Histamine in atrial fibrillation (AF) — Is there any connection? Results from an unselected population

Layritz, Christian; Hagel, Alexander; Graf, Vanessa; Reiser, Christian O. A.; Klinghammer, Lutz; Ropers, Dieter; Achenbach, Stephan; Raithel, Martin

doi:10.1016/j.ijcard.2013.12.185

Cited by 10 publications

(11 citation statements)

References 14 publications

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“…It is involved in local immune responses and an immunological mediator in inflammatory conditions, which physiologically regulates some cardiovascular functions and acts as a neurotransmitter. Augmented histamine levels seem to be linked to an arrhythmogenic potential in cellular and animal models: in guinea pigs, a stimulation of the H2-receptor in the right atrium determined an important heart rate acceleration [4].…”

Section: Role Of Histaminementioning

confidence: 99%

“…Stimulation of the H2-receptor in the right atrium and the H1-receptor in the left atrium triggers spontaneous diastolic depolarization, which may be involved in paroxysmal atrial tachycardia [26]. For example, the depolarization of purkinje-fibers induced by histamine has been reported to promote ventricular tachycardias [4]. In addition, rare cases of cardiac arrests and AF have been described in patients with clinically established hyperhistaminemia in mastocytosis and in anaphylaxis [27].…”

Section: Role Of Histaminementioning

confidence: 99%

“…In addition, rare cases of cardiac arrests and AF have been described in patients with clinically established hyperhistaminemia in mastocytosis and in anaphylaxis [27]. Because of its broad arrhythmogenic potential, and the lack of prospective data on the role of histamine in patients with AF, a pilot study was recently performed to evaluate plasma histamine concentrations in patients with AF: there was a subpopulation of 10 patients with AF (21.2% of the enrolled subjects) that demonstrated clearly elevated levels of histamine [4]. In these patients, increased plasma histamine levels may be the result of ingestion of histamine containing food, allergic or pseudo-allergic reactions, infectious or immunologic disorders or other factors [28].…”

Section: Role Of Histaminementioning

confidence: 99%

“…However, a large number of AF occurs in absence of known structural anomalies or cardiovascular diseases and no pathological cardiac findings can be documented [3]. It is unclear whether immunological, infectious or allergic diseases may also be related to AF [4]: probably, in these patients, functional, neurohumoral and even dietary mechanisms may be responsible to induce AF. On the one hand, there is a well-known positive correlation between AF and obesity, inflammation, heavy alcohol consumption, hypertension, type 2 diabetes mellitus and dyslipidemia [5].…”

Section: Introductionmentioning

confidence: 99%

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Food-Related Atrial Fibrillation? The Potential Role of Biogenic Amines in “Nutri-Arrhythmias” Genesis

Gammone

Vicentini

Riccioni

et al. 2018

Reports

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Atrial fibrillation (AF) is the most common type of arrhythmia: a disorganized electrical atrial activity leading to irregular ventricular beats. Its most common risk factors include high blood pressure, congenital and valvular heart diseases, aging, heart failure and coronary heart diseases. Other risk factors include excessive alcohol intake, tobacco smoking, diabetes mellitus and thyrotoxicosis. However, many cases are not associated with any of these risk factors: probably, in these patients, immunological, functional and even dietary mechanisms may be responsible to induce cardiac arrhythmias. Several studies have focused on immunological and neurohumoral mechanisms; however, little information is available about the potential relationship between dietary patterns and atrial fibrillation episodes. This case report describes a potential correlation between biogenic amines in ingested food and recurrent atrial fibrillation onset in a 61-years old man in absence of a remarkable clinical history and of the most common risk factors. The nutritional team instituted a food protocol: a low calories diet and eliminating biogenic amines-rich foods. During the follow-up (16 months), there was a noticeable weight loss and no arrhythmic episodes happened again. This clinical case provides evidence for a possible new relationship between some kinds of food and heart conduction (defining the very novel field of arrhythmogenic foods and of “nutri-arrhythmias”), recognizing biogenic amines-rich foods abuse as the potential trigger and substrate for atrial fibrillation. Therefore, we suggested that clinical history in patients with new onset AF should also include questions concerning the ingestion of histamine-rich foodstuffs (or other amines-rich food) and alcohol consumption: their effects may result to be synergistic in the alteration of cardiac rhythm and may explain the recurrence of an unexplained atrial fibrillation.

