Histamine in human breast cancer

Abstract

The concentration of histamine in breast cancer was sufficient to inhibit lymphocyte function and could be locally immunosuppressive.

The role of histamine in human mammary carcinogenesis: H3 and H4 receptors as potential therapeutic targets for breast cancer treatment.

“…In accordance with previous reports demonstrating higher HDC activity in breast cancer in comparison to normal tissue, [13][14][15] HDC protein expression was significantly augmented in breast carcinomas. Nevertheless, the increase in histamine content observed in carcinomas was not significant.…”

“…[9][10][11][12] High histamine biosynthesis and content has been reported in different human neoplasias including breast cancer, as well as in experimental tumors induced in rodents. 5,[13][14][15] We have previously reported that H1R and H2R are present in different normal and malignant cell lines and benign lesions and tumors derived from human mammary gland. [16][17][18][19][20] Furthermore, in experimental mammary carcinomas, histamine becomes an autocrine growth factor capable of regulating cell proliferation via H1R and H2R.…”

The presence of stromal mast cells identifies a subset of invasive breast cancers with a favorable prognosis

“…15 An immunosuppressive role for mast cells in breast cancer, mediated via histamine, has also been postulated. 16 A negative correlation between the number of mast cells present in regional lymph nodes and the presence of breast cancer metastases has been noted, 17 which further suggests a potential inhibitory role for mast cells on tumor growth. This concept has been supported by recent studies in a rat model of breast carcinoma.…”

Does Famotidine Enhance Tumor Infiltrating Lymphocytes in Breast Cancer?

“…H igh levels of histamine and histidine decarboxylase have been demonstrated in tumor interstitium (13 -15). In addition, high levels of histamine have also been identi ed in human skin, rectal and breast cancer (16)(17)(18)(19) (18). In a recent study evaluating the concentration of histamine in breast cancer, it was concluded that the Table 2 Signi cant lymphocyte in ltration in the two groups concentration of histamine in breast cancer was suf cient to inhibit the lymphocytic function and could be immunosuppressive locally (16).…”

“…In a recent study evaluating the concentration of histamine in breast cancer, it was concluded that the Table 2 Signi cant lymphocyte in ltration in the two groups concentration of histamine in breast cancer was suf cient to inhibit the lymphocytic function and could be immunosuppressive locally (16). H istamine induces immunosuppression by inhibiting lymphocyte migration (16,20) and reducing the lytic ability of cytotoxic T lymphocytes (9). H istamine also inhibits the natural killer cell activity (21,22).…”