

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“…H3 receptors, originally described as presynaptic autoreceptors on brain histaminergic neurons that control histamine synthesis and release, were subsequently recharacterised as heteroreceptors on non-histaminergic neurons in the central and peripheral nervous systems. They have also been found in immune cells and in smooth muscle (Coruzzi et al, 2001;Passani et al, 2007) where they have been associated with immediate and allergic hypersensitivity. When histamine binds with these receptors, they affect the contraction of smooth muscle cells, the dilation of blood vessels and, therefore, an efflux of blood serum is established into the surrounding tissues (including the mucous membranes) and initiating the inflammatory process (Rangachari, 1992).…”

Section: Physiological Role Of Biogenic Aminesmentioning

confidence: 99%