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Section: Role Of Histaminementioning

confidence: 99%

Section: Role Of Histaminementioning

confidence: 99%

Section: Role Of Histaminementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Food-Related Atrial Fibrillation? The Potential Role of Biogenic Amines in “Nutri-Arrhythmias” Genesis

Gammone

Vicentini

Riccioni

et al. 2018

Reports

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“…El corazón representa tanto una fuente, como un blanco de los mediadores inmunológicos liberados durante reacciones alérgicas graves (41). Los mastocitos, que se encuentran presentes de manera abundante en este órgano, al activarse liberan mediadores que influyen en la función ventricular, el ritmo cardiaco y el tono de las arterias coronarias, ocasionando manifestaciones que incluyen hipotensión y shock, arritmias cardiacas, disfunción ventricular e infarto, este último conocido como síndrome de Kounis, el cual se define como la concurrencia de síndrome coronario agudo y anafilaxia (44)(45)(46)(47).…”

Section: Características Clínicasunclassified

Anafilaxia: estado del arte

Londoño

Raigosa

Vásquez

et al. 2018

iatreia

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La anafilaxia se define como una reacción de hipersensibilidad, sistémica, de instauración rápida y potencialmente fatal, con manifestaciones clínicas y severidad variable, que resulta de la liberación súbita de mediadores de mastocitos y basófilos. El diagnóstico de esta entidad es fundamentalmente clínico, basándose en los patrones de manifestación y la exposición a un posible detonante. Actualmente varios estudios indican deficiencias en la identificación y manejo de esta enfermedad, lo que genera un riesgo elevado de mortalidad. En esta revisión presentamos puntos prácticos del manejo e identificamos las principales consideraciones a tener en cuenta en el primer nivel de atención.

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Human histamine H2 receptors can initiate cardiac arrhythmias in a transgenic mouse

Gergs

Weisgut

Griethe

et al. 2021

Naunyn-Schmiedeberg's Arch Pharmacol

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Histamine is known to lead to arrhythmias in the human heart. A mouse model to mimic these effects has hitherto not been available but might be useful to study the mechanism(s) of H2-histamine receptor-induced arrhythmias and may support the search for new antiarrhythmic drugs. In order to establish such a model in mice, we studied here the incidence of cardiac arrhythmias under basal and under stimulated conditions in atrial and ventricular preparations from mice that overexpressed the human H2-histamine receptors in a cardiac-specific way (H2-TG) in comparison with their wild-type (WT) littermate controls. We had shown before that histamine exerted concentration and time-dependent positive inotropic and positive chronotropic effects only in cardiac preparations from H2-TG and not from WT. We noted under basal conditions (no drug addition) that right atrial preparations from H2-TG exhibited more spontaneous arrhythmias than right atrial preparations from WT. These arrhythmias in H2-TG could be blocked by the H2-histamine receptor antagonist cimetidine. In a similar fashion, histamine and dimaprit (an agonist at H2 and not H1-histamine receptors) more often induced arrhythmias in right atrial preparations from H2-TG than from WT. To understand better the signal transduction mechanism(s) involved in these arrhythmias, we studied partially depolarized left atrial preparations. In these preparations, a positive inotropic effect of histamine was still present in the additional presence of 44 mM potassium ions (used to block sodium channels) in H2-TG but not WT and this positive inotropic effect could be blocked by cimetidine and this is consistent with the involvement of calcium ion channels in the contractile and thus might mediate also the arrhythmogenic effects of histamine in H2-TG. However, compounds reported to release histamine from cells and thereby leading to arrhythmias in humans, namely morphine, ketamine, and fentanyl, failed to induce a more pronounced positive inotropic effect in atrial preparations from H2-TG compared to WT, arguing against an involvement of histamine release in their proarrhythmic side effects in patients. Measuring left ventricular contractility in isolated retrogradely perfused hearts (Langendorff mode), we detected under basal conditions (no drug application) more spontaneous arrhythmias in hearts from H2-TG than from WT. In summary, we noted that overexpression of human H2-histamine receptors in a novel transgenic animal model can lead to arrhythmias. We suggest that this model might be useful to understand the mechanism(s) of histamine-induced cardiac arrhythmias in humans better in a molecular way and may be of value to screen novel antiarrhythmic drugs.

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Histamine in atrial fibrillation (AF) — Is there any connection? Results from an unselected population

Cited by 10 publications

References 14 publications

Food-Related Atrial Fibrillation? The Potential Role of Biogenic Amines in “Nutri-Arrhythmias” Genesis

Food-Related Atrial Fibrillation? The Potential Role of Biogenic Amines in “Nutri-Arrhythmias” Genesis

Anafilaxia: estado del arte

Human histamine H2 receptors can initiate cardiac arrhythmias in a transgenic mouse

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