Histamine H4 receptors on mammary epithelial cells of the human breast with different types of carcinoma

Maślińska, D.; Laure‐Kamionowska, Milena; Maslinski, K. T.; Deregowski, K; Szewczyk, Grzegorz; Maśliński, S

doi:10.1007/s00011-005-0051-z

Cited by 13 publications

(9 citation statements)

References 6 publications

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“…[61][62][63][64][65] H4R has also been shown to play a role in nociception, autoimmune disorders, and colon and breast cancer, as well as in allergy. [66][67][68][69] Animal models using selective H4R antagonists have supported the importance of this receptor in the modulation of inflammatory responses associated with asthma, arthritis, colitis and pruritis. 70,71 HR SIGNALING H1R to H4R are GPCRs, which are a large receptor family (>800 different receptors have been described), and GPCRs have been found in all eukaryotes, including yeasts.…”

Section: H4rmentioning

confidence: 98%

Regulation of the immune response and inflammation by histamine and histamine receptors

O’Mahony¹,

Akdiş²,

Akdiş³

2011

Journal of Allergy and Clinical Immunology

253

195

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Section: H4rmentioning

confidence: 98%

Regulation of the immune response and inflammation by histamine and histamine receptors

O’Mahony¹,

Akdiş²,

Akdiş³

2011

Journal of Allergy and Clinical Immunology

253

195

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“…It seems to be involved in immune regulatory functions including chemotaxis and cytokine secretion [63][64][65][66][67]. It is assumed that H4R plays an important role in nociceptive responses, autoimmune disorders, allergic conditions, colon cancer and breast cancer [68][69][70].…”

Section: Histamine Receptormentioning

confidence: 99%

Histamine, histamine receptors and their role in immune pathology

Jutel

Akdiş²,

Akdiş³

2009

Clin Experimental Allergy

281

219

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The important roles of histamine in body physiology and various pathologic events have been well established, whereas new and exciting findings are still being uncovered. Histamine is not only the major mediator of the acute inflammatory and immediate hypersensitivity responses, but has also been demonstrated to affect chronic inflammation and regulate several essential events in the immune response. The diverse effects of histamine on immune regulation are due to the differential expression and regulation of four histamine receptors (HR) and their distinct intracellular signals. Differences in the affinities of these receptors are highly decisive on the biological effects of histamine and agents that target HRs. In particular, the discovery of reciprocal regulation of T cell activity by H1 and H2 receptor activation indicating histamine-cytokine cross-talk, as well as the characterization of the fourth histamine receptor (HR4) and its expression on numerous immune and inflammatory cells have prompted a re-evaluation of the actions of histamine. This accounts for a new potential for HR antagonists and agonists in targeting various immunopathologic conditions.

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“…In the gastrointestinal tract, H 4 Rs are expressed in paracrine cells where they are involved in the regulation of gastric acid secretion, gastric mucosal defense, intestinal motility and secretion, visceral sensitivity, inflammation, immunity, and carcinogenesis (Coruzzi et al 2012). H 4 Rs have also been linked to rheumatoid arthritis (Ikawa et al 2005) and colon and breast cancer (Masini et al 2005;Maslinska et al 2006).…”

Section: H 4 Receptorsmentioning

confidence: 99%

Histamine in brain development

Molina‐Hernández

Díaz

Arias‐Montaño

2012

Journal of Neurochemistry

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J. Neurochem. (2012) 122, 872–882. Abstract The function of histamine in the adult central nervous system has been extensively studied, but data on its actions upon the developing nervous system are still scarce. Herein, we review the available information regarding the possible role for histamine in brain development. Some relevant findings are the existence of a transient histaminergic neuronal system during brain development, which includes serotonergic neurons in the midbrain and the rhombencephalon that coexpress histamine; the high levels of histamine found in several areas of the embryo nervous system at the neurogenic stage; the presence of histaminergic fibers and the expression of histamine receptors in various areas of the developing brain; and the neurogenic and proliferative effects on neural stem cells following histamine H1‐ and H2‐receptor activation, respectively. Altogether, the reviewed information supports a significant role for histamine in brain development and the need for further research in this field.

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Histamine H4 receptors on mammary epithelial cells of the human breast with different types of carcinoma

Cited by 13 publications

References 6 publications

Regulation of the immune response and inflammation by histamine and histamine receptors

Regulation of the immune response and inflammation by histamine and histamine receptors

Histamine, histamine receptors and their role in immune pathology

Histamine in brain development

